Multiomics Approach to Precision Sports Nutrition: Limits, Challenges, and Possibilities

Nieman, David C.

doi:10.3389/fnut.2021.796360

Cited by 11 publications

(10 citation statements)

References 67 publications

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“…With the development of high-throughput detection and bio-omics technology, there are many efficient and accurate detection methods for athletes’ physical function and sports state evaluation, which enriches the original evaluation system ( Gomes et al, 2020 ; Nieman, 2021 ; Sellami et al, 2022 ), such as evaluation of physical performance with SNPs ( Yang et al, 2021a ). With the popularization of detection instruments and the development of detection technology, metabolomics has greatly reduced the cost and improved accuracy.…”

Section: Discussionmentioning

confidence: 99%

Blood Metabolomics Analysis Identifies Differential Serum Metabolites in Elite and Sub-elite Swimmers

Cai

Wu²,

Jing

et al. 2022

Front. Physiol.

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Objective: Metabolites in body fluids, such as lactate, glucose, and creatinine, have been measured by conventional methods to evaluate physical function and performance or athletic status. The objectives of the current study were to explore the novel metabolite biomarkers in professional swimmers with different competition levels using nuclear magnetic resonance (NMR) metabolomics, and try to establish a model to identify the athletic status or predict the competitive potential.Methods: Serum samples were collected from 103 elite and 84 sub-elite level Chinese professional swimmers, and were profiled by NMR analysis.Results: Out of the thirty-six serum metabolites profiled, ten were associated with the athletic status of swimmers (with p < 0.05). When compared with sub-elite swimmers, elite swimmers had higher levels of high-density lipoprotein (HDL), unsaturated fatty acid, lactic acid, and methanol. Elite swimmers had lower levels of isoleucine, 3-hydroxybutyric acid, acetoacetate, glutamine, glycine, and α-glucose. A model with four metabolites, including HDL, glutamine, methanol, and α-glucose, was established to predict athletic status by adjusting with different covariates. The area under the curve (AUC) of the best model was 0.904 (95% CI: 0.862-0.947), with a sensitivity and specificity of 75.5 and 90.2%, respectively.Conclusion: We have identified ten metabolite biomarkers with differentially expressed levels between elite and sub-elite swimmers, the differences could result from genetic or sports level between the two cohorts. A model with four metabolites has successfully differentiated professional swimmers with different competitive levels.

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Section: Discussionmentioning

confidence: 99%

Blood Metabolomics Analysis Identifies Differential Serum Metabolites in Elite and Sub-elite Swimmers

Cai

Wu²,

Jing

et al. 2022

Front. Physiol.

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“…[13][14][15][16][17] The blood proteome is an informative source of biomarkers representing personalized signatures of physiological phenotype, by interacting and responding to the entire body's cellular tissue disease or health state. 18 The proteome also represents an individual's genetic predisposition, continually responds to environmental factors and infectious agents as well as drug treatments, physical exercise 9,10,19,20 and nutritional intervention. 11,12,21 In addition, the proteome's unique isoforms, post-translational modifications (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5][6][7] More people are prioritizing and monitoring their personal health regime through an array of health strategies involving nutrition, physical fitness, healthy microbiome, wearable technology, and mental health wellbeing. [8][9][10][11][12] Physicians, scientists, and individuals can become proactive in their self-health management and requires appropriate assays beyond the conventional medically prescribed tests to quantitatively measure disease progression to provide actionable and personalized health insights. Both precision medicine and precision health have benefited from significant advancement of multi-omics technologies that allow millions of quantitative and qualitative tests in genomics, epigenetics, transcriptomics, proteomics, metabolomics along with the development of powerful computational bioinformatic tools and machine learning algorithms to help understand an individual's unique phenotype so that more effective interventions may be prescribed, customized and monitored for desired outcomes.…”

Section: Introductionmentioning

confidence: 99%

Assessment of a 60-biomarker health surveillance panel (HSP) on whole blood from remote sampling devices by targeted LC/MRM-MS and discovery DIA-MS analysis

Whelan

Hendricks

Dwight

et al. 2023

Preprint

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Telehealth, accessing healthcare and wellness remotely, should be a cost effective and efficient way for individuals to receive care. The convenience of having a robust remote collection device for blood tests will facilitate access to precision medicine and healthcare. Herein, we tested a 60-biomarker health surveillance panel (HSP), containing 35 FDA/LDT assays and covering at least 14 pathological states, on 8 healthy individuals ability to collect their own capillary blood from a lancet finger prick and directly compared to the traditional phlebotomist venous blood and plasma collection methods. Samples were quantitatively analyzed by a liquid chromatography-multiple reaction monitoring-mass spectrometry method targeting 114 peptides representing 60 HSP proteins and by a data-independent acquisition mass spectrometry discovery method, resulting in up to 3,811 protein identifications including 122 FDA approved biomarkers. The >90% similarity between the three biofluids indicate that remote collection devices are a viable option for personal blood proteome biosignature stratification and health analysis.

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“…Few high quality randomized controlled trials utilizing prolonged and intensive exercise bouts have been published, and these studies used disparate dosing regimens, varied research designs, and limited outcome measures that provided inconclusive findings ( 15–20 ). To better assess the potential influence of astaxanthin supplementation on exercise-induced physiological stress, this study emphasized a multi-omics approach ( 4 , 7 ). Oxylipins are bioactive oxidation products generated during stressful exercise from the metabolism of n -6 and n -3 polyunsaturated fatty acids (PUFAs) by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzyme systems.…”

Section: Introductionmentioning

confidence: 99%

Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins

et al. 2023

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ObjectivesAstaxanthin is a dark red keto-carotenoid found in aquatic animals such as salmon and shrimp, and algae (Haematococcus pluvialis). Astaxanthin has a unique molecular structure that may facilitate anti-oxidative, immunomodulatory, and anti-inflammatory effects during physiological stress. The primary objective of this study was to examine the efficacy of 4-week ingestion of astaxanthin in moderating exercise-induced inflammation and immune dysfunction using a multi-omics approach.MethodsThis study employed a randomized, double blind, placebo controlled, crossover design with two 4-week supplementation periods and a 2-week washout period. Study participants were randomized to astaxanthin and placebo trials, with supplements ingested daily for 4 weeks prior to running 2.25 h at close to 70%VO2max (including 30 min of 10% downhill running). After the washout period, participants repeated all procedures using the counterbalanced supplement. The astaxanthin capsule contained 8 mg of algae astaxanthin. Six blood samples were collected before and after supplementation (overnight fasted state), immediately post-exercise, and at 1.5, 3, and 24 h-post-exercise. Plasma aliquots were assayed using untargeted proteomics, and targeted oxylipin and cytokine panels.ResultsThe 2.25 h running bout induced significant muscle soreness, muscle damage, and inflammation. Astaxanthin supplementation had no effect on exercise-induced muscle soreness, muscle damage, and increases in six plasma cytokines and 42 oxylipins. Notably, astaxanthin supplementation countered exercise-induced decreases in 82 plasma proteins (during 24 h recovery). Biological process analysis revealed that most of these proteins were involved in immune-related functions such as defense responses, complement activation, and humoral immune system responses. Twenty plasma immunoglobulins were identified that differed significantly between the astaxanthin and placebo trials. Plasma levels of IgM decreased significantly post-exercise but recovered after the 24 h post-exercise recovery period in the astaxanthin but not the placebo trial.DiscussionThese data support that 4-week astaxanthin versus placebo supplementation did not counter exercise-induced increases in plasma cytokines and oxylipins but was linked to normalization of post-exercise plasma levels of numerous immune-related proteins including immunoglobulins within 24 h. Short-term astaxanthin supplementation (8 mg/day during a 4-week period) provided immune support for runners engaging in a vigorous 2.25 h running bout and uniquely countered decreases in plasma immunoglobulin levels.

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Multiomics Approach to Precision Sports Nutrition: Limits, Challenges, and Possibilities

Cited by 11 publications

References 67 publications

Blood Metabolomics Analysis Identifies Differential Serum Metabolites in Elite and Sub-elite Swimmers

Blood Metabolomics Analysis Identifies Differential Serum Metabolites in Elite and Sub-elite Swimmers

Assessment of a 60-biomarker health surveillance panel (HSP) on whole blood from remote sampling devices by targeted LC/MRM-MS and discovery DIA-MS analysis

Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins

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