Multiomics Analysis Reveals Aberrant Metabolism and Immunity Linked Gut Microbiota with Insomnia

Wang, Qinghua; Chen, Bin; Sheng, Dashuang; Yang, Junjie; Fu, Shujie; Wang, Jingwen; Zhao, Chuanzhi; Wang, Yihui; Gai, Xiangzhen; Wang, Jianfeng; Stirling, Kyle; Heng, Xueyuan; Man, Honghao; Zhang, Lei

doi:10.1128/spectrum.00998-22

Cited by 16 publications

(11 citation statements)

References 32 publications

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“…Insomnia is an important nervous system disease. Many studies have reported that drug intervention can improve the metabolic abnormalities of enterobacter, enterococcus, brucella, and other bacteria and correct the phenomenon of intestinal flora disorder ( Feng et al., 2023 ; Song et al., 2021 ; Wang et al., 2022 ). However, most of the previous studies involved the quantitative detection of intestinal flora, but no conclusion of causality between them was made.…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between the gut microbiota and insomnia: a two-sample Mendelian randomization study

Wang,

Gao,

Zhang

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundChanges in the gut microbiota are closely related to insomnia, but the causal relationship between them is not yet clear.ObjectiveTo clarify the relationship between the gut microbiota and insomnia and provide genetic evidence for them, we conducted a two-sample Mendelian randomization study.MethodsWe used a Mendelian randomized two-way validation method to discuss the causal relationship. First, we downloaded the data of 462,341 participants relating to insomnia, and the data of 18,340 participants relating to the gut microbiota from a genome-wide association study (GWAS). Then, we used two regression models, inverse-variance weighted (IVW) and MR-Egger regression, to evaluate the relationship between exposure factors and outcomes. Finally, we took a reverse MR analysis to assess the possibility of reverse causality.ResultsThe combined results show 19 gut microbiotas to have a causal relationship with insomnia (odds ratio (OR): 1.03; 95% confidence interval (CI): 1.01, 1.05; p=0.000 for class. Negativicutes; OR: 1.03; 95% CI: 1.01, 1.05; p=0.000 for order.Selenomonadales; OR: 1.01; 95% CI: 1.00, 1.02; p=0.003 for genus.RikenellaceaeRC9gutgroup). The results were consistent with sensitivity analyses for these bacterial traits. In reverse MR analysis, we found no statistical difference between insomnia and these gut microbiotas.ConclusionThis study can provide a new direction for the causal relationship between the gut microbiota (class.Negativicutes, order.Selenomonadales, genus.Lactococcus) and insomnia and the treatment or prevention strategies of insomnia.

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Section: Discussionmentioning

confidence: 99%

Causal relationship between the gut microbiota and insomnia: a two-sample Mendelian randomization study

Wang,

Gao,

Zhang

et al. 2024

Front. Cell. Infect. Microbiol.

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“…These conditions and consequences have a cumulative effect on insomnia. Multiple attempts have been made to build models to interpret and explain the onset and evolution of insomnia; nevertheless, these models are insufficient to represent comprehensive knowledge ( Reynolds et al., 2017 ; Gao et al., 2019 ; Cai et al, 2021 ; Jiang et al., 2022 ; Wang Q. et al., 2022 ; Zeng et al., 2023 ).…”

Section: Discussionmentioning

confidence: 99%

“…According to studies, chronic sleep deprivation is linked to higher levels of IL-1 and TNF-α in the brain, as well as higher levels of IL-6 in the blood during the day. According to research ( Wang Q. et al., 2022 ), people with acute and chronic insomnia disorders have lower abundances of several anaerobic gut flora taxa, including Lachnospira , Roseburia , and Prevotella 9 . We discovered that the genera Prevotella7 (ID:11182) and Lachnoclostridium (ID:11308) are associated with a significant incidence of insomnia.…”

Section: Discussionmentioning

confidence: 99%

The relationship between gut microbiota and insomnia: a bi-directional two-sample Mendelian randomization research

Li,

Deng,

Liu

2023

Front. Cell. Infect. Microbiol.

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IntroductionInsomnia is the second most common mental health issue, also is a social and financial burden. Insomnia affects the balance between sleep, the immune system, and the central nervous system, which may raise the risk of different systemic disorders. The gut microbiota, referred to as the “second genome,” has the ability to control host homeostasis. It has been discovered that disruption of the gut-brain axis is linked to insomnia.MethodsIn this study, we conducted MR analysis between large-scale GWAS data of GMs and insomnia to uncover potential associations.ResultsTen GM taxa were detected to have causal associations with insomnia. Among them, class Negativicutes, genus Clostridiuminnocuumgroup, genus Dorea, genus Lachnoclostridium, genus Prevotella7, and order Selenomonadalesare were linked to a higher risk of insomnia. In reverse MR analysis, we discovered a causal link between insomnia and six other GM taxa.ConclusionIt suggested that the relationship between insomnia and intestinal flora was convoluted. Our findings may offer beneficial biomarkers for disease development and prospective candidate treatment targets for insomnia.

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“…In a study of shift workers, sleep and circadian rhythm disturbances were also found to alter the diversity of gut microbiota (Reynolds et al., 2017). In addition, in patients with insomnia with different Tradition Chinese Medicine (TCM) syndromes, there are also differences in the dominant bacteria of the intestinal flora, and this difference may affect the occurrence, development, and outcome of different TCM syndromes (Wang et al., 2022d). These studies have shown that the sleep‐wake cycle and circadian rhythm disorders can affect the composition and diversity of gut microbiota.…”

Section: The Relationship Between Gut Microbiota and Circadian Rhythmsmentioning

confidence: 99%

New hints for improving sleep: Tea polyphenols mediate gut microbiota to regulate circadian disturbances

Xiang

Liu

et al. 2023

Food Frontiers

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Biological rhythm is a natural physiological phenomenon of the human body, which is regulated by the biological rhythm system, including the sleep cycle, body temperature fluctuation, endocrine level, biological metabolism, and so on. Sleep disturbance is one of the main manifestations of circadian biological rhythm disorder, which has a serious impact on people's work and quality of life. Studies have shown that gut microbiota and circadian rhythms can interact through the brain-gut pathway. Tea polyphenols can effectively modulate the composition of the intestinal microbiota. The interaction between circadian rhythm and the gut microbiota suggests that intervention with tea polyphenols is a possible way for improving sleep. Therefore, through investigating the circadian regulation mechanism of tea polyphenols mediated by gut microbiota, we can shed new light on the relationship between sleep and metabolic disturbances, as well as the beneficial effect of tea polyphenols on sleep improving.

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Multiomics Analysis Reveals Aberrant Metabolism and Immunity Linked Gut Microbiota with Insomnia

Cited by 16 publications

References 32 publications

Causal relationship between the gut microbiota and insomnia: a two-sample Mendelian randomization study

Causal relationship between the gut microbiota and insomnia: a two-sample Mendelian randomization study

The relationship between gut microbiota and insomnia: a bi-directional two-sample Mendelian randomization research

New hints for improving sleep: Tea polyphenols mediate gut microbiota to regulate circadian disturbances

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