Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent and malignancy

Abstract

Multiparametric MR assessment of gliomas, based on (1)H-MRSI, PWI and DWI, discriminates infiltrating tumor from surrounding vasogenic edema or normal tissues, and high- from low-grade gliomas. This approach may provide useful information for guiding stereotactic biopsies, surgical resection and radiation treatment.

Manual and semi-automatic quantification of in vivo ¹H-MRS data for the classification of human primary brain tumors

“…This partially explains the fact that we have a pronounced overlap between the spectra of different tumor groups. Even with these limitations, using both manual and semi-automatic analyses, we found a metabolic pattern in tumors and controls that was consistent with recent studies (3,4,6,7,(23)(24)(25)(26)(27). Tumors showed a reduction in the levels of NAA and creatine and an increase in the levels of choline, compared to normal tissue.…”

Comparison of Multiple Parameters Obtained on 3T Pulsed Arterial Spin-Labeling, Diffusion Tensor Imaging, and MRS and the Ki-67 Labeling Index in Evaluating Glioma Grading

“…6 Whenever possible, the ROIs were placed in mirrored white matter regions; when this placement was not possible, the ROIs were positioned in representative normal white matter in the same transaxial plane. 14 Care was taken to ensure that the ROIs were entirely within the solid part of the lesion to avoid contamination of the region of interest from normal tissue, areas of necrosis, cysts, hemorrhage, or intratumoral mineralization. We placed the ROIs at the site of the enhanced lesions on the contrast-enhanced T1-weighted MR images.…”

“…The mean ADC and minimal ADC values have been reported to be correlated with the tumor cell attenuation and thus used to grade astrocytomas. 10,14 In addition, the ADC ratio has been reported to be useful for grading gliomas. 18 Past studies have revealed that the Cho/Cr ratio tends to increase as glioma malignancy progresses.…”

Differentiation between Oligodendroglioma Genotypes Using Dynamic Susceptibility Contrast Perfusion-Weighted Imaging and Proton MR Spectroscopy

“…Multiparametric data analysis allows us to exploit the unique strengths of the different imaging techniques. As a combination of PWI and 1 H-MR spectroscopy improves the diagnostic accuracy of gliomas, 38 we used a similar approach to obtain greater discrimination of genotypes of oligodendrogliomas and showed that it was more sensitive than any single PWI/ 1 H-MR spectroscopy parameter.…”