Multinodular vacuolating and neuronal tumor of the cerebrum

Abstract

A 31-year-old woman presented with chronic headache. MRI revealed an atypical right parietal lesion involving the deep cortical ribbon and adjacent superficial subcortical white matter (figures 1 and 2).There was no enhancement after gadolinium injection. Diffusion-weighted imaging, susceptibilityweighted imaging, and dynamic-susceptibility contrast showed no abnormality. Close follow-up was

Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia?

“…Since submission of this study, further cases and series have been reported, attesting to the indolent nature of MNVT .…”

Multinodular and vacuolating neuronal tumor incidentally discovered in a young man: Conventional and advanced MRI features

“…It presents as a cluster of nodules, normally numerous and of small size, located juxtacortically on the inner surface of an otherwise normal-appearing cortex and most frequently on the parietal or temporal lobe. Gadolinium enhancement, restricted diffusion, diffuse infiltration, mass effect, or edema is not normally observed [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] .…”

“…MNVTs are rare entities that have been recently recognized, by WHO, as distinctive neuronal lesions, although they were first reported by Huse et al, in 10 patients, in 2013 [1] . Since then, 51 additional cases have been reported worldwide [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , including a case series of 33 patients by Nunes et al [9] . MVNT is frequently associated with seizures or seizure equivalents and occur mainly in adults older than 35 years.…”

“…Multinodular and vacuolating neuronal tumor (MVNT) has been included in the most recent (2016) World Health Organization Classification of Tumors of the Central Nervous System as a unique cytoarchitectural pattern of gangliocytoma, although it remains unclear whether it is a true neoplastic process or a dysplastic hamartomatous/malformative lesion [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] . Magnetic resonance imaging (MRI) findings are rather characteristic showing multiple, tiny, discrete or coalescent, sharply marginated, round or ovoid, nonenhancing nodules, located within the deep cortical ribbon and the superficial white matter, without remarkable mass effect [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] . We present a case of a patient with a MVNT tumor discovered incidentally after head injury and discuss its morphologic, diffusion, hemodynamic, and metabolic properties.…”

Multinodular and vacuolating neuronal tumour of the cerebrum: a rare neuroimaging incidentaloma or a potentially treatable cause of focal epilepsy?

“…MVNTs are of particular interest to the clinician/epileptologist, not only because of the frequent association with epileptic seizures, but also as an operatively treatable cause of epilepsy. A total of 96 cases (including the current case) have been described in the literature to date (Ratilal et al, 2007;Huse et al, 2013;Bodi et al, 2014;Fukushima et al, 2015;Nagaishi et al, 2015;Yamaguchi et al, 2016;Alsufayan et al, 2017;Badat et al, 2017;Cathcart et al, 2017;Gökç e, 2017;Monté et al, 2017;Nunes et al, 2017;Gonzalez-Quarante et al, 2018;Kapucu et al, 2018;Lobo and Srinivasan, 2018;Pekmezci et al, 2018;Thom et al, 2018) (supplementary table 1), of which 37 were histopathologically verified (HV) (38.54%). A slight female predominance was noticed in both non-HV and HV cases (M:F=2:3 and M:F=9:11, respectively).…”