Multiparametric ultrasound in the detection of prostate cancer: a systematic review

Postema, Arnoud W.; Mischi, Massimo; Rosette, Jean de la; Wijkstra, Hessel

doi:10.1007/s00345-015-1523-6

Cited by 101 publications

(82 citation statements)

References 59 publications

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“…The combination of different ultrasound modalities significantly improves diagnostic performance [16], and examination using transrectal and power Doppler ultrasound remains accessible and cheap. New modalities, such as differential tissue harmonic imaging with high-frequency probes, perform better than fundamental sonography.…”

Section: Discussionmentioning

confidence: 99%

“…Various authors reported additional value of the Doppler techniques over TRUS [9,16,18]. For Eisenberg et al [22], adding PDS to TRUS improved specificity from 47 to 74 %, although the sensitivity decreased from 58 to 47 %.…”

Section: Discussionmentioning

confidence: 99%

“…Power Doppler ultrasound can detect flow in vessels as small as 1 mm and, therefore, allows visualization of a tumor's feeding vessels. However, the true angiogenic microvessels are in the 10-50 lM range [23,24]; for larger feeding vessels, Doppler US is more sensitive to higher Gleason grade lesions [9,16,24]. Overdiagnosis affected 40 % of the screened patients [25].…”

Section: Discussionmentioning

confidence: 99%

“…Combining different ultrasound modalities and the new ultrasound techniques can potentially improve PCa detection, grading, and staging. [14][15][16][17][18]. This paper aims to assess a prospective series of 429 patients for the probability of having a low-risk lesion that could require active surveillance (AS) after prostate biopsies in patients with a normal digital rectal examination (DRE), a PSA level between 4 and 10 ng/ml, and a normal or abnormal TRUS-PDS examination.…”

Section: Introductionmentioning

confidence: 99%

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Limiting overdiagnosis of low-risk prostate cancer through an evaluation of the predictive value of transrectal and power Doppler ultrasonography

Sauvain

Papavero

et al. 2016

J Ultrasound

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Purpose Overdiagnosis induced by prostate cancer screening makes necessary a better selection of candidate patients for prostate biopsy. The objective of our study is to assess the probability of having a high-or low-risk lesion that could require active surveillance (AS) after biopsies and a normal or abnormal examination, including transrectal and power Doppler ultrasonography (TRUS-PDS). Methods Four hundred and twenty-nine consecutive patients with a PSA level \10 ng/ml and a normal digital rectal examination (DRE) had guided biopsies in a prospective study. We used D'Amico's criteria to assess the risk of a biological recurrence and Dall'Era's criteria to assess possible AS. The TRUS-PDS was considered positive if one biopsy was positive in the same sextant as the suspect image. Results One hundred and seventy-seven out of 429 (41 %) T1c cancers were diagnosed; 131 out of 177 (74 %) could be qualified as low risk, and 119 out of 177 (67 %) could require AS. The TRUS-PDS was normal in 285 of 429 patients (66 %). With a normal TRUS-PDS, the probability of not having cancer with a high or intermediate risk was 96 % (negative predictive value). With an abnormal TRUS-PDS, the probability of having a positive biopsy was 59 %, and the probability of having a significant cancer was 30 %, according to the Dall'Era criteria. When TRUS-PDS was normal, these probabilities significantly decreased to 32 and 5 %, respectively (p \ 0.01). Conclusions Patients with a PSA level \10 ng/ml, a normal DRE, and a normal TRUS-PDS have a less than 5 % risk of high-or intermediate-risk cancer.Keywords Prostate cancer Á Transrectal ultrasound Á Power Doppler sonography Á Overdiagnosis Á Low risk cancer Á High-risk cancer Sommario Scopo Lo screening per la prevenzione del cancro alla prostata può portare a un eccessivo di falsi positivi; pertanto è necessaria un'attenta selezione dei pazienti candidati alla biopsia della prostata. L'obiettivo del nostro studio è quello di valutare la probabilità di avere una lesione ad alto o basso rischio che potrebbe richiedere una sorveglianza attiva (AS) dopo biopsia, e un normale o anormale esame rettale trans and power Doppler (TRUS-PDS). Metodi In uno studio prospettico, sono state eseguite 429 biopsie in pazienti consecutivi con un livello di PSA \10 ng/ml e un DRE normale. Sono stati usati i criteri di D'Amico per valutare il rischio di una recidiva biologica, e quelli di Dall'Era per la sorveglianza attiva (AS). Se anche una sola biopsia risultava positiva, anche la TRUS-PDS di conseguenza era considerata positivo. Risultati Sono stati diagnosticati 177 tumori/429 (41 %) tumori T1c: 131/177 (74 %) Sono stati qualifications come a basso rischio e 119/177 (67 %) possono richiedere un AS.La TRUS -PDS era normale in 285 dei 429 pazienti (66 %). Con un normale esame di TRUS -PDS, la probabilità di non avere un cancro con un rischio elevato o intermedio era del 96 % (valore predittivo negativo). Con una TRUS-PDS positivo per (2016( ) 19:275-280 DOI 10.1007 neoplasia, la probabilità di av...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Limiting overdiagnosis of low-risk prostate cancer through an evaluation of the predictive value of transrectal and power Doppler ultrasonography

Sauvain

Papavero

et al. 2016

J Ultrasound

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“…In the diagnosis of prostate cancer with ultrasound (US) imaging, gray scale US, Doppler US, dynamic contrast enhanced (DCE)-US and elastography have been widely used (1). The majority of prostate cancers are harder than normal prostatic tissue, due to increased micro-vascularity and a stromal response leading to increased collagen deposition around the tumor (2).…”

Section: Introductionmentioning

confidence: 99%

Novel application of three-dimensional shear wave elastography in the detection of clinically significant prostate cancer

et al. 2018

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Abstract. The present study evaluated three-dimensional shear wave elastography (3D SWE) in the detection of clinically significant prostate cancer. Clinically significant prostate cancer was defined by a minimum of one biopsy core with a Gleason score of 3+4 or 6 with a maximum cancer core length >4 mm. Patients with serum prostate-specific antigen levels of 4.0-20.0 ng/ml who were suspected of having prostate cancer from multi-parametric magnetic resonance imaging (mpMRI) were prospectively recruited. The 3D SWE was performed pre-biopsy, after which patients underwent MRI-transrectal ultrasound image-guided targeted biopsies for cancer-suspicious lesions and 12-core systematic biopsies. The pathological biopsy results were compared with the mpMRI and 3D SWE images. A total of 12 patients who were suspected of having significant cancer on mpMRI were included. The median pre-biopsy PSA value was 5.65 ng/ml. Of the 12 patients, 10 patients were diagnosed as having prostate cancer. In the targeted biopsy lesions, there was a significant difference in Young's modulus between the cancer-detected area (median 64.1 kPa, n=20) and undetected area (median 30.8 kPa, n=8; P<0.0001). On evaluation of receiver operating characteristics, a cut-off value of the Young's modulus of 41.0 kPa was used for the detection of clinically significant cancer, with which the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of cancer detection were 58, 97, 86 and 87%, respectively. When combining this cut-off tissue elasticity value with Prostate Imaging Reporting and Data System (PI-RADS) scores, the sensitivity, specificity, positive predictive value and negative predictive value of cancer detection were improved to 70, 98, 91 and 92%, respectively. In the cancer-detected lesions, a significant correlation was identified between the tissue elasticity value of the lesions and Gleason score (r=0.898, P<0.0001). In conclusion, PI-RADS combined with measurement of Young's modulus by 3D SWE may improve the diagnosis of clinically significant prostate cancer.

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Contrast‐enhanced Ultrasound in Urology

Wildeboer

Rosette

Mischi

et al. 2018

Smith's Textbook of Endourology

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Multiparametric ultrasound in the detection of prostate cancer: a systematic review

Cited by 101 publications

References 59 publications

Limiting overdiagnosis of low-risk prostate cancer through an evaluation of the predictive value of transrectal and power Doppler ultrasonography

Limiting overdiagnosis of low-risk prostate cancer through an evaluation of the predictive value of transrectal and power Doppler ultrasonography

Novel application of three-dimensional shear wave elastography in the detection of clinically significant prostate cancer

Contrast‐enhanced Ultrasound in Urology

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