Multiorientation mapping of white matter fiber microstructures in whole mouse brains using serial optical coherence tomography
Joël Lefebvre,
Alexia Pragassam,
Julien Reynaud
et al.
Abstract:Previous studies have shown that the optical coherence tomography (OCT) signal in white matter (WM) is affected by the WM fiber bundles orientation with respect to the microscope's optical axis. In this paper, we aim to exploit this contrast mechanism to generate a multi-orientation representation of WM microstructure in whole mouse brains. To achieve this, a serial blockface histology set-up has been developed combined with spectral domain OCT equipped with a long-range 10x magnification objective, achieving … Show more
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