Multiobserver Reliability of Ultrasound Assessment of Salivary Glands in Patients with Established Primary Sjögren Syndrome

Damjanov, Nemanja; Milić, Vera; Nieto‐González, Juan Carlos; Janţă, Iustina; Martínez-Estupiñán, Lina; Serrano, B.; Mata, C. F. Hernandez; Montoro, María; Stanciu, Denisa; Marinković-Erić, Jelena; López‐Longo, Francisco Javier; Carreño, Luis; Naredo, Esperanza

doi:10.3899/jrheum.151220

Cited by 22 publications

(31 citation statements)

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“…Training in the implementation of a standardised procedure is instrumental when striving for robust intrareader and inter-reader reliabilities. Studies of SGUS reliability that relied instead on static and acquisition images have produced variable results 23–26. Some studies involved the separate scoring of the items defined by Hocevar et al (echogenicity, homogeneity, hyperechoic bands, posterior border, presence or absence of calcifications and gland size) 27–29.…”

Section: Discussionmentioning

confidence: 99%

Video clip assessment of a salivary gland ultrasound scoring system in Sjögren’s syndrome using consensual definitions: an OMERACT ultrasound working group reliability exercise

Jousse‐Joulin¹,

D'Agostino²,

Nicolas³

et al. 2019

Ann Rheum Dis

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115

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ObjectiveTo develop ultrasound (US) definitions and a US novel scoring system for major salivary gland (SG) lesions in patients with primary Sjögren’s syndrome (pSS) and to test their intrareader and inter-reader reliability using US video clips.MethodsTwenty-five rheumatologists were subjected to a three-round, web-based Delphi process in order to agree on (1) definitions and scanning procedure of salivary gland ultrasonography (SGUS): parotid, submandibular and sublingual glands (PG, SMG and SLG); (2) definitions for the elementary SGUS lesions in patients with Sjögren’s syndrome; (3) scoring system for grading changes. The experts rated the statements on a 1–5 Likert scale. In the second step, SGUS video clips of patients with pSS and non-pSS sicca cases were collected containing various spectrums of disease severity followed by an intrareader and inter-reader reliability exercise. Each video clip was evaluated according to the agreed definitions.ResultsConsensual definitions were developed after three Delphi rounds. Among the three selected SGs, US assessment of PGs and SMGs was agreed on. Agreement was reached to score only greyscale lesions and to focus on anechoic/hypoechoic foci in a semiquantitative matter or, if not possible on a qualitatively (present/absent) evaluation of fatty or fibrous lesions. Intrareader reliability for detecting and scoring these lesions was excellent (Cohen’s kappa 0.81) and inter-reader reliability was good (Light’s kappa 0.66).ConclusionNew definitions for developing a novel semiquantitative US score in patients with pSS were developed and tested on video clips. Inter-reader and intrareader reliabilities were good and excellent, respectively.

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Section: Discussionmentioning

confidence: 99%

Video clip assessment of a salivary gland ultrasound scoring system in Sjögren’s syndrome using consensual definitions: an OMERACT ultrasound working group reliability exercise

Jousse‐Joulin¹,

D'Agostino²,

Nicolas³

et al. 2019

Ann Rheum Dis

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115

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“…Recently, the use of Doppler assessment has been thoroughly investigated, and the OMERACT ultrasound working group proposed a semiquantitative scoring systems to evaluate vascularization by color Doppler in pSS patients. 103 , 104 …”

Section: Monitoring Disease Activity With Sgusmentioning

confidence: 99%

Salivary Gland Ultrasound in Primary Sjögren’s Syndrome: Current and Future Perspectives

Lorenzon¹,

Spina²,

Franco³

et al. 2022

OARRR

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Salivary gland ultrasound (SGUS) is the imaging modality of choice for the assessment of parotid and submandibular gland parenchyma. Being highly effective, non-invasive and easy to perform, SGUS has become increasingly popular among specialists in assessing salivary gland (SG) abnormalities, including those commonly found in primary Sjögren’s syndrome (pSS). SGUS may be useful in the assessment of pSS and its complications, the most serious being the development of non-Hodgkin’s lymphoma (NHL). SGUS may also be useful in the characterization and differential diagnosis of diffuse and focal abnormalities commonly associated with pSS, and may act as a guide for core-needle biopsy (CNB), an established, safe, and feasible technique, which provides enough viable tissue for the diagnosis and assessment of lymphoproliferative diseases of the SG. The combination of SGUS with other tools, such as sonoelastography and artificial intelligence (AI), could further improve the usefulness of SGUS in the management of pSS. In this perspective, we summarize current and future applications of SGUS in pSS.

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“…1 , Bowman S.J. 2 , Radfar L. 3 , Omdal R. 4 , Wahren-Herlenius M. 5 , Warner B. 6 , Witte T. 7 , Jonsson R. 8 , Rischmueller M. 9 , Gaffney P. 1 , James J.A.…”

Section: Oral Communication 46 Transcriptome-wide Association Study O...mentioning

confidence: 99%

“…The population was exclusively composed of females with a median age of 54 years [47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62]. Forty-five (51.1%) participants were classified as having SjD according to 2016 ACR/EULAR criteria (median score 8 [5][6][7][8][9], among whom 28 (62%) had anti-SSA antibodies. The 43 participants used as controls had a median 2016 ACR/EULAR score of 1 [1][2].…”

Section: Objectivesmentioning

confidence: 99%

15th International Symposium on Sjögren's Syndrome

Vita

2022

Clinical and Experimental Rheumatology

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Introduction. Primary Sjogren's syndrome (pSS) is an autoimmune disease characterized by the production of pathogenic autoreactive antibodies. Despite the T cell involvement, in the physiopathology of this disease, is welldocumented, less information is available to describe the role of B cells. The etiology of this pathology is poorly understood. Nevertheless, some elements are pointed out including infections, epigenetic mechanisms, etc. Among them, glycosylation, as a physiological process, was also described as playing a key role in the development of various pathological disorders such as cancers. In autoimmunity, abnormal glycosylation of T cell markers takes place in SLE as well as on autoantibodies in pSS suggesting that dysregulation could occur in B cells. Material and methods. The aim of this project was to study, by cytometry, B cell subset glycosylation in the context of primary Sjögren's syndrome, to identify any potential alteration, and to extend the glycoprofile for serum proteins including immunoglobulins using ELISA assay. Results. We were able to demonstrate, specific glycoprofiles on B cell subsets such as N and O-glycosylation during B cell differentiation were altered in pSS. As an example of specific glycosylation, B cell hyposialylation was observed but no impairment in fucosylation was noticed. Interestingly, similar observations were obtained with the sera and immunoglobulins of these patients. Conclusions. This clearly points out that any perturbation of natural glycosylation processes in cells especially in B lymphocytes leads to the development of pathogenic autoantibodies. The correlation between the intensity of Clinical and Experimental Rheumatology 2022 15th International Symposium on Sjögren's Syndrome these alterations and the severity of autoimmune diseases could establish glycosylation as a biomarker of choice to identify the development of the pathology in patients, the physiopathology as well as the development of adapted therapeutics for them.

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Multiobserver Reliability of Ultrasound Assessment of Salivary Glands in Patients with Established Primary Sjögren Syndrome

Abstract: US may be a reliable technique in the multiobserver scoring of GS parenchymal inhomogeneity of major SG in patients with established pSS. CD scoring of SG needs further standardization to be used in multicenter studies.

Cited by 22 publications

References 20 publications

Video clip assessment of a salivary gland ultrasound scoring system in Sjögren’s syndrome using consensual definitions: an OMERACT ultrasound working group reliability exercise

Video clip assessment of a salivary gland ultrasound scoring system in Sjögren’s syndrome using consensual definitions: an OMERACT ultrasound working group reliability exercise

Salivary Gland Ultrasound in Primary Sjögren’s Syndrome: Current and Future Perspectives

15th International Symposium on Sjögren's Syndrome

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