Multiple adverse childhood experiences and asthma onset in adulthood: Role of adulthood risk factors as mediators

Lietzén, Raija; Suominen, Sakari; Sillanmäki, Lauri; Virtanen, Pekka; Virtanen, Marianna; Vahtera, Jussi

doi:10.1016/j.jpsychores.2021.110388

Cited by 16 publications

(5 citation statements)

References 42 publications

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“…For our asthma/COPD mediational model, we demonstrated mediation through depression symptoms, which does not align with other studies. Lietzén et al (2021) tested several mediators and found that both BMI and smoking partially mediated the relationship between ACEs and asthma. The proportion of the total effect of ACEs found that smoking and obesity accounted for 15% and 3%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Adverse childhood experiences and adult disease: Examining mediating pathways in the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study.

Kobayashi,

Isasi,

Suglia

et al. 2024

Health Psychology

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Objectives: Adverse childhood experiences (ACEs) have been linked to adulthood chronic diseases, but there is little research examining the mechanisms underlying this association. We tested pathways from ACEs to adult disease mediated via risk factors of depression, smoking, and body mass index. Method: Prospective data from adults 18 to 74 years old from the Hispanic Community Health Study/ Study of Latinos and Sociocultural Ancillary Study were used. Retrospectively reported ACEs and hypothesized mediators were measured at Visit 1 (2008)(2009)(2010)(2011). Outcomes of disease prevalence were assessed at Visit 2, approximately 6 years later. The analytic sample includes 5,230 Hispanic/Latino participants with ACE data. Statistical mediation was examined using structural equation modeling on cardiometabolic and pulmonary disease prevalence and reported probit regression coefficients with 95% confidence intervals (CIs). Results: We found a significant association between ACEs and the prevalence of asthma/chronic obstructive pulmonary disorder (standardized β = .07, 95% CI [0.02, 0.12]). In the mediational model, the direct association was nonsignificant (β = .02, 95% CI [−0.04, 0.07]) but was mediated by depressive symptoms (β = .03, 95% CI [0.02, 0.04]). There were no associations between ACEs and the prevalence of diabetes and self-reported coronary heart disease or cerebrovascular disease. However, a small indirect effect was identified via depressive symptoms and coronary heart disease (β = .02, 95% CI [0.01, 0.03]). Conclusion: In this diverse Hispanic/Latino sample, depressive symptoms were found to be a pathway linking ACEs to self-reported cardiopulmonary diseases, although the effects were of small magnitude. Future work should replicate pathways, confirm the magnitude of effects, and examine cultural moderators that may dampen expected associations.Anna Catriona Whittaker served as action editor.

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Section: Discussionmentioning

confidence: 99%

Adverse childhood experiences and adult disease: Examining mediating pathways in the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study.

Kobayashi,

Isasi,

Suglia

et al. 2024

Health Psychology

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“…Statistically significant differences by gender, age, and level of education have been found in the number of ACEs experienced. Women, younger adults, and those with lower educational attainment were more likely to report a higher number of ACEs (Lietzén et al, 2021). In addition, employment status, race/ethnicity and income (Racine et al, 2021) have also been shown to be correlated with ACEs, where employed (Brown et al, 2017; Hardcastle et al, 2018), racial/ethnic minority individuals (Brown et al, 2017; Chu & Chu, 2021), and those with lower income tend (Brown et al, 2017) to report more ACEs.…”

Section: Methodsmentioning

confidence: 99%

Adverse Childhood Experiences and Subjective Cognitive Decline in the US

et al. 2021

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Objective The aim of this study was to determine the association between adverse childhood experiences (ACEs) and subjective cognitive decline (SCD) among a representative sample of the adult US population. Methods Data were obtained from the 2019 Behavioral Risk Factor Surveillance System ( N = 82,688, ≥45 years). Adverse childhood experiences included sexual, physical/psychological and environmental ACEs, and a score. Multivariable logistic regression was used to determine the association between ACEs and SCD, and SCD-related outcomes. Results Sexual (adjusted OR (aOR: 2.83; 95% CI: 2.42–3.31)), physical/psychological (aOR: 2.05; 95% CI: 1.83–2.29), and environmental (aOR: 1.94; 95% CI: 1.74–2.16) ACEs were associated with SCD in the past year. There was also a dose-response relationship between ACE score and SCD. Conclusion ACEs were associated with SCD. Interventions to maximize cognitive health in aging and prevent future cognitive impairment should consider the potential role of ACEs among affected populations.

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“…Compared with those who did not experience ACEs, individuals who experienced ACEs have been reported to be at greater risk for developing asthma at some point in their lives. [7][8][9][10] Additionally, certain characteristics of ACEs, such as the number and the type of ACEs, may also significantly impact an individual's risk for developing asthma. Those who report three or more ACEs have an increased risk of developing asthma.…”

Section: Aces and Asthma Riskmentioning

confidence: 99%

Asthma and adverse childhood experiences

Perugini,

Parsh

2024

Nursing

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EdD, RN, CNS, reply-ACEs are potentially traumatic events, such as physical, emotional, or sexual abuse, neglect, caregiver mental illness or addiction, and other forms of household dysfunction, that occur during childhood. 1 They are associated with chronic health problems and poor health outcomes later in life. 1 ACEs have been linked to several diseases that may be exacerbated by toxic stress that causes prolonged sympathetic nervous system activation. 2,3 In the US, one in every six adults reported experiencing four or more ACEs. 1 Additionally, of the 10 leading causes of death, 5 are associated with ACEs, including heart disease, cancer, respiratory diseases, diabetes, and suicide. 1 Asthma is a chronic respiratory disorder characterized by chronic airway inflammation and airway hyperresponsiveness, which can cause wheezing, shortness of breath, and in severe cases, death. 4 Asthma affects 8.3% of Americans and ranks as the most common chronic disease in the pediatric population. 5 Asthma accounts for 1.3 million ED visits and 3,500 deaths each year, and an estimated annual fiscal cost of $56 billion. 5 Although the exact cause of asthma is unknown, possible causative factors include interactions between genetic factors and environmental allergens. 6 Asthma usually starts during childhood before the age of 5 and is more common in children than adults. 5,6 Recent studies are evaluating the link between chronic stress and respiratory disorders such as asthma. [8][9][10] Jaden Perugini is a student at Sacramento State School of Nursing, where Bridget Parsh is a professor. Dr. Parsh is also a member of the Nursing2024 Editorial Board.

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Multiple adverse childhood experiences and asthma onset in adulthood: Role of adulthood risk factors as mediators

Cited by 16 publications

References 42 publications

Adverse childhood experiences and adult disease: Examining mediating pathways in the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study.

Adverse childhood experiences and adult disease: Examining mediating pathways in the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study.

Adverse Childhood Experiences and Subjective Cognitive Decline in the US

Asthma and adverse childhood experiences

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