Multiorgan distribution of human influenza A virus strains observed in a mouse model

Fislová, T; Gocník, M; Sládková, T.; Ďurmanová, Vladimı́ra; Rajčáni, J; Varečková, E; Mucha, V; Kostolanský, F

doi:10.1007/s00705-009-0318-8

Cited by 66 publications

(69 citation statements)

References 31 publications

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“…The fact that the H1N1 virus was detected in the urine of a patient tested early might indicate an early direct renal effect of the virus. Fislová et al studied the pathogenetic profiles of three strains of human influenza A virus, including the A/PR/8/34 (H1N1) strain, which is highly virulent for mice (11). The mice were infected intranasally and monitored through RT-PCR detection of the virus in respiratory and nonrespiratory tissues.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Acute Kidney Injury in Patients Infected with the 2009 Influenza A (H1N1) Virus

Abdulkader¹,

Ho²,

Santos³

et al. 2010

Clinical Journal of the American Society of Nephrology

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Section: Discussionmentioning

confidence: 99%

Characteristics of Acute Kidney Injury in Patients Infected with the 2009 Influenza A (H1N1) Virus

Abdulkader¹,

Ho²,

Santos³

et al. 2010

Clinical Journal of the American Society of Nephrology

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“…In addition, the case of influenza-related myocarditis in H2N2 influenza virus infection is also reported (4). Indeed, the animal model study can demonstrate the viral invasion into the cardiac tissue during the H3N2 influenza virus infection (5). Although there is still no data on clinical cardiology aspect on the infected cases in the present H3N2 flu outbreak, the consideration of cardiac problem is required.…”

Section: Yeni H3n2 Grip Salgınının Kardiyoloji Ile Ilgisimentioning

confidence: 98%

Cardiology concern on new H3N2 influenza outbreak

Wiwanitkit

2013

Anadolu Kardiyol Derg

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“…Adaptation of human influenza A viruses A/Miss (H3N2) and A/PR8 (H1N1) to mice has been described before (Fislová et al, 2009). Avian influenza virus A/Duck (H4N6) and rA/Vietnam (H5N1) were adapted to mice as follows: Two 6-week old BALB/c mice were infected intranasally under a light anesthesia with 40 µl of allantoic fluid containing virus.…”

Section: Virusesmentioning

confidence: 99%

“…The main goal was to examine how a previous infection of mice with human viruses influences the induction of antibodies inhibiting the replication of avian viruses. virus was attenuated by deleting the multi-basic cleavage site between HA1 and HA2 in HA molecule and was adapted to mice as described before (Fislová et al, 2009). All virus stocks used in this work (except rA/Vietnam), originated from the collection of viruses at the Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic.…”

Section: Introductionmentioning

confidence: 99%

Virus-neutralizing antibody response of mice to consecutive infection with human and avian influenza A viruses

Janulíková¹,

Stropkovská²,

Bobišová³

et al. 2015

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Summary. -In this work we simulated in a mouse model a naturally occurring situation of humans, who overcame an infection with epidemic strains of influenza A, and were subsequently exposed to avian influenza A viruses (IAV). The antibody response to avian IAV in mice previously infected with human IAV was analyzed. We used two avian IAV (A/Duck/Czechoslovakia/1956 (H4N6) and the attenuated virus rA/Viet Nam/1203-2004 (H5N1)) as well as two human IAV isolates (virus A/Mississippi/1/1985 (H3N2) of medium virulence and A/Puerto Rico/8/1934 (H1N1) of high virulence). Two repeated doses of IAV of H4 or of H5 virus elicited virus-specific neutralizing antibodies in mice. Exposure of animals previously infected with human IAV (of H3 or H1 subtype) to IAV of H4 subtype led to the production of antibodies neutralizing H4 virus in a level comparable with the level of antibodies against the human IAV used for primary infection. In contrast, no measurable levels of virus-neutralizing (VN) antibodies specific to H5 virus were detected in mice infected with H5 virus following a previous infection with human IAV. In both cases the secondary infection with avian IAV led to a significant increase of the titer of VN antibodies specific to the corresponding human virus used for primary infection. Moreover, cross-reactive HA2-specific antibodies were also induced by sequential infection. By virtue of these results we suggest that the differences in the ability of avian IAV to induce specific antibodies inhibiting virus replication after previous infection of mice with human viruses can have an impact on the interspecies transmission and spread of avian IAV in the human population.Keywords: avian influenza A viruses; sequential influenza A infection; antibody response; virus-neutralizing antibodies; HA2-specific antibodies; original antigenic sin * Corresponding author. E-mail: viruevar@savba.sk; phone: +421-2-59302427. Abbreviations: HA = hemagglutinin; IAV = influenza A virus; MAb = monoclonal antibody; OAS = original antigenic sin; VN = virus-neutralizing

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Multiorgan distribution of human influenza A virus strains observed in a mouse model

Cited by 66 publications

References 31 publications

Characteristics of Acute Kidney Injury in Patients Infected with the 2009 Influenza A (H1N1) Virus

Characteristics of Acute Kidney Injury in Patients Infected with the 2009 Influenza A (H1N1) Virus

Cardiology concern on new H3N2 influenza outbreak

Virus-neutralizing antibody response of mice to consecutive infection with human and avian influenza A viruses

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