Multinuclear MRI at Ultrahigh Fields

Niesporek, Sebastian C.; Nagel, Armin M.; Platt, Tanja

doi:10.1097/rmr.0000000000000201

Cited by 25 publications

(15 citation statements)

References 189 publications

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“… The relative sensitivity of the X-nuclei compared with conventional proton sensitivity is given as well as the relative sensitivity strength (see Equation 1), where the in vivo concentration was additionally accounted for. Table modified from Niesporek et al 137 …”

Section: X-nuclei Magnetic Resonance Spectroscopy and Magnetic Resonance Imagingmentioning

confidence: 99%

7 Tesla and Beyond

2021

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Ultrahigh magnetic fields offer significantly higher signal-to-noise ratio, and several magnetic resonance applications additionally benefit from a higher contrast-to-noise ratio, with static magnetic field strengths of B 0 ≥ 7 T currently being referred to as ultrahigh fields (UHFs). The advantages of UHF can be used to resolve structures more precisely or to visualize physiological/pathophysiological effects that would be difficult or even impossible to detect at lower field strengths. However, with these advantages also come challenges, such as inhomogeneities applying standard radiofrequency excitation techniques, higher energy deposition in the human body, and enhanced B 0 field inhomogeneities. The advantages but also the challenges of UHF as well as promising advanced methodological developments and clinical applications that particularly benefit from UHF are discussed in this review article.

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Section: X-nuclei Magnetic Resonance Spectroscopy and Magnetic Resonance Imagingmentioning

confidence: 99%

7 Tesla and Beyond

2021

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“…Higher magnetic fields result in stronger nuclear polarization [3] and, subsequently, in an increase in induced currents in the coils that translates into a quadratic increase in detected signal. An increase in signal not only allows for faster or better resolved scans, but also ushers imaging and spectroscopic measurements of low-sensitivity nuclei to clinical scanners [36].…”

Section: Mri Physics and Applicationsmentioning

confidence: 99%

Medical Physics and Imaging–A Timely Perspective

et al. 2021

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“…3 T) enables MR imaging of non-proton nuclei (e.g., 23 Na, 35 Cl, 39 K, and 17 O) in clinically feasible measurement time and acceptable spatial resolution. 32,33 Among all non-proton nuclei, sodium ( 23 Na) exhibits the best properties for in vivo applications. However, the in vivo signal-to-noise ratio (SNR) of 23 Na MRI is still four orders of magnitude lower compared with the SNR of 1 H MRI.…”

Section: Non-proton Mrimentioning

confidence: 99%

“…Physical properties and expected relative in vivo SNR of selected non-proton nuclei33,56 Derived from measured water content (71%) of brain white matter. 57 c Measured23 Na concentration of healthy calf muscle tissue36 and healthy articular cartilage58 (highest23 Na content among all tissues).…”

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Quantitative Imaging in Muscle Diseases with Focus on Non-proton MRI and Other Advanced MRI Techniques

Weber

Nagel

Kan

et al. 2020

Semin Musculoskelet Radiol

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The role of neuromuscular imaging in the diagnosis of inherited and acquired muscle diseases has gained clinical relevance. In particular, magnetic resonance imaging (MRI), especially whole-body applications, is increasingly being used for the diagnosis and monitoring of disease progression. In addition, they are considered as a powerful outcome measure in clinical trials. Because many muscle diseases have a distinct muscle involvement pattern, whole-body imaging can be of diagnostic value by identifying this pattern and thus narrowing the differential diagnosis and supporting the clinical diagnosis. In addition, more advanced MRI applications including non-proton MRI, diffusion tensor imaging, perfusion MRI, T2 mapping, and magnetic resonance spectroscopy provide deeper insights into muscle pathophysiology beyond the mere detection of fatty degeneration and/or muscle edema. In this review article, we present and discuss recent data on these quantitative MRI techniques in muscle diseases, with a particular focus on non-proton imaging techniques.

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Multinuclear MRI at Ultrahigh Fields

Cited by 25 publications

References 189 publications

7 Tesla and Beyond

7 Tesla and Beyond

Medical Physics and Imaging–A Timely Perspective

Quantitative Imaging in Muscle Diseases with Focus on Non-proton MRI and Other Advanced MRI Techniques

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