Multiomics Analysis Confirms Effective Target Engagement for RVU120 - a First-in-Class CDK8/19 Kinase Inhibitor in AML and MR-MDS Patients and Reveals the Mechanism of Action

Rzymski, Tomasz; Sroka-Porada, Agnieszka; Kozakowska, Magdalena; Głowniak-Kwitek, Urszula; Bukowska-Straková, Karolina; Obacz, Marta; Littlewood, P. B.; Kuś, Kamil; Goller, Kristina; Kęska, Kinga; Pakulska, Urszula; Kozłowska-Tomczyk, Kamila; Madej, Monika; Mazan, Milena; Juszczyński, Przemysław; Zaucha, Jan Maciej; Zarzycka, Agnieszka; Angelosanto, Noemi; Nogai, Hendrik; Brzózka, Krzysztof

doi:10.1182/blood-2022-168906

Blood

2022

DOI: 10.1182/blood-2022-168906

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Multiomics Analysis Confirms Effective Target Engagement for RVU120 - a First-in-Class CDK8/19 Kinase Inhibitor in AML and MR-MDS Patients and Reveals the Mechanism of Action

Tomasz Rzymski¹,

Agnieszka Sroka-Porada²,

Magdalena Kozakowska³

et al.

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Multiomics Analysis Confirms Effective Target Engagement for RVU120 - a First-in-Class CDK8/19 Kinase Inhibitor in AML and MR-MDS Patients and Reveals the Mechanism of Action

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