Multioperational Oxidase Biosensors Based on Carbosilane Dendrimers with Interacting Ferrocenes

Abstract

The bioelectrocatalytical properties and kinetic characteristics of new oxidase biosensors based on two different carbosilane dendrimers are described. The best glucose biosensor developed displayed, in an ascorbate interference free work potential interval, a strictly linear range from 0 to 4.0 mM, a detection limit of 40,6 mM and a response time less than 3 s. The lactate biosensor displayed a linear range from 0 to 0.8 mM, a detection limit of 0.73 mM and a response time less than 2 s. The apparent Michaelis-Menten constants were calculated to be 4.39 mM and 2.08 mM respectively, according to Lineweaver-Burk equation.

Synthesis and Electrochemistry of ((Diferrocenylsilyl)propyl)- and ((Triferrocenylsilyl)propyl)triethoxysilanes

“…The square wave voltammogram in this medium shows two separated oxidation waves of the same area, indicating that an equal number of electrons are transferred in both redox processes. This two-wave redox response is similar to that found in other diferrocenylsilanes. ,,,, …”

“…Extensive studies have also been performed on the respective polymeric derivatives with heteroatom bridges . As a part of a program focusing on the synthesis and applications of multiferrocenyl derivatives, our own group recently reported the synthesis of diferrocenylmethylsilane ( 1 ) and its inclusion in different dendritic and polymeric silicon-based structures.…”

Metallodendrimers Unveiled: Investigating the Formation and Features of Double-Decker Silsesquioxane-Based Silylferrocene Dendrimers

“…Dendrimers containing redox-active moieties have been the subject of extensive research due to their intriguing properties and various applications, such as electron transfer mediators, catalysts and biocatalysts, molecular sensors, and electronic devices. 4,51 Among them, ferrocene derivatives stand out for their notable characteristics, and their special ability to prepare modified electrodes, due to the change in their solubility associated with the ferrocene oxidation. 12 To study the electrochemical properties, the new dendrimers were tested by using CV in DCM solution at a low concentration of ferrocene centers (∼10 −4 M).…”

“…Ferrocene, as a representative of a classic organometallic compound, of a sandwich aromatic structure with iron as the central atom, is characterized by undoubtedly impressive redox properties and chemical and thermal stability. Ferrocene-based compounds found many applications from fuel additives, pharmaceuticals, catalysts, capacitors, and porous systems for dyes/heavy ion removal to electrochemical sensors. − However, ferrocene itself shows poor adhesion to surfaces. Therefore, its modification using diverse systems from oligo- and polysiloxanes and graphene oxide to dendrimers makes it possible to enhance this and other properties. ,− …”

Ferrocenyl Dendrimers Based on Octasilsesquioxane Cores

“…Pursuing our work dealing with the synthesis, functionalization, and study of redox properties and applications of new materials containing interacting ferrocene moieties grafted to multifunctional polymers and carbosilane dendrimers prepared by hydrosilylation of the allyl groups in the polymeric or dendritic backbones with the Si–H functionalized bis(ferrocenyl)silane dendron 1 , we report herein the synthesis of two ferrocenyl-terminated dendrimers based on octasilsesquioxane cores, which pose interesting challenges and opportunities.…”