Multimorbidity and COVID-19 in Canada: How the Pandemic Has Highlighted a Key and Yet Underappreciated Risk Factor

Downer, Matthew B.; Sinha, Samir K.

doi:10.5770/cgj.25.611

Cited by 1 publication

(1 citation statement)

References 13 publications

(22 reference statements)

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“…Although multimorbidity has been shown to increase the probability of complications, hospitalizations, and deaths from COVID-19, it is still necessary to understand the mechanisms of the relationship between morbidities and multimorbidity in long COVID, since morbidities and multimorbidity should be included in the strategic plan for decision-making in the management of patients with long COVID [13].…”

Section: Introductionmentioning

confidence: 99%

MULTIMORBIDITY, MORBIDITIES, AND LONG COVID – findings of the Sulcovid longitudinal study

Ventura,

Vieira,

Rocha

et al. 2024

Preprint

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Background The aim of this study was to evaluate the association between long COVID, morbidities, and multimorbidity in adults and older adults six to nine months after infection with the SARS-CoV-2 virus in Southern Brazil. Methods Baseline data were obtained from the longitudinal study, Sulcovid, conducted on individuals diagnosed with COVID-19 through RT-PCR testing from December 2020 to March 2021, who were symptomatic and living in a city in southern Brazil. Long COVID was assessed based on the affirmative response to at least one of the 18 symptoms investigated and categorized as musculoskeletal, neurological, respiratory, sensory, or digestive. Morbidities were assessed based on the presence of at least one of nine self-reported diseases. Data were analyzed using the Stata 15.0 statistical package. Crude and adjusted analyses were performed using Poisson regression to assess the relationships between morbidity, multimorbidity, and long COVID. Results In total, 2,919 people were interviewed. The most prevalent morbidities were anxiety (26.3%), hypertension (25.3%), and depression (19.4%). In addition, 17.8% reported two previous morbidities and 22.6% had three or more comorbidities. Individuals with depression (PR = 1.17 95% CI 1.05–1.30), anxiety (PR = 1.33 95% CI 1.21–1.47), two or more morbidities (PR = 1.22 95% CI 1.07–1.39), and three or more morbidities (PR = 1.40; 95% CI 1.24–1.57) were more likely to have long COVID. A linear trend was observed, where individuals with two and three or more morbidities were 1.22 (95% CI 1.07–1.39) and 1.40 (95% CI 1.24–1.57) times more likely to develop long COVID than those with no or one morbidity. Conclusions The findings of this study reinforce that individuals with morbidities and multimorbidities prior to infection had greater vulnerability to long COVID.

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Section: Introductionmentioning

confidence: 99%