Multiplanar MR temperature‐sensitive imaging of cerebral thermal treatment using interstitial ultrasound applicators in a canine model

Kangasniemi, Marko; Diederich, Chris J.; Price, Roger E.; Stafford, R. Jason; Schomer, Donald F.; Olsson, Lars; Tyréus, Per Daniel; Nau, William H.; Hazle, John D.

doi:10.1002/jmri.10191

Cited by 50 publications

(56 citation statements)

References 29 publications

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“…The assumed number of measurements is larger than in a typical clinical application with catheterized thermocouples, but is substantially smaller than achievable with MR thermal imaging. The sampling rate of 1 s is selected to match currently achievable sampling rate with the MRI thermometry [36], [37].…”

Section: Simulation Resultsmentioning

confidence: 99%

Minimum-Time Thermal Dose Control of Thermal Therapies

Arora

Skliar

Roemer

2005

IEEE Trans. Biomed. Eng.

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The problem of controlling noninvasive thermal therapies is formulated as the problem of directly controlling thermal dose of the target. To limit the damage to the surrounding normal tissue, the constraints on the peak allowable temperatures in the selected spacial locations are imposed. The developed controller has a cascade structure with a linear, constrained, model predictive temperature controller in the secondary loop. The temperature controller manipulates the intensity of the ultrasound transducer with saturation constraints, which noninvasively heats the spatially distributed target. The main nonlinear thermal dose controller dynamically generates the reference temperature trajectories for the temperature controller. The thermal dose controller is designed to force the treatment progression at either the actuation or temperature constraints, which is required to minimize the treatment time. The developed controller is applicable to high and low-intensity treatments, such as thermal ablation and thermoradiotherapy. The developed approach is tested using computer simulations for a one-dimensional model of a tumor with constraints on the maximum allowable temperature in the normal tissue and a constrained power output of the ultrasound transducer. The simulation results demonstrate that the proposed approach is effective at delivering the desired thermal dose in a near minimum time without violating constraints on the maximum allowable temperature in healthy tissue, despite significant plant-model mismatch introduced during numerical simulation. The results of in vitro and in vivo validation are reported elsewhere.

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Section: Simulation Resultsmentioning

confidence: 99%

Minimum-Time Thermal Dose Control of Thermal Therapies

Arora

Skliar

Roemer

2005

IEEE Trans. Biomed. Eng.

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“…The damage end point used in this study has been reported or used in other published reports. 7,8,26,27 In this study, we used the DSC to quantitatively measure the spatial overlap between model-predicted damage and that evident on post-treatment images because of this technique's advantages over other methods. Receiver operating characteristic curves, another well-known validation metric, were not used because the chosen total area analyzed ͑which is arbitrary͒ would affect the curve's outcome.…”

Section: Discussionmentioning

confidence: 99%

“…After the administration of a contrast agent, the peripheral region of enhancement surrounding the nonperfused zone has been shown to be in good agreement with histologic findings as a marker for thermal coagulation. 8,26,27 One such study by Breen et al 7 showed that the tissue within the hyperintense and central regions closely corresponded to the region of dead or irreversibly damaged cells in histology. Their experiment consisted of carefully acquiring MR and tissue images in the same plane, which were later aligned for comparison and cell-viability staining techniques.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative comparison of thermal dose models in normal canine brain

et al. 2010

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Purpose: Minimally invasive thermal ablative therapies as alternatives to conventional surgical management of solid tumors and other pathologies is increasing owing to the potential benefits of performing these procedures in an outpatient setting with reduced complications and comorbidity. Magnetic resonance temperature imaging ͑MRTI͒ measurement allows existing thermal dose models to use the spatiotemporal temperature history to estimate the thermal damage to tissue. However, the various thermal dose models presented in the literature employ different parameters and thresholds, affecting the reliability of thermal dosimetry. In this study, the authors quantitatively compared three thermal dose models ͑Arrhenius rate process, CEM 43 , and threshold temperature͒ using the dice similarity coefficient ͑DSC͒. Methods: The DSC was used to compare the spatial overlap between the region of thermal damage as predicted by the models for in vivo normal canine brain during thermal therapy to the region of thermal damage as revealed by contrast-enhanced T1-weighted images acquired immediately after therapy ͑Ͻ20 min͒. The outer edge of the hyperintense rim of the ablation region was used as the surrogate marker for the limits of thermal coagulation. The DSC was also used to investigate the impact of varying the thresholds on each models' ability to predict the zone of thermal necrosis. Results: At previously reported thresholds, the authors found that all three models showed good agreement ͑defined as DSCϾ 0.7͒ with post-treatment imaging. All three models examined across the range of commonly applied thresholds consistently showed highly accurate spatial overlap, low variability, and little dependence on temperature uncertainty. DSC values corresponding to cited thresholds were not significantly different from peak DSC values. Conclusions: Thus, the authors conclude that the all three thermal dose models can be used as a reliable surrogate for postcontrast tissue damage verification imaging in rapid ablation procedures and can also be used to enhance the capability of MRTI to control thermal therapy in real time.

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“…Kangasniemi et al 48 achieved with these dual-mode arrays was reported comparable to imaging from standard trans-abdominal ultrasound imaging probes and is able to detect thermal lesioning (showed as a hyperechoic region after ultrasound as exposure).…”

Section: Mri-guidance and Monitoring Of Interstitial Ultrasound Applimentioning

confidence: 90%

Interstitial devices for minimally invasive thermal ablation by high-intensity ultrasound

Lafon

Melodelima

Salomir

et al. 2007

International Journal of Hyperthermia

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2Interstitial devices for minimally invasive thermal ablation by high intensity ultrasound AbstractInterstitial ultrasound applicators have been proposed for treating deep-seated tumors that can not be reached with extracorporeal High Intensity Focused Ultrasound. In addition, interstitial ultrasound offers several advantages compared with conventional ablation technology (radiofrequency, microwaves, cryotherapy …) in terms of penetration, speed of coagulation, ability to direct and control the thermal lesion and compatibility with image monitoring. The ultrasound source is brought as close as possible to the target in order to minimize the effects of attenuation and phase aberration along the ultrasound pathway. The present paper is a review of the interstitial applicators that were described during the last decade in the literature. It is presented in three sections. The technical aspects common to all applicators are first described. For example, most described applicators are sideview applicators which active element is water-cooled and operates at rather high frequency (above 3MHz) in order to promote heating. Then the different potential techniques for monitoring treatment administered by the interstitial route are presented and illustrated through a review of imageguided interstitial thermal ablation. Three major techniques of imaging are used for guiding interstitial treatment: MRI, ultrasound and fluoroscopy. The third section will go further in detail on diverse described medical applications.3

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Multiplanar MR temperature‐sensitive imaging of cerebral thermal treatment using interstitial ultrasound applicators in a canine model

Cited by 50 publications

References 29 publications

Minimum-Time Thermal Dose Control of Thermal Therapies

Minimum-Time Thermal Dose Control of Thermal Therapies

Quantitative comparison of thermal dose models in normal canine brain

Interstitial devices for minimally invasive thermal ablation by high-intensity ultrasound

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