Multiomics mapping and characterization of cellular senescence in aging human skeletal muscle uncovers a novel senotherapeutic for sarcopenia
Yang Li,
Chuhan Li,
Qin Zhou
et al.
Abstract:Cellular senescence is recognized as a hallmark of organismal aging but how it drives aging particularly in human tissues is not fully understood, partly due to the complex heterogeneous nature of senescence. Here in this study, we leverage single-nucleus multiomics to profile senescence in mononucleated cells of human skeletal muscle and provide the first senescence atlas. We demonstrate the intra-and inter-populational transcriptomic and epigenomic heterogeneity and dynamics of senescence in the cells. We al… Show more
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