Multiphase flow in microfluidic systems – Control and applications of droplets and interfaces

Shui, Lingling; Eijkel, Jan C.T.; Berg, Albert van den

doi:10.1016/j.cis.2007.03.001

Cited by 200 publications

(156 citation statements)

References 127 publications

(270 reference statements)

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…In many cases multiphase fluids have to be transported through these devices [31,32]. In multiphasic microfluidic applications the size of the droplets can become comparable to the dimensions of the channel.…”

Section: 84mentioning

confidence: 99%

See 1 more Smart Citation

The effect of geometrical confinement on coalescence efficiency of droplet pairs in shear flow

Bruyn

Cardinaels

Moldenaers

2013

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 1The effect of geometrical confinement on coalescence efficiency of droplet pairs in shear flow AbstractDroplet coalescence is determined by the combined effect of the collision frequency and the coalescence efficiency of colliding droplets. In the present work, the effect of geometrical confinement on coalescence efficiency in shear flow is experimentally investigated by means of a counter rotating parallel plate device, equipped with a microscope. The model system consisted of Newtonian droplets in a Newtonian matrix. The ratio of droplet diameter to plate spacing ( ) is varied between 0.06 and 0.42, thus covering bulk as well as confined conditions. Droplet interactions are investigated for the complete range of offsets between the droplet centers in the velocity gradient direction. It is observed that due to confinement coalescence is possible up to higher initial offsets. On the other hand, confinement also induces a lower boundary for the initial offset, below which the droplets reverse during their interaction, thus rendering coalescence impossible.Numerical simulations in 2D show that the latter phenomenon is caused by recirculation flows at the front and rear of confined droplet pairs. The lower boundary is independent of , but increases with increasing confinement ratio and droplet size. The overall coalescence efficiency is significantly larger in confined conditions as compared to bulk conditions.

show abstract

Section: 84mentioning

confidence: 99%

“…The use of microfluidic devices is emerging in a variety of applications [28][29][30][31]. In many cases multiphase fluids have to be transported through these devices [31,32].…”

Section: 84mentioning

confidence: 99%

The effect of geometrical confinement on coalescence efficiency of droplet pairs in shear flow

Bruyn

Cardinaels

Moldenaers

2013

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

show abstract

“…[58][59][60][61][62][63][64][65] Many well-written review articles have been published on the subject of droplet flow. 9,[66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81] In this review, parallel two-phase flow 6,[82][83][84][85] is considered with respect to the roles of liquid interfaces for the sake of simplified physical descriptions.…”

Section: ·1 Two-phase Flowmentioning

confidence: 99%

Interfacial Phenomena and Fluid Control in Micro/Nanofluidics

et al. 2016

View full text Add to dashboard Cite

“…Microfluidics controls fluids at the microscale and can generate micrometer diameter droplets and bubbles with a narrow size distribution and controlled hierarchical structures ( Figure 1A) [9][10][11][12][13]. Most importantly, micro-size polymer particles including hydrogel particles can be synthesized using droplets generated by microfluidic approaches as templates [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Microfluidic-Based Synthesis of Hydrogel Particles for Cell Microencapsulation and Cell-Based Drug Delivery

2012

View full text Add to dashboard Cite

Encapsulation of cells in hydrogel particles has been demonstrated as an effective approach to deliver therapeutic agents. The properties of hydrogel particles, such as the chemical composition, size, porosity, and number of cells per particle, affect cellular functions and consequently play important roles for the cell-based drug delivery. Microfluidics has shown unparalleled advantages for the synthesis of polymer particles and been utilized to produce hydrogel particles with a well-defined size, shape and morphology. Most importantly, during the encapsulation process, microfluidics can control the number of cells per particle and the overall encapsulation efficiency. Therefore, microfluidics is becoming the powerful approach for cell microencapsulation and construction of cell-based drug delivery systems. In this article, I summarize and discuss microfluidic approaches that have been developed recently for the synthesis of hydrogel particles and encapsulation of cells. I will start by classifying different types of hydrogel material, including natural biopolymers and synthetic polymers that are used for cell encapsulation, and then focus on the current status and challenges of microfluidic-based approaches. Finally, applications of cell-containing hydrogel particles for cell-based drug delivery, particularly for cancer therapy, are discussed.

show abstract

Multiphase flow in microfluidic systems – Control and applications of droplets and interfaces

Cited by 200 publications

References 127 publications

The effect of geometrical confinement on coalescence efficiency of droplet pairs in shear flow

The effect of geometrical confinement on coalescence efficiency of droplet pairs in shear flow

Interfacial Phenomena and Fluid Control in Micro/Nanofluidics

Microfluidic-Based Synthesis of Hydrogel Particles for Cell Microencapsulation and Cell-Based Drug Delivery

Contact Info

Product

Resources

About