Multipel Sklerosis pada Anak

Rizminardo, Fredyton; Syarief, Iskandar; Lestari, Rahmi; Handayani, Tuti

doi:10.25077/jka.v7i0.927

Cited by 4 publications

(23 citation statements)

References 14 publications

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“…Kira-kira 10-20% penderita mengalaami jenis ini. 6,7,[11][12][13] Sering terjadi keadaan paraparesis spastik yang progresif lambat, diikuti sindrom hemiplegi atau serebelar. 13…”

Section: Continuing Medical Educationunclassified

“…Terjadi kemunduran terusmenerus dengan serangan-serangan sporadis. 6,7,[11][12][13] 4. SPMS (Secondary Progressive Multiple Sclerosis) Pada jenis ini, hampir 70% penderita MS mengalami kekambuhan dan perbaikan yang hilang timbul dan diikuti dengan bentuk perkembangan gejala yang mengarah pada perburukan neurologis progresif disertai kekambuhan terusmenerus.…”

Section: Rpms (Relapsing Progressive Multiple Sclerosis)unclassified

“…7,12,14 Sekitar 50% penderita RRMS mengalami jenis ini dalam 10 tahun. 6,7,[11][12][13] 5. CIS (Clinically Isolated Syndrome) Sindrom terisolasi klinis (CIS) menggambarkan onset klinis pertama sklerosis multipel potensial.…”

Section: Rpms (Relapsing Progressive Multiple Sclerosis)unclassified

“…Gambar T1 setelah pemberian gadolinium (Gd) yang menunjukkan peningkatan lesi. 6,7,13 Pencitraan T2 dan Proton Density (PD) (Gambar 6 A dan B) bisa mengidentifikasi lesi MS sebagai fokus sinyal tinggi terhadap latar belakang sinyal rendah subtansia alba. Namun, lesi periventrikuler sering tidak dapat dibedakan dari cairan CSF (Cerebrospinal Fluid) yang berdekatan.…”

Section: Continuing Medical Educationunclassified

“…Kontras bisa ditingkatkan dengan PD karena sinyal CSF lebih rendah. 6,7,13 FLAIR (Gambar 6 C) unggul untuk deteksi lesi CONTINUING MEDICAL EDUCATION kortikal atau jukstakortikal. Oleh karena itu, FLAIR umum digunakan untuk skrining MS. Kelemahannya adalah deteksi lesi di fossa posterior dan sumsum tulang belakang memiliki kualitas rendah, sedangkan PD dan T2 lebih akurat.…”

Section: Continuing Medical Educationunclassified

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Sklerosis Multipel: Diagnosis dan Tatalaksana

Suryo¹

2021

CDK

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Sklerosis multipel adalah lesi multipel sistem saraf pusat akibat rusaknya selubung mielin yang membungkus akson. Penyakit ini termasuk penyakit neurodegeneratif bersifat progresif dan relaps, sering mengenai wanita dewasa muda, memerlukan penanganan komprehensif dan sistematis. Penyebab penyakit belum diketahui pasti, diduga berkaitan dengan faktor infeksi virus atau proses autoimun atau genetik. Manifestasi klinisnya bervariasi. Kriteria diagnosis terbaru didasarkan pada Kriteria McDonald tahun 2017. Tatalaksana mencegah relaps dan progresivitas menggunakan kortikosteroid, imunosupresan, imunomodulator, plasmapheresis (pertukaran plasma), atau DMAMS (Disease-Modifying Agent for Multiple Sclerosis), atau stem cell therapy. Prognosis tergantung komplikasi, progresivitas penyakit dan pilihan terapi.Multiple sclerosis is multiple lesions of the central nervous system due to damage to the axons’ myelin sheaths. This neurodegenerative disease is progressive and relapsing, often affecting young adult women, requiring comprehensive and systematic management. It is thought to be related to viral infection factors or autoimmune or genetic processes. The clinical manifestations are not typical depending on the brain lesion and disease progression. The latest diagnosis criteria are based on the 2017 McDonald Criteria. Management are to prevent relapse and progression using corticosteroids, immunosuppressants, immunomodulators, plasmapharesis (plasma exchange), or DMAMS (Disease-Modifying Agent For Multiple Sclerosis), or stem cell therapy. Prognosis depends on the complications, disease progression and appropriate treatment options.

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“…Kira-kira 10-20% penderita mengalaami jenis ini. 6,7,[11][12][13] Sering terjadi keadaan paraparesis spastik yang progresif lambat, diikuti sindrom hemiplegi atau serebelar. 13…”

Section: Continuing Medical Educationunclassified

Section: Rpms (Relapsing Progressive Multiple Sclerosis)unclassified

Section: Continuing Medical Educationunclassified

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Sklerosis Multipel: Diagnosis dan Tatalaksana

Suryo¹

2021

CDK

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Case Report Multiple Sclerosis

Yolanda

Wang²

2022

Open Access Maced J Med Sci

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BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease in the form of chronic inflammation of the CNS. This disease is mediated by autoreactive lymphocytes that can cross the blood-brain barrier and thus enter the CNS and cause inflammation. Chronic demyelinating CNS lesions characterize multiple sclerosis, and immunity to myelin is involved. This disease predominantly attacks the brain, spinal cord, and optic nerve. The diagnosis of MS is made clinically, and there is no single definitive test for MS. The key to diagnosis is Dissemination in Space (DIS) and Dissemination in Time (DIT). Magnetic resonance imaging has become an essential part of the diagnosis of MS after clinical. CASE REPORT: Here, we report a case of a 31 year-old woman with the main complaint of weakness of four extremities accompanied by a decreased vision and impaired urination and bowel movement. The patient was diagnosed with suspected MS. CONCLUSION: The patient subsequently was treated with intravenous steroids and, on the routine follow-up found marked clinical improvement.

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Mielopati Non Kompresif: Pendekatan Diagnosis

Setiawan¹

2020

CDK

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Mielopati merupakan kondisi patologis medula spinalis yang mengakibatkan gangguan fungsi motorik, sensorik dan otonom. Mielopati dibagi dua jenis yaitu mielopati kompresif dan mielopati non kompresif. Mielopati non kompresif disebabkan oleh berbagai etiologi seperti infeksi, demielinisasi, vaskular, otoimun atau gangguan metabolik. Pada tatalaksana mielopati akut, prioritas utama adalah menentukan penyebab dengan magnetic resonance imaging (MRI). Mielopati kompresif yang merupakan kondisi gawat darurat, sebagian memerlukan penanganan bedah, sedangkan sebagian besar penatalaksanaan mielopati non kompresif dengan terapi medikamentosa.Myelopathy describes pathologic conditions of spinal cord resulting in loss of spinal motor, sensory, and autonomic function. Myelopathy can be divided into two broad categories of non compressive and compressive myelopathy. Non compressive myelopathy may result from infectious, demyelinating, vascular, autoimmune, and metabolic disorders. In acute myelopathy, the utmost priority is to exclude acute compressive cause by MR imaging. Some cases of compressive myelopathy presented as a neurological emergency are managed surgically, but vast majority of non compressive myelopathy are medically managed.

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Multipel Sklerosis pada Anak

Cited by 4 publications

References 14 publications

Sklerosis Multipel: Diagnosis dan Tatalaksana

Sklerosis Multipel: Diagnosis dan Tatalaksana

Case Report Multiple Sclerosis

Mielopati Non Kompresif: Pendekatan Diagnosis

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