Multiparameter flow cytometry in plasma cell disorders: when in doubt, go with the flow

Wyngaert, Zoé Van de; Boyle, Eileen M.

doi:10.1111/bjh.17972

Cited by 1 publication

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“…Multiparametric flow cytometry is the standard method to determine measurable minimal residual disease with a sensitivity of one clonal plasma cell in 10 5 cells [ 54 ], and the ability to identify certain plasma cell phenotypes with worse outcomes, such as CD117 + plasma cell precursors or CD38 low CD81 + CD117 − cells [ 55 , 56 , 57 ]. When BM plasma cell frequency is combined with serum sFLC ratio and M protein concentration, better risk stratification and risk of progression from smoldering to MM are reported [ 11 , 12 , 16 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Free Light-Chain Ratio at Diagnosis Is Associated with Early Renal Damage in Multiple Myeloma: A Case Series Real-World Study

et al. 2022

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The serum free light-chain (FLC) ratio is a sensitive tool for the differential diagnosis of plasma cell disorders and is biomarker of multiple myeloma (MM) progression from premalignant conditions. Here, we investigate the potential role of FLC ratio at diagnosis in identifying early renal damage in MM patients and other correlations with clinical, laboratory, and molecular findings. A total of 34 MM patients who had undergone autologous stem cell transplantation were included in this retrospective case series study, and FLC quantification was performed with nephelometric assays. In our study, sFLC ratio was significantly associated with light-chain MM and β-2 microglobulin levels, likely indicating a high disease burden at diagnosis, especially in patients without heavy chain M-protein at serum electrophoresis. Moreover, the sFLC ratio was inversely correlated with glomerular filtration rate, possibly identifying early renal damage in MM patients. Our preliminary results confirm the importance of early sFLC evaluation, especially in patients with the light-chain MM type and low disease burden, to minimize the risk of late renal failure.

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Section: Discussionmentioning

confidence: 99%

Serum Free Light-Chain Ratio at Diagnosis Is Associated with Early Renal Damage in Multiple Myeloma: A Case Series Real-World Study

et al. 2022

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Multiparameter flow cytometry in plasma cell disorders: when in doubt, go with the flow

Abstract: Commentary on Clichet et al. Accurate classification of plasma cell dyscrasias is achieved by combining artificial intelligence and flow cytometry.

Cited by 1 publication

References 18 publications

Serum Free Light-Chain Ratio at Diagnosis Is Associated with Early Renal Damage in Multiple Myeloma: A Case Series Real-World Study

Serum Free Light-Chain Ratio at Diagnosis Is Associated with Early Renal Damage in Multiple Myeloma: A Case Series Real-World Study

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