Multimodality Treatment Including Postoperative Radiation and Concurrent Chemotherapy with Weekly Docetaxel is Feasible and Effective in Patients with Oral and Oropharyngeal Cancer

Abstract

Concurrent radiation and chemotherapy with weekly docetaxel is a feasible postoperative treatment in a multimodality approach to oral and oropharyngeal cancer, resulting in high overall and disease-free survival. This approach warrants further evaluation in prospective randomized trials.

Outcome of patients after treatment for a squamous cell carcinoma of the oropharynx

“…These results are at the top end of the results published by others. 8,[20][21][22][23] It is difficult to compare our survival results with the literature as study groups vary with regard to number of patients, tumor stage, and treatment modality. Furthermore, treatment modalities concerning radiochemotherapy changed, especially since 2002, when the IMRT technique for radiotherapy started to be used.…”

6-Year Experience of Concurrent Radiochemotherapy with Vinorelbine Plus a Platinum Compound in Multimorbid or Aged Patients with Inoperable Non-Small Cell Lung Cancer

“…Concurrent RCT is now used in a variety of different tumors [9,10,14]; but how can this treatment benefit patients with comorbid conditions? Simultaneous RCT resulted in partial or complete remission in 74% of our patients.…”

Phase I Trial of Radiochemotherapy with Bendamustine in Patients with Recurrent Squamous Cell Carcinoma of the Head and Neck

“…On the other hand, randomized studies have demonstrated the superiority of radiotherapy in combination with chemotherapy over radiotherapy alone. RCT with multiagent chemotherapy, or with hyperfractionated radiotherapy, may lead to even better outcomes, although toxicity may be increased [2,3,8,11,14,15,17,18,20,22,25,32].…”