2019
DOI: 10.1038/s42005-019-0252-3
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Multinuclear absolute magnetic resonance thermometry

Abstract: Non-invasive measurement of absolute temperature is important for proper characterization of various pathologies and for evaluation of thermal dose during interventional procedures. The proton magnetic resonance (MR) frequency shift method can be used to map relative temperature changes in tissues; however, spatiotemporal variations in the main magnetic field and the lack of an internal frequency reference at each location challenge the determination of absolute temperature. Here, we introduce a novel multinuc… Show more

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Cited by 11 publications
(11 citation statements)
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“…PRF temperature measurements are also susceptible to error from magnetic field drift and have low sensitivity in fatty tissue . Such limitations have led to the development of heteronuclear approaches including using 23 Na, 129 Xe, and 19 F …”
mentioning
confidence: 99%
“…PRF temperature measurements are also susceptible to error from magnetic field drift and have low sensitivity in fatty tissue . Such limitations have led to the development of heteronuclear approaches including using 23 Na, 129 Xe, and 19 F …”
mentioning
confidence: 99%
“…The multinuclear absolute magnetic resonance thermometry offers a remedy here, but requires the appropriate equipment. [22] The measurement of heteronuclei opens up a research field in which there is so far only little data. With the aim of future pharmaceutical and/or diagnostic in vivo application and the fact that the proportion of fluorinated drugs has increased enormously in the last decades, the focus of this publication is on the study of fluorinated molecules.…”
Section: Introductionmentioning
confidence: 99%
“…Nuclear magnetic resonance (NMR) spectroscopy has been an excellent source of dynamic and structural information for a number of nuclear species, including 23 Na that has a nuclear spin 3/2 with close to 100% natural abundance, and produces the second strongest NMR signal after protons in biological tissues [13]. Concurrent measurements of both the 1 H and 23 Na nuclei can provide a method for absolute thermometry in magnetic resonance imaging [14]. The NMR sensitivity of sodium is 9.2% of that of proton, while the typical concentration can be three, or more, orders of magnitude lower than the proton concentration.…”
Section: Introductionmentioning
confidence: 99%