Multiparametric Cardiac Magnetic Resonance Imaging for Diagnosing Cardiac Allograft Vasculopathy

Lee, Ji Won

doi:10.4250/jcvi.2022.0069

Cited by 1 publication

(2 citation statements)

References 13 publications

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“…However, functional parameters such as myocardial perfusion reserve (MPR), diastolic strain (DS) rate by CMR, and peak filling rate (PFR) carry more importance for CAV diagnosis, as most studies using CMR have focused on MPI and strain imaging [ 59 , 60 ]. Therefore, a multiparametric CMR can safely measure various parameters to detect and grade CAV by assessing the myocardial tissue and function in HTx recipients without exposing them to radiation or iodinated contrast agents [ 61 ].…”

Section: Non-invasive Modalitiesmentioning

confidence: 99%

“…In their study, a higher T2 (T2 ≥ 50.2 ms) independently predicted adverse clinical outcomes (HR: 3.01; 95% CI: 1.39 to 6.54; p = 0.005) after adjusting for LVEF, left ventricular end-systolic volume (LVESV), and late gadolinium enhancement (LGE). Lee et al found that CAV grade 2/3 was associated with higher T2 values and a lower LVEF than CAV grade 1, indicating more myocardial disease in the former group [ 61 ].…”

Section: Non-invasive Modalitiesmentioning

confidence: 99%

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Cardiac Allograft Vasculopathy: Challenges and Advances in Invasive and Non-Invasive Diagnostic Modalities

Kamel,

Scalia,

Badr

et al. 2024

JCDD

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Cardiac allograft vasculopathy (CAV) is a distinct form of coronary artery disease that represents a major cause of death beyond the first year after heart transplantation. The pathophysiology of CAV is still not completely elucidated; it involves progressive circumferential wall thickening of both the epicardial and intramyocardial coronary arteries. Coronary angiography is still considered the gold-standard test for the diagnosis of CAV, and intravascular ultrasound (IVUS) can detect early intimal thickening with improved sensitivity. However, these tests are invasive and are unable to visualize and evaluate coronary microcirculation. Increasing evidence for non-invasive surveillance techniques assessing both epicardial and microvascular components of CAV may help improve early detection. These include computed tomography coronary angiography (CTCA), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and vasodilator stress myocardial contrast echocardiography perfusion imaging. This review summarizes the current state of diagnostic modalities and their utility and prognostic value for CAV and also evaluates emerging tools that may improve the early detection of this complex disease.

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Section: Non-invasive Modalitiesmentioning

confidence: 99%

Section: Non-invasive Modalitiesmentioning

confidence: 99%