Multimodality imaging of hepatocellular carcinoma and intrahepatic cholangiocarcinoma

Abstract

Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are the two most common primary malignant tumors of the liver. The similarities and variations in imaging characteristics that may aid in distinguishing between these two primary tumors will be discussed and outlined in this review. Knowledge of imaging techniques that are currently available would assist in the differentiation between these primary malignancies.

Comprehensive Overview the Role of Glycosylation of Extracellular Vesicles in Cancers

“…Among primary liver cancer, hepatocellular carcinoma (HCC) comprises more than 75% of cases and intrahepatic cholangiocarcinoma (iCCA) comprises more than 10% . Early diagnosis of both HCC and iCCA is critical for enhancing patient outcomes, as advanced-stage disease management is more limited and associated with significant side effects . At present, both the imaging tests and serum marker tests, which are more commonly used in clinical practice, lack perfect specificity and sensitivity.…”

“… 112 Early diagnosis of both HCC and iCCA is critical for enhancing patient outcomes, as advanced-stage disease management is more limited and associated with significant side effects. 126 At present, both the imaging tests and serum marker tests, which are more commonly used in clinical practice, lack perfect specificity and sensitivity. Researchers in related fields are actively developing new diagnostic markers for liver cancer, including studies on EV glycosylation, with the aim of enabling early diagnosis.…”