Multiorgan disorders in connective tissue dysplasia in children. Algorithm of diagnosis. Management tactics. Draft of Russian recommendations. Part 2

Кадурина, Т И; Гнусаев, С. Ф.; Arsentev, Vadim G.

doi:10.14300/mnnc.2016.11050

Cited by 4 publications

(1 citation statement)

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“…Алгоритмы диагностики. Тактика ведения» [16]. В большинстве работ отсутствует информация о проявлениях ХрПН при разной степени выраженности несостоятельности соединительной ткани.…”

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Clinical and functional features of chronic pyelonephritis in children with connective tissue dysplasia

Иванова

Koval

2022

Pediatr (SPb)

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BACKGROUND: There is information in the literature about the effect of connective tissue dysplasia (СTD) on the course of many somatic diseases. The role of СTD in the development of chronic pyelonephritis (СhPN) is presented differently to different authors, which is why it became necessary to conduct this study. AIM: The aim of the work is to evaluate the effect of СTD on the course and manifestations of chronic secondary pyelonephritis in children. MATERIALS AND METHODS: 142 children from 6 to 17 years old with СhPN were examined. They were divided into 2 groups: the 1st group included 108 children with manifestations of СTD, including 41 people with СTD of the 3rd degree and 67 people with СTD of the 2nd degree; group 2 34 patients without СTD. The groups were comparable in gender and age. The examination was carried out according to the standards for patients with ChPN. Signs of СTD were evaluated by the method of T.I. Kadurina. RESULTS: Obstructive and mixed variants of СhPN are typical for children with СTD. In most patients, the disease manifested at 12 years of life; at school age the first signs of the disease occurred mainly in children without СTD with dysmetabolic disorders. Relapses of СhPN in children with СTD occurred 1.5 times more often during the year and 2,1 times more often during 5 years of follow-up. Patients with СTD are characterized by a wider range of pathogens, anemia, a high incidence of structural abnormalities and urodynamic disorders, a tendency to form foci of nephrosclerosis. The need for surgical treatment in the presence of СTD increases in patients with СhPN by 4.6 times, including in repeated and radical operations. In children with grade 3 СTD, all these signs are more represented. CONCLUSIONS: СTD affects the course and manifestations of СhPN in children, creating an unfavorable background. It seems promising to study the role of СTD in the occurrence of anemia in children with СhPN.

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Clinical and functional features of chronic pyelonephritis in children with connective tissue dysplasia

Иванова

Koval

2022

Pediatr (SPb)

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Complex Rehabilitation of Patients Who Survived Acute Hematogenous Osteomyelitis

Rumyantseva

Schelochenkova

Sergeechev

et al. 2019

Russian Journal of Pediatric Surgery

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Until recently, only findings of local status and laboratory diagnostics were used as objective tests which defined terms and volume of therapeutic and preventive measures for clinical examination of patients who survived acute hematogenous osteomyelitis. The prescribed complex treatment does not take into account the following indexes: patient’s co-morbidity which is characterized by the autonomic reactivity; presence of stigmas of the connective tissue dysplasia, trophic status as well as psychological characteristics of patients. During the present study, connective tissue dysplasia was revealed in 70% of patients who had acute hematogenous osteomyelitis what was confirmed by the revealed phenotypic signs and biochemical blood markers. While assessing trophic status, a disharmonious body type and insufficient physical development were seen in patients who survived septic-pyemic form of the disease. Patients who had acute hematogenous osteomyelitis, even in the absence of markers of active inflammatory process, demonstrated signs of impaired adaptation-compensatory mechanisms involving the humoral regulation and a wide range of psychological problems which reflect tension of systems and play an important role in self-development and self-maintenance of the pathological process - the so-called principle of pathoautokinesis. Patients who survived hematogenous osteomyelitis, especially in the septic form, should continue their rehabilitation, have follow-up examinations and anti-relapse treatment. In this group of patients, multidisciplinary approach is needed for developing their rehabilitation program. Terms of this program should be individualized and defined by the normalizing of objective indicators (local status and comorbid conditions).

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Markers of Hemodynamic Disorders in Children With Severe Dysplastic Deformities of the Spine and Thorax

Chelpachenko

Фисенко

Суменко

et al. 2020

RPJ

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A clinical and ultrasound examination of 126 children aged 11-16 years was carried out: 60 conditionally healthy children without structural deformations of the spine and thorax; 42 patients with dysplastic deformity of the spine and thorax, degree I-III; 24 patients with spinal and thoracal deformities of the fourth degree. For diagnosis, orthopedic and ultrasound methods were used. A significant increase in the incidence and severity of dilation of the hepatic veins in children with scoliotic deformities of the spine and chest was established. These indices were significantly elevated in children with severe deformities compared with patients with deformations of the I-III degree, these parameters being associated with the severity of the deformation of the spine and thorax. In children with severe deformities of the spine and thorax, dilation of the vena cava inferior was detected, accompanied by the dilation of the hepatic veins and associated with the severity of deformations of the spine and chest, both in the prevalence and the pronouncement of this symptom. The data obtained indicate the possibility of using dilation of the hepatic veins as one of the clinical markers for the early diagnosis of hemodynamic disorders associated with a scoliotic disease, which will allow primary health care doctors timely deciding on the need for orthopedic correction of spinal deformity to prevent the progression of scoliotic disease in children.

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Multiorgan disorders in connective tissue dysplasia in children. Algorithm of diagnosis. Management tactics. Draft of Russian recommendations. Part 2

Cited by 4 publications

References 0 publications

Clinical and functional features of chronic pyelonephritis in children with connective tissue dysplasia

Clinical and functional features of chronic pyelonephritis in children with connective tissue dysplasia

Complex Rehabilitation of Patients Who Survived Acute Hematogenous Osteomyelitis

Markers of Hemodynamic Disorders in Children With Severe Dysplastic Deformities of the Spine and Thorax

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