Multinozzle Multichannel Temperature Deposition System for Construction of a Blood Vessel

Liu, Huanbao; Zhou, Huixing; Lan, Haiming; Liu, Fu; Wang, Xuhan

doi:10.1177/2472630317712221

Cited by 13 publications

(12 citation statements)

References 17 publications

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“…After meeting these constrains, the materials that can be printed are unlimited, as well as the applications that these materials can develop. DIW is an especially promising technique for cardiovascular bioprinting, since, in cooperation with an adapted rotating bed, continuous tubular medical devices can be created without the need of printing supports [62,69]. The ability to print on a rotating mandrel is due to the implicit viscoelastic property and the shear thinning characteristic of the material, as well as high viscosity when low shear stress is applied.…”

Section: Discussionmentioning

confidence: 99%

“…The nozzle precisely controlled these parameters, so it showed good performance in printing thermosensitive materials. Additionally, this novel extrusion system offers a coaxial nozzle that allows the encapsulation of cells with a biomaterial to prevent the cells from being damaged due to the applied pressure [62]. A precise characterization of the printing parameters allows an accurate control of the material properties, such as pore size, which is relevant for cell growth in designed vascular grafts.…”

Section: Stentmentioning

confidence: 99%

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Continuous Based Direct Ink Write for Tubular Cardiovascular Medical Devices

2020

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Bioresorbable cardiovascular applications are increasing in demand as fixed medical devices cause episodes of late restenosis. The autologous treatment is, so far, the gold standard for vascular grafts due to the similarities to the replaced tissue. Thus, the possibility of customizing each application to its end user is ideal for treating pathologies within a dynamic system that receives constant stimuli, such as the cardiovascular system. Direct Ink Writing (DIW) is increasingly utilized for biomedical purposes because it can create composite bioinks by combining polymers and materials from other domains to create DIW-printable materials that provide characteristics of interest, such as anticoagulation, mechanical resistance, or radiopacity. In addition, bioinks can be tailored to encounter the optimal rheological properties for the DIW purpose. This review delves into a novel emerging field of cardiovascular medical applications, where this technology is applied in the tubular 3D printing approach. Cardiovascular stents and vascular grafts manufactured with this new technology are reviewed. The advantages and limitations of blending inks with cells, composite materials, or drugs are highlighted. Furthermore, the printing parameters and the different possibilities of designing these medical applications have been explored.

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Section: Discussionmentioning

confidence: 99%

Section: Stentmentioning

confidence: 99%

Continuous Based Direct Ink Write for Tubular Cardiovascular Medical Devices

2020

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“…Similar to nozzle described in Figure 7a, an alternative nozzle was designed by Liu et al. [ 34 ] that features a pressure control system and a temperature control system (see Figure 7c). The pressure control system allows the control of the material distribution at different speeds by adjusting the pressure in each cavity.…”

Section: For Diw and Ehd Jettingmentioning

confidence: 99%

“…Reproduced with permission. [ 34 ] Copyright 2017, Society for Laboratory Automation and Screening; d) schematic of a 3D printed hollow hydrogel fiber and the scaffold. i) CaCl2‐in‐alginate coaxial microfluidic; ii) reactor‐like spinneret.…”

Section: For Diw and Ehd Jettingmentioning

confidence: 99%

Advances in Coaxial Additive Manufacturing and Applications

Rafiee

Granier

Therriault

2021

Adv Materials Technologies

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Coaxial additive manufacturing (AM) is an emerging technology involving the simultaneous deposition of two or more materials with a common longitudinal axis. It has the potential to overcome the disadvantages associated with conventional single‐material AM for the production of core‐shell or multi‐core‐shell multimaterial structures. The coaxial AM techniques can be classified into extrusion and material jetting technologies. The extrusion‐based technologies rely on the co‐extrusion of multiple materials through a coaxial nozzle whereas the material jetting technologies are based on the introduction of a high voltage electric field between a coaxial nozzle and a grounded collector plate. This review is aimed to provide a comprehensive overview of multimaterial coaxial AM, including the technologies, nozzle designs, materials, and applications. The advances in coaxial AM and the benefits of this novel technology in various fields are highlighted. For instance, in biomedicine coaxial AM offers an exciting alternative to single‐material bioprinting for the fabrication of bio‐scaffolds and vascular networks as well as for tissue engineering and cell encapsulations. Coaxial AM is also a subject of growing interest in the fields of flexible sensors, e‐textiles, and printed electronics. Perspectives on the limitations, existing challenges, opportunities, and future directions for further development are also provided.

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“…Gao, Q. et al [27] have adopted the rotary printing method to fabricate vessel-like structures; it can proven that this method can improve the cell survival rate. Meanwhile, Liu, H. et al [28,29] have adopted the rotary printing method to obtain vessel-like structures and analyzed the synchronization among nozzle extrusion, nozzle speed, and rotating speed based on an extrusion-based 3D bioprinter, which could improve the modeling effect in this forming method.…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin

et al. 2017

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3D printing has emerged as one of the modern tissue engineering techniques that could potentially form scaffolds (with or without cells), which is useful in treating cardiovascular diseases. This technology has attracted extensive attention due to its possibility of curing disease in tissue engineering and organ regeneration. In this paper, we have developed a novel rotary forming device, prepared an alginate–gelatin solution for the fabrication of vessel-like structures, and further proposed a theoretical model to analyze the parameters of motion synchronization. Using this rotary forming device, we firstly establish a theoretical model to analyze the thickness under the different nozzle extrusion speeds, nozzle speeds, and servo motor speeds. Secondly, the experiments with alginate–gelatin solution are carried out to construct the vessel-like structures under all sorts of conditions. The experiment results show that the thickness cannot be adequately predicted by the theoretical model and the thickness can be controlled by changing the parameters. Finally, the optimized parameters of thickness have been adjusted to estimate the real thickness in 3D printing.

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Multinozzle Multichannel Temperature Deposition System for Construction of a Blood Vessel

Cited by 13 publications

References 17 publications

Continuous Based Direct Ink Write for Tubular Cardiovascular Medical Devices

Continuous Based Direct Ink Write for Tubular Cardiovascular Medical Devices

Advances in Coaxial Additive Manufacturing and Applications

3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin

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