Multiphase flow in microfluidics: From droplets and bubbles to the encapsulated structures

Sattari, Amirmohammad; Hanafizadeh, Pedram; Hoorfar, Mina

doi:10.1016/j.cis.2020.102208

Cited by 90 publications

(70 citation statements)

References 293 publications

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“…116 In this section, we review some of the most recent advances in microfluidic crystals and compartmentalisation, citing also some pioneering works in the field. A broader overview of the applications related to microfluidic compartmentalisation (not only crystals) can be found in the following recent reviews: encapsulation, 117 singlecell analysis, 118 multiple emulsions, 119,120 self-assembly, 121 and production of biomaterials. 122…”

Section: Microfluidic Crystals and Compartmentalisationmentioning

confidence: 99%

“…A more controlled approach for the fabrication of compartmentalised crystal structures is based on doublet emulsions, i.e., a multiple-phase dispersion in which droplets enclosing fined droplets are suspended in a continuous liquid phase 134,135 (the interested reader is referred to the recent review by Sattari et al 119 ). An interesting development has been presented by Sajjadi et al 115 who introduced a microfluidic device for the formation of double emulsions based on the co-flow droplet generation geometry.…”

Section: Crystal Formation In Dropletsmentioning

confidence: 99%

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Microfluidic formation of crystal-like structures

2021

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Section: Microfluidic Crystals and Compartmentalisationmentioning

confidence: 99%

Section: Crystal Formation In Dropletsmentioning

confidence: 99%

Microfluidic formation of crystal-like structures

2021

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“…The advantage of SAW is that a large number of pressure waves can be generated with a small voltage (5 V). Additionally, the pressure wave can manipulate any object in the channel, regardless of the object dielectric constant, conductivity, refractive index, and other characteristics (Sattari et al., 2020). This is completely different from the electric drive, which is significantly affected by the dielectric constant and conductivity (Li et al., 2015).…”

Section: Driving Modes Of Microfluidic Chipsmentioning

confidence: 99%

Computer simulation of submicron fluid flows in microfluidic chips and their applications in food analysis

Xie

Sun

2021

Comp Rev Food Sci Food Safe

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In recent years, countries around the world have maintained a zero‐tolerance attitude toward safety problems in the food industry. In order to ensure human health, a fast, sensitive, and high‐throughput analysis of food contaminants is necessary to ensure safe food products on the market. Microfluidics, as a high‐efficiency and sensitive detection technology, has many advantages in the detection of food contaminants, including foodborne pathogens, pesticides, heavy metal ions, toxic substances, and so forth, especially in conjunction with a variety of submicron fluid driving methods, making food detection and analysis more efficient and accurate. This review introduces the principle of submicron fluid driving modes and discusses the driving simulation of submicron fluid in microfluidic chips. In addition, the latest developments in the application of simulation in food analysis from 2006 to 2020 are discussed, and the computer simulation of submicron fluid flow in microfluidic chips and its application and development trend in food analysis are also highlighted. The review indicates that microfluidic technology, using numerical simulation as an auxiliary tool, combined with traditional methods has greatly improved the detection and analysis of food products. In addition, microfluidics combined with a variety of control methods embodies the ability of specific, multifunctional, and sensitive detection and analysis of food products. The development of high‐sensitivity, high‐throughput, portable, integrated microfluidic chips will enable the technology to be applied in practice.

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“…There has been a thriving interest in micro uidics due to their breadth of applications in diverse branches of science and industry, from biological applications to food science and chemistry. By operating at a miniature scale, micro uidic systems can offer advantages such as regulating and manipulating uids with tremendous precision, enabling precise control over small sample volumes, and reducing analysis time [1]. Attention to the droplet-based micro uidic systems has been expanding extensively in past decades due to their substantial applications in various areas, such as cell culture [2], chemical synthesis [3], extraction and phase transfer [4], etc.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, the inner jet stream does not touch the microchannel wall, and therefore no surface wall treatment is required for the production of microdroplets. This con guration also bene ts from high monodispersity and signi cant throughput of droplet generation compared to other conventional geometries [1]. Various combinations of the aforementioned geometries have been widely used due to take advantage of both geometry [26] and generation of double emulsions [27] such as two subsequent T-junctions [28], ow-focusing [29], and coowing [30], a combination of T-junction and co-owing [31], and a combination of T-junction and owfocusing [32].…”

Section: Introductionmentioning

confidence: 99%

Microfluidic on-chip Production of Alginate Hydrogels Using Double Co-flow Geometry

Sattari

Janfaza

Keshtiban

et al. 2021

Preprint

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Microfluidic on-chip production of microgels employing external gelation has numerous biological and pharmaceutical applications, particularly for the encapsulation of delicate cargos, however, the on-chip production of microgels in microfluidic devices can be challenging due to problems such as clogging caused by accelerated progress in precursor solution viscosity. Here, we introduce a novel microfluidic design incorporating two consecutive co-flow geometries for microfluidic droplet generation. A shielding oil phase is employed to avoid emulsification and gelation stages from occurring simultaneously, thereby preventing clogging. The results revealed that the microfluidic device could generate highly monodispersed spherical droplets (coefficient of variation < 3%) with an average diameter in the range of 60–200 μm. Additionally, it was demonstrated that the device could appropriately create a shelter of the oil phase around the inner aqueous phase regardless of the droplet formation regime and flow conditions. The ability of the proposed microfluidic device in the generation of microgels was validated by producing alginate microgels utilizing an aqueous solution of calcium chloride as the continuous phase.

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Multiphase flow in microfluidics: From droplets and bubbles to the encapsulated structures

Cited by 90 publications

References 293 publications

Microfluidic formation of crystal-like structures

Microfluidic formation of crystal-like structures

Computer simulation of submicron fluid flows in microfluidic chips and their applications in food analysis

Microfluidic on-chip Production of Alginate Hydrogels Using Double Co-flow Geometry

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