Multimodality management of leiomyosarcoma of the cervix

Jayaram, Vijaya Kumar; J, Parikshith; Narayanan, Geeta S; Tiwari, Richa; Veena, R; Shetty, Prathima; Ganesh,; Snehith, Chattakonda Sai; Praisy, Esther

doi:10.3332/ecancer.2018.830

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…Hysterectomy should be the first choice of treatment in these patients according to other studies. Multimodality management may suitable for cervical leiomyosarcoma [ 11 ]. Undifferentiated sarcomas are a rare group of tumors with an aggressive behavior and poor outcomes.…”

Section: Discussionmentioning

confidence: 99%

Sarcoma of the uterine cervix: experience of a single center

Yuan,

Li,

et al. 2024

World J Surg Onc

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Objectives To investigate the clinicopathological characteristics and prognosis of patients with primary sarcoma of the uterine cervix. Methods We identified all patients with primary cervical sarcomas treated at our institution from 2002 to 2020 and analyzed the clinicopathological characteristics and prognosis. Results 34 patients were identified, 7 (20.6%) patients had leiomyosarcoma, 6 (17.6%) had carcinosarcoma, 5 (14.7%) had Ewing sarcoma, 4 (11.8%) had rhabdomyosarcoma, 4 (11.8%) had undifferentiated sarcoma, 2 (5.9%) had adenosarcoma, 2 (5.9%) had endometrial stromal sarcoma, 1 (2.9%) had dermatofibrosarcoma protuberans, 1 (2.9%) had alveolar soft tissue sarcoma and 2 (5.9%) had sarcoma not otherwise specified. The median age of the whole patients was 43.5 years (range, 13–63). The median age of patients with Ewing sarcoma or rhabdomyosarcoma was 22 years (range, 13–39) and 17 years (range, 13–36 years), respectively. The distribution by stage was: stage I in 21 (61.8%) patients, stage II in 4 (11.8%), stage III in 6 (17.6%) and stage IV in 3 (8.8%). Overall, 30 patients (88.2%) received surgical treatment. The median follow-up was 33.3 months (range 3.6–187.3 months). 11 patients died within 2 years after diagnosis, most of them were patients with carcinosarcoma or undifferentiated sarcoma (45.5%, 5/11). In the entire cohort, 2- and 5-year OS were 67.2% and 56.9%, respectively. 5-year OS was 25.0% for undifferentiated sarcoma, 50.0% for rhabdomyosarcoma, 50.0% for carcinosarcoma, 53.3% for Ewing sarcoma, 57.1% for leiomyosarcoma. Conclusion Cervical sarcomas are rare neoplasms with multiple histological subtypes and follow an aggressive course. Prognosis may be associated with tumor histology and stage.

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Section: Discussionmentioning

confidence: 99%

Sarcoma of the uterine cervix: experience of a single center

Yuan,

Li,

et al. 2024

World J Surg Onc

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“…Spindle cell tumours may be sarcomas or carcinomas, and can also be benign [ 6 ], as in the index case. Few cases of spindle cell neoplasm of the cervix are reported in the literature [ [7] , [8] , [9] , [10] , [11] ], limiting the knowledge about its characteristics, and making this case report relevant. The occurrence of only spindle cells in the tumour without the presence of other cells makes this case rare.…”

Section: Discussionmentioning

confidence: 99%

Surgical excision of benign spindle cell neoplasm of the cervix predating miscarriage due to cervical insufficiency: A case report

Nkanyane¹,

Ngene

2022

Case Reports in Women's Health

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“…Radiation therapy is often used to decrease locoregional recurrence. The regimen consists of the administration of external radiotherapy of 50 Gy in 25 fractions followed by 2-3 sessions of brachytherapy 15 . In a retrospective review of 208 patients, it was observed that treatment with adjuvant pelvic radiotherapy decreased the risk of pelvic recurrence 16 .…”

Section: Discussionmentioning

confidence: 99%

Primary leiomyosarcoma of the uterine cervix: A case report of an unusual neoplasia

Sánchez-Villegas¹,

Ruiz-Sánchez²,

Vidal-Gutiérrez³

et al. 2022

RMU

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Primary sarcomas of the cervix are rare neoplasms. Of all diagnosed cervical sarcomas, leiomyosarcomas correspond to 21% of cases. A 43-year-old woman presented with vaginal bleeding, and a pelvic ultrasound showed an image suggestive of a myoma during her approach. She underwent hysterectomy plus salpingo-oophorectomy, and the pathology study reported a high-grade leiomyosarcoma originating from the endocervix. Management with adjuvant radiotherapy was decided on, and 12 months later, she presented a recurrence of the disease, and chemotherapy was started. There is no established optimal treatment, and the available evidence is scarce.

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Multimodality management of leiomyosarcoma of the cervix

Cited by 5 publications

References 16 publications

Sarcoma of the uterine cervix: experience of a single center

Sarcoma of the uterine cervix: experience of a single center

Surgical excision of benign spindle cell neoplasm of the cervix predating miscarriage due to cervical insufficiency: A case report

Primary leiomyosarcoma of the uterine cervix: A case report of an unusual neoplasia

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