Multiparameter Cardiac Magnetic Resonance to Monitor Therapeutic Effect After Chemotherapy in Light Chain Amyloidosis Patients

Xiao, Li; Huang, Sisi; Miao, Huilei; Shen, Kaini; Lin, Liwu; Wang, Jian; Cao, Jian; Liu, BS Yajing; Cao, Likun; Li, Jian; Jin, Zhengyu

doi:10.1016/j.jcmg.2021.01.034

Cited by 6 publications

(8 citation statements)

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“…The development of edema is a negative determinant, and increased T2 is associated with poor prognosis and cardiac progression. 30,76 Myocardial T2 is lower in the treated patients than the untreated ones. 76 However, the remission cohort was reported to have higher native T1 and T2 values with a similarly expanded ECV than the active cohort.…”

Section: T2 Mappingmentioning

confidence: 91%

“…Low TAPSE is associated with LV dysfunction, which highlights the biventricular interdependence in RV dysfunction progression. Moreover, RV EF is sensitive to monitoring ventricular function after chemotherapy 30 …”

Section: Cinementioning

confidence: 99%

“…Hence, T2 mapping could be considered an additional marker to distinguish between these phenotypes. The development of edema is a negative determinant, and increased T2 is associated with poor prognosis and cardiac progression 30,76 . Myocardial T2 is lower in the treated patients than the untreated ones 76 .…”

Section: Parametric Mappingmentioning

confidence: 99%

“…Moreover, RV EF is sensitive to monitoring ventricular function after chemotherapy. 30 RV dysfunction not only enables robust risk stratification but also tracks changes with therapy in patients with CA. RV functional assessment should be integrated into the comprehensive CA evaluation.…”

Section: Lgementioning

confidence: 99%

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State of the Art: Quantitative Cardiac MRI in Cardiac Amyloidosis

Guo

2022

Magnetic Resonance Imaging

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Cardiac amyloidosis (CA) is characterized by amyloid infiltration in the myocardial extracellular space, causing heart failure. Patients with CA are currently underdiagnosed. Cardiac involvement is significantly associated with the prognosis and treatment decision‐making for CA. Early identification and accurate stratification are the crucial first step in patient management. Comprehensive cardiac MRI‐based evaluation of the cardiac structure, function, and myocardial tissue characterization assesses cardiac involvement by tracing disease processes. Emerging quantitative tissue characterization techniques have introduced new measures that can identify early staged CA and monitor disease progression or response after treatment. Quantitative cardiac MRI is becoming an instrumental tool in understanding CA, which leads to changes in individualized patient care. This review aimed to discuss the quantitative cardiac MRI‐based assessment of CA using established and emerging techniques. Evidence Level 5 Technical Efficacy Stage 3

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Section: T2 Mappingmentioning

confidence: 91%

Section: Cinementioning

confidence: 99%

Section: Parametric Mappingmentioning

confidence: 99%

Section: Lgementioning

confidence: 99%

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State of the Art: Quantitative Cardiac MRI in Cardiac Amyloidosis

Guo

2022

Magnetic Resonance Imaging

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“…在影像技术层面, 团队在国内率先将全心及靶容积冠脉MRA 成像方法应用于无对比剂冠脉MRA成像, 诊断敏感性、特异性显著提高, 达到国际先进水平 [19] . 在心肌病影像诊断方面, 团队建立了淀粉样变性、肢端肥大症等系统性疾病心脏受累的前瞻性病例队列, 完善心血管影像数据库, 将心肌组织定量成像T1及T2 map-ping技术应用于系统性疾病心脏受累的早期检出、预后评价及复查随访 [20] . [27] ; 还对自身免疫性胰腺炎进行多项深入研究, 提出其诊断和预测复发的关键影像征象 [28] ;…”

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A review of the research progress of medical imaging

Lü¹,

Cheng²,

Su³

et al. 2021

Sci. Sin.-Vitae

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Serial Cardiac MRI for Quantification of the Dynamics of Anthracycline‐Induced Subclinical Myocardial Injury

Zheng

Liu

Zhao

et al. 2023

Magnetic Resonance Imaging

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BackgroundAnthracyclines are known to be associated with chemotherapy‐induced cardiotoxicity. Limited data focus on dynamic myocardial injury during the course of chemotherapy in patients with breast cancer.PurposeTo investigate the variation of tissue characterization and myocardial deformation derived by cardiac MRI during anthracycline chemotherapy.Study TypeProspective.PopulationFifty‐eight female breast cancer patients (mean age: 52.82 ± 2.61 years) were enrolled.Field Strength/SequenceA 3.0‐T, cardiac MRI including cine balanced steady‐state free precession, a modified Looker‐Locker inversion recovery (MOLLI), and a fast spin echo (FSE) T2‐weighted sequences were performed.AssessmentCardiac MRI was performed baseline and after two, four, and six cycles of chemotherapy. Assessment of global longitudinal strain (GLS), global circumstance strain (GCS), global radial strain (GRS), and strain rate (GLS‐s, GCS‐s, GRS‐s) and T1, T2 and T2* were accomplished by CVI42. The anthracycline dose and risk factors were also collected before each cardiac MRI.Statistical TestsAnalysis of variance (ANOVA) for repeated measures was used to compare the changes in LVEF cardiac function, strain and T1/T2/T2* parameters over time. Pearson correlation analyses were performed to estimate the potential associations between differences in myocardial characteristics (∆) and the chemotherapy cycle. A P value <0.05 was considered statistically significant.ResultsLVEF was not significantly different from pretreatment MRI regarding each cycle of chemotherapy (P = 0.54). Compared with baseline, patients had significantly lower GLS (−15.85% ± 0.83%, −14.50% ± 0.88%, −12.34% ± 1.01% vs. –18.82% ± 0.92%) and GLS‐s (−0.71% ± 0.07%, −0.65% ± 0.05%, −0.64% ± 0.04% vs. –0.95 ± 0.06%) and increased T2 values (57.21 ± 4.27 msec, 58.60 ± 3.93 msec, 58.10 ± 3.17 msec vs. 43.88 ± 3.28 msec) at two, four and six cycles of chemotherapy treatment. ∆GLS and ∆GLS‐s were significantly associated with the chemotherapy cycle (correlation coefficients for GLS = 0.75, GLS‐s = 0.75).Data ConclusionCardiac MRI can precisely detect the dynamic changes of anthracycline‐induced subclinical myocardial injury that is represented as a gradually decrease in GLS and GLS‐s. These parameters may provide new insight for monitoring risk and therapy in patients with breast cancer.Evidence Level2.Technical EfficacyStage 1.

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Multiparameter Cardiac Magnetic Resonance to Monitor Therapeutic Effect After Chemotherapy in Light Chain Amyloidosis Patients

Cited by 6 publications

References 4 publications

State of the Art: Quantitative Cardiac MRI in Cardiac Amyloidosis

State of the Art: Quantitative Cardiac MRI in Cardiac Amyloidosis

A review of the research progress of medical imaging

Serial Cardiac MRI for Quantification of the Dynamics of Anthracycline‐Induced Subclinical Myocardial Injury

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