Multimodality Management of Urachal Carcinoma: The M. D. Anderson Cancer Center Experience

Siefker-Radtke, Arlene; Gee, Jason; Shen, Yu; Wen, Sijin; Daliani, Danai; Millikan, Randall E.; Pisters, Louis L.

doi:10.1097/01.ju.0000054646.49381.01

Cited by 250 publications

(330 citation statements)

References 11 publications

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“…The prognostic importance of differentiating urachal from nonurachal tumors is unclear in the published literature, as the reported 5-year survival rates are 27% to 61% for urachal [2][3][4][5][6][7] and 11% to 55% for nonurachal tumors. 2,3,[7][8][9] In 1 of the larger series reporting on both types, there was a trend toward improved survival in subjects with urachal adenocarcinoma, although it did not reach statistical significance (P ¼ .07).…”

Section: Discussionmentioning

confidence: 89%

“…Others have described the advanced presentation of urachal tumors and high risk of metastases, 4,6,19 and this presentation may be due to tumor growth that primarily occurs beneath the urothelium in the muscularis or deeper structures of the urachus. 3 This location may lead to a delay in diagnosis, allowing the tumor more time to grow and disseminate before becoming clinically apparent.…”

Section: Discussionmentioning

confidence: 99%

“…11 Other factors associated with poor survival include higher stage 3,5,6,8 and grade. 2,3,5,8 There are reasons to consider that outcomes may be different between urachal and nonurachal adenocarcinomas of the bladder.…”

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confidence: 99%

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Differences in survival among patients with urachal and nonurachal adenocarcinomas of the bladder

Wright¹,

Porter²,

Li³

et al. 2006

Cancer

168

170

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Background The National Institute for Occupational Safety and Health (NIOSH) conducted a health hazard evaluation (HHE) of a water‐damaged school in New Orleans (NO), Louisiana. Our aim in this evaluation was to document employee health effects related to exposure to the water‐damaged school, and to determine if VCS testing could serve as a biomarker of effect for occupants who experienced adverse health effects in a water‐damaged building. Methods NIOSH physicians and staff administered a work history and medical questionnaire, conducted visual contrast sensitivity (VCS) testing, and collected sticky‐tape, air, and dust samples at the school. Counting, culturing, and/or a DNA‐based technology, called mold‐specific quantitative PCR (MSQPCR), were also used to quantify the molds. A similar health and environmental evaluation was performed at a comparable school in Cincinnati, Ohio which was not water‐damaged. Results Extensive mold contamination was documented in the water‐damaged school and employees (n = 95) had higher prevalences of work‐related rashes and nasal, lower respiratory, and constitutional symptoms than those at the comparison school (n = 110). VCS values across all spatial frequencies were lower among employees at the water‐damaged school. Conclusions Employees exposed to an extensively water‐damaged environment reported adverse health effects, including rashes and nasal, lower respiratory, and constitutional symptoms. VCS values were lower in the employees at the water‐damaged school, but we do not recommend using it in evaluation of people exposed to mold. Am. J. Ind. Med. 55:844–854, 2012. This article is a U.S. Government work and is in the public domain in the USA.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Differences in survival among patients with urachal and nonurachal adenocarcinomas of the bladder

Wright¹,

Porter²,

Li³

et al. 2006

Cancer

168

170

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“…The tumor makes early local metastases, and distant metastases originate generally from the lymph nodes, bone, ovaries, pleura, pericardium, or meninges, but rarely from the lungs. [5][6][7] Pulmonary metastasis is seen in 20% of transitional-cell carcinoma of the bladder. Forty-six percent of these metastases are reported as multiple nodules, 25% as solitary nodules, 17% as infiltrates, 7% as pulmonary edema, 3% as Pancoast tumor.…”

Section: Discussionmentioning

confidence: 99%

“…The preferred approach for localized tumors is radical cystectomy and systemic chemotherapy, but surgery is controversial in patients who have complete response with chemotherapy. [5][6][7] For our patient with transitional-cell and primary signetring cell carcinoma we planned radical cystoprostatectomy, extended lymph node dissection, and adjuvant chemotherapy and radiotherapy, but his condition contraindicated those treatments.…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Metastasis of a Primary Transitional-Cell and Signet-Ring Cell Carcinoma of the Urinary Bladder

Çekmen¹,

Açiksöz²,

Serdaroğlu³

et al. 2011

Respir Care

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Endobronchial metastasis is generally a late finding of primary tumor or may be determined before the diagnosis of primary tumor. We present a rare case of primary transitional and signet-ring cell carcinoma of the urinary bladder that occurred with malignant pleural effusion and endobronchial metastasis. A 71-year-old man complained of dyspnea and hematuria. He was admitted to the intensive care unit (ICU) with a prediagnosis of acute respiratory failure. He had decreased respiratory sounds and fine rales bilaterally at the lung bases. Respiratory failure worsened, and he was placed on mechanical ventilation. Radiograph and computed tomogram revealed bilateral effusion and metastatic nodules in the lung parenchyma. Subsequent abdominal computed tomogram revealed a mass in the urinary bladder, and transurethral biopsy indicated transitional epithelial carcinoma (modified Bergvist grade IIIB, and World Health Organization/International Society of Urological Pathology higher-grade urothelial papillary carcinoma) and signet-ring cell carcinoma, with lymphovascular invasion, consistent with the pathology findings. Our treatment plan was radical cysto-prostatectomy, followed by chemotherapy and radiotherapy, but because of his very poor medical status, the operation was not performed. On the 5th ICU day he died from severe respiratory failure, despite intensive supportive therapy. This case highlights the need to rule out malignancies in other organs in patients admitted with severe respiratory symptoms.

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Uncommon Cancers of the Bladder

Siefker-Radtke

Czerniak

Dinney

et al. 2006

Textbook of Uncommon Cancer

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Multimodality Management of Urachal Carcinoma: The M. D. Anderson Cancer Center Experience

Cited by 250 publications

References 11 publications

Differences in survival among patients with urachal and nonurachal adenocarcinomas of the bladder

Differences in survival among patients with urachal and nonurachal adenocarcinomas of the bladder

Endobronchial Metastasis of a Primary Transitional-Cell and Signet-Ring Cell Carcinoma of the Urinary Bladder

Uncommon Cancers of the Bladder

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