Multiparametric Mapping Magnetic Resonance Imaging of Pancreatic Disease

Wang, Lixia; Gaddam, Srinivas; Wang, Nan; Deng, Zixin; Zhou, Zhengwei; Fan, Zhaoyang; Jiang, Tao; Christodoulou, Anthony G.; Han, Fei; Lo, Simon K.; Wachsman, Ashley; Hendifar, Andrew Eugene; Pandol, Stephen J.; Li, Debiao

doi:10.3389/fphys.2020.00008

Cited by 26 publications

(32 citation statements)

References 40 publications

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“…We envisage, that distinguishing the two processes by MRF might prove challenging, but further studies with histopathological correlation will be needed. Despite the higher T 1 values at 3.0 T (1010-1041 ms) obtained in this study, these remained 300-700 ms lower than those measured in patients with pancreatic disease using MOLLI (1324 ms for CP; 1675 ms for pancreatic ductal adenocarcinoma) 35 , suggesting that MRF would still be able to distinguish normal pancreatic tissue from diseased pancreas. However, we envisage that if MRF in coronal plane was to be used, then disease pancreas would also have proportionally higher values.…”

Section: Discussioncontrasting

confidence: 76%

“…The total acquisition time was very low when compared with other reported single parameter acquisitions (non-MRF based), which include quantitative T 2 measurements of the pancreas at 1.5 T: 8 min 16 and 3 T: 2 min 50 s 9 . Similar to Wang 35 , T 1 maps with MRF were obtained in 10 s/slice, although we did Figure 3. MRF-derived maps of (a) relative proton density (rPD), (b) T 1 , and (c) T 2 of three consecutive slices (posterior to anterior) within the abdomen at 1.5 T. These images show the ability of MRF to obtain multiple slices through the abdomen with reasonable anatomical detail and low motion artefact.…”

Section: Discussionsupporting

confidence: 64%

“…The MRF-T 1 values at 1.5 T and 3.0 T were shown to be 27% (584 ms) and 15% (865–884 ms) higher than in the literature, where MOLLI was used for in vivo measurements, respectively 10 , 14 , 34 , 35 . However, MOLLI can be affected by variable heart rates, incomplete tissue recovery between inversion pulses, and adiabatic inversion inefficiencies resulting in an underestimation of T 1 by as much as 25% at 3.0 T 37 and 17% at 1.5 T 38 .…”

Section: Discussionmentioning

confidence: 56%

“…The total acquisition time was very low when compared with other reported single parameter acquisitions (non-MRF based), which include quantitative T 2 measurements of the pancreas at 1.5 T: 8 min 16 and 3 T: 2 min 50 s 9 . Similar to Wang 35 , T 1 maps with MRF were obtained in 10 s/slice, although we did not perform breath-holding and obtained images at nearly half the voxel volume. Furthermore, the repeatable 20 quantitative nature of MRF data has the potential to improve comparability between centres.…”

Section: Discussionmentioning

confidence: 92%

“…Mean and standard deviation of T 1 and T 2 values for each pancreatic region. The references are: γ 34 , ‡16 ,* 14 , † 9 , φ35 , &15 .…”

mentioning

confidence: 99%

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Magnetic resonance fingerprinting of the pancreas at 1.5 T and 3.0 T

Serrao

Kessler

Carmo

et al. 2020

Sci Rep

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Magnetic resonance imaging of the pancreas is increasingly used as an important diagnostic modality for characterisation of pancreatic lesions. Pancreatic MRI protocols are mostly qualitative due to time constraints and motion sensitivity. MR Fingerprinting is an innovative acquisition technique that provides qualitative data and quantitative parameter maps from a single free‐breathing acquisition with the potential to reduce exam times. This work investigates the feasibility of MRF parameter mapping for pancreatic imaging in the presence of free-breathing exam. Sixteen healthy participants were prospectively imaged using MRF framework. Regions-of-interest were drawn in multiple solid organs including the pancreas and T1 and T2 values determined. MRF T1 and T2 mapping was performed successfully in all participants (acquisition time:2.4–3.6 min). Mean pancreatic T1 values were 37–43% lower than those of the muscle, spleen, and kidney at both 1.5 and 3.0 T. For these organs, the mean pancreatic T2 values were nearly 40% at 1.5 T and < 12% at 3.0 T. The feasibility of MRF at 1.5 T and 3 T was demonstrated in the pancreas. By enabling fast and free-breathing quantitation, MRF has the potential to add value during the clinical characterisation and grading of pathological conditions, such as pancreatitis or cancer.

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Section: Discussioncontrasting

confidence: 76%

Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 56%

“…The total acquisition time was very low when compared with other reported single parameter acquisitions (non-MRF based), which include quantitative T 2 measurements of the pancreas at 1.5 T: 8 min 16 and 3 T: 2 min 50 s 9 . Similar to Wang 35 , T 1 maps with MRF were obtained in 10 s/slice, although we did not perform breath-holding and obtained images at nearly half the voxel volume. Furthermore, the repeatable 20 quantitative nature of MRF data has the potential to improve comparability between centres.…”

Section: Discussionmentioning

confidence: 92%

“…Mean and standard deviation of T 1 and T 2 values for each pancreatic region. The references are: γ 34 , ‡16 ,* 14 , † 9 , φ35 , &15 .…”

mentioning

confidence: 99%

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Magnetic resonance fingerprinting of the pancreas at 1.5 T and 3.0 T

Serrao

Kessler

Carmo

et al. 2020

Sci Rep

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Quantitative T2 Mapping of Acute Pancreatitis

Porões,

Vietti Violi,

Piazza

et al. 2024

Magnetic Resonance Imaging

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BackgroundQuantification of the T2 signal by means of T2 mapping in acute pancreatitis (AP) has the potential to quantify the parenchymal edema. Quantitative T2 mapping may overcome the limitations of previously reported scoring systems for reliable assessment of AP.PurposeTo evaluate MR‐derived pancreatic T2 mapping values in AP and correlate them with markers of disease severity.Study TypeProspective single‐center study.Population76 adults with AP (20–91 years, females/males: 39/37).Field Strength/SequenceFat suppressed multiecho spin‐echo prototype sequence to quantify T2 signal at 3T MRI.AssessmentThe severity of AP was assessed clinically, biologically, and by contrast‐enhanced CT (CECT) performed 48–72 hours after symptom onset. MRI was then performed ≤24 hours after CT. Two readers blinded to any clinical information independently evaluated the T2 values by placing three regions of interest inside the pancreatic head, body, and tail on the T2 mapping MR sequence. Results were compared with corresponding CECT images as the standard and clinical severity parameters, using the length of hospital stay as our primary endpoint.Statistical TestsContinuous variables were compared using the Spearman's rank correlation coefficient, analysis of variance (ANOVA) or Student's t‐test.ResultsT2 values significantly correlated with the length of hospital stay (rs(74) = 0.29), CT severity index (CTSI) (rs(73) = 0.61; CTSI 0–3: 72 ± 14 msec, CTSI 4–10: 88 ± 15), intensive care unit (ICU) admission (t(2.77) = −3.41) and presence of organ failure (t(6.72) = −3.42), whereas the CTSI and Ranson score were not significantly related with ICU admission (CTSI: P = 0.24; Ranson score: P = 0.24) and organ failure (CTSI: P = 0.11; Ranson score P = 0.11).ConclusionT2 mapping correlates with AP severity parameters and is useful for assessing the severity of AP with higher sensitivity than the usual clinical and radiological scoring systems.Level of Evidence1Technical EfficacyStage 2

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Low‐rank inversion reconstruction for through‐plane accelerated radial MR fingerprinting applied to relaxometry at 0.35 T

Mickevicius

Glide-Hurst

2022

Magnetic Resonance in Med

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To reduce scan time, methods to accelerate phase-encoded/non-Cartesian MR fingerprinting (MRF) acquisitions for variable density spiral acquisitions have recently been developed. These methods are not applicable to MRF acquisitions, wherein a single k-space spoke is acquired per frame. Therefore, we propose a low-rank inversion method to resolve MRF contrast dynamics from through-plane accelerated Cartesian/radial measurements applied to quantitative relaxation-time mapping on a 0.35T system.Methods: An algorithm was implemented to reconstruct through-plane aliased low-rank images describing the contrast dynamics occurring because of the transient-state MRF acquisition. T 1 and T 2 times from accelerated acquisitions were compared with those from unaccelerated linear reconstructions in a standardized system phantom and within in vivo brain and prostate experiments on a hybrid 0.35T MRI/linear accelerator.Results: No significant differences between T 1 and T 2 times for the accelerated reconstructions were observed compared to fully sampled acquisitions (p = 0.41 and p = 0.36, respectively). The mean absolute errors in T 1 and T 2 were 5.6% and 2.9%, respectively, between the full and accelerated acquisitions. The SDs in T 1 and T 2 decreased with the advanced accelerated reconstruction compared with the unaccelerated reconstruction (p = 0.02 and p = 0.03, respectively). The quality of the T 1 and T 2 maps generated with the proposed approach are comparable to those obtained using the unaccelerated data sets.Conclusions: Through-plane accelerated MRF with radial k-space coverage was demonstrated at a low field strength of 0.35 T. This method enabled 3D T 1 and T 2 mapping at 0.35 T with a 3-min scan.

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Multiparametric Mapping Magnetic Resonance Imaging of Pancreatic Disease

Cited by 26 publications

References 40 publications

Magnetic resonance fingerprinting of the pancreas at 1.5 T and 3.0 T

Magnetic resonance fingerprinting of the pancreas at 1.5 T and 3.0 T

Quantitative T2 Mapping of Acute Pancreatitis

Low‐rank inversion reconstruction for through‐plane accelerated radial MR fingerprinting applied to relaxometry at 0.35 T

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