Multinational experience with hypersensitivity drug reactions in Latin America

Járes, Edgardo; Sánchez‐Borges, Mario; Cardona-Villa, Ricardo; Ensina, Luis Felipe; Arias-Cruz, Alfredo; Gómez, Maximiliano; Barayazarra, Susana; Bernstein, Jonathan A.; Serrano, Carlos; Cuello, Mabel Noemi; Morfín-Maciel, Blanca María; Falco, Alicia De; Chérrez-Ojeda, Iván

doi:10.1016/j.anai.2014.06.019

Cited by 43 publications

(36 citation statements)

References 39 publications

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“…20 The focus of this analysis was to specifically assess patients experiencing DIA. 21 Similar to previous studies, we found a predominance of DIA reactions in adult and elderly female patients and not in children and/or adolescent patients.…”

Section: Discussionmentioning

confidence: 99%

“…Detailed methodology has been previously described. 20 The study was conducted from December 2011 to July 2014. DIA was defined as a moderate or severe reaction that occurred less than 24 hours after an implicated drug administration associated with urticaria and/or angioedema (U/A), and if there were at least one of the following symptoms: respiratory (R) (cough, dysphonia, dyspnea, wheezing, rhinorrhea, sneezing, nasal obstruction), gastrointestinal (GI) (nausea/emesis, diarrhea, gastrointestinal cramps), and/or cardiovascular (CV) (tachycardia, hypotension, collapse, arrhythmia).…”

Section: Methodsmentioning

confidence: 99%

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Drug-Induced Anaphylaxis in Latin American Countries

Járes

Baena-Cagnani

Sánchez‐Borges

et al. 2015

The Journal of Allergy and Clinical Immunology: In Practice

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Drug-Induced Anaphylaxis in Latin American Countries

Járes

Baena-Cagnani

Sánchez‐Borges

et al. 2015

The Journal of Allergy and Clinical Immunology: In Practice

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“…Formerly, NSAIDs have been reported to be the second most common cause of drug hypersensitivity reactions after beta-lactam antibiotics, but according to some recent studies they have risen to the most common cause (1)(2)(3). Also, NSAIDs were reported as the third leading reason for allergy consultations after rhinitis and asthma (4).…”

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confidence: 95%

Evaluation of hypersensitivity reactions to nonsteroidal anti-inflammatory drugs according to the latest classification

Demir

Olgaç

Ünal

et al. 2015

Allergy

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“…In recent years, a number of studies have supported this finding [2][3][4][5]. In contrast to reactions to ß-lactams (BLs), which are immunologically mediated [6], DHRs to NSAIDs may be induced by both specific immunological mechanisms (allergic or selective reactions [SRs]) and mechanisms not based on immunological recognition (cross-hypersensitivity reactions [CRs]) [7].…”

Section: Introductionmentioning

confidence: 99%

Immediate Reactions to More Than 1 NSAID Must Not Be Considered Cross-Hypersensitivity Unless Tolerance to ASA Is Verified

Pérez-Alzate

Cornejo-García

Pérez‐Sánchez

et al. 2017

J Investig Allergol Clin Immunol

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Background: Individuals who develop drug hypersensitivity reactions (DHRs) to chemically unrelated nonsteroidal anti-inflammatory drugs (NSAIDs) are considered cross-hypersensitive. The hallmark for this classification is that the patient presents a reaction after intake of or challenge with acetylsalicylic acid (ASA). Whether patients react to 2 or more NSAIDs while tolerating ASA remains to be studied (selective reactions, SRs). Objective: To identify patients with SRs to 2 or more NSAIDs including strong COX-1 inhibitors. Methods: Patients who attended the Allergy Service of Hospital Infanta Leonor, Madrid, Spain with DHRs to NSAIDs between January 2011 and December 2014 were evaluated. Those with 2 or more immediate reactions occurring in less than 1 hour after intake were included. After confirming tolerance to ASA, the selectivity of the response to 2 or more NSAIDs was demonstrated by in vivo and/or in vitro testing or by controlled administration. Results: From a total of 203 patients with immediate DHRs to NSAIDs, 16 (7.9%) met the inclusion criteria. The patients presented a total of 68 anaphylactic or cutaneous reactions (mean [SD], 4.2 [2.1]). Most reactions were to ibuprofen and other arylpropionic acid derivatives and to metamizole. Two different NSAIDs were involved in 11 patients and 3 in 5 patients. Conclusions: Patients with NSAID-induced anaphylaxis or urticaria/angioedema should not be considered cross-hypersensitive unless tolerance to ASA is verified.

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Multinational experience with hypersensitivity drug reactions in Latin America

Cited by 43 publications

References 39 publications

Drug-Induced Anaphylaxis in Latin American Countries

Drug-Induced Anaphylaxis in Latin American Countries

Evaluation of hypersensitivity reactions to nonsteroidal anti-inflammatory drugs according to the latest classification

Immediate Reactions to More Than 1 NSAID Must Not Be Considered Cross-Hypersensitivity Unless Tolerance to ASA Is Verified

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