Multinuclear magnetic resonance analysis of 2-(trifluoromethyl)-2-oxazoline

Abstract

(1)H, (19)F, (13)C, (15)N, and (17)O NMR chemical shifts and (1)H-(1)H, (1)H-(19)F, (1)H-(13)C, (19)F-(13)C, and (19)F-(15)N coupling constants are reported for 2-(trifluoromethyl)-2-oxazoline.

Decarboxylative Isomerization of N-Acyl-2-oxazolidinones to 2-Oxazolines

“…Previous one-pot transformations of this type are outlined in Scheme . In the presence of an equal weight of CaO, N -benzoyloxazolidinone 1a was converted to 2a in 65% yield by heating with a Bunsen burner in the absence of solvent 5a…”

“…This method appears to have a limited substrate scope; for example, N -acetyloxazolidinone 1b under these conditions gave product 2b having purity of only 25%. Another high-temperature method, applied only to the trifluoroacetyl derivative 1c , gave 2c in 76% yield 5b. A palladium-catalyzed transformation of 5-vinyl-substituted oxazolidinones 3 to oxazolines 4 has been reported .…”