Multimorbidity and mortality in older adults: A systematic review and meta-analysis

Abstract

Multimorbidity was associated with an increase in risk of death. Multimorbidity measurement standardization is needed to produce more comparable estimates. Adjusted analysis which includes potential confounders might contribute to better understanding of causal relationships between multimorbidity and mortality.

Survival in relation to multimorbidity patterns in older adults in primary care in Barcelona, Spain (2010–2014): a longitudinal study based on electronic health records

“…A recent meta-analysis showed a positive relationship between number of conditions and risk of death 9. These results contrast with our findings and with those of several other recent studies that reported a null or protective effect for number of conditions on mortality 20 21.…”

“…A meta-analysis detected a positive association between the number of chronic conditions and risk of death 9. Studies that have evaluated multimorbidity patterns based on combinations of common conditions or factor analysis have found that health outcomes vary according to the patterns analysed 10.…”

Increased Risk of Multimorbidity in Patients With Sarcoidosis: A Population-Based Cohort Study 1976 to 2013

“…Multimorbidity has important clinical implications for patient well-being and survivorship, and is associated with increased mortality 18 . It also has a substantial impact on healthcare utilization and health economics.…”

Clinical assessment and management of multimorbidity: NICE guideline

“…2 In older people this is associated with higher rates of physical health conditions, polypharmacy, adverse drug events, high treatment burden, and greater use of health services. In younger people and people from less affluent areas, multimorbidity is often due to a combination of physical and mental health conditions.…”