Multimodality imaging of benign and malignant male breast disease

Madhukar, Megha; Chetlen, Alison L.

doi:10.1016/j.crad.2013.07.007

Cited by 17 publications

(20 citation statements)

References 59 publications

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“…Nowadays, advanced imaging modalities like CT, MRI, and PET are increasingly being used. 5 In our study, the most common condition encountered (Table 4) was gynaecomastia, which was seen in 66.66% of the patients. In most studies, gyanecomastia accounted for up to 80% of male patients presenting to hospitals.…”

Section: Discussionmentioning

confidence: 52%

“…Approach to breast disease in male patients typically mirrors that employed in female patients. [3][4][5] Evaluation of hormonal profile and genetic factors may be further required. 6,7 Because of -toxic masculinity‖, the stigma and misplaced shame associated with lesions of the breast in male patients can have profound psychological impact, so adequate care must be taken when approaching the insecure patient.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological catalogue of male breast diseases

Ramji

2019

Int Surg J

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Background: Though relatively uncommon compared to diseases of the female breast, diseases of the male breast do occur, but are poorly studied. These range from benign lesions to malignant disease. The purpose of this study was to enumerate the various disorders of the male breast encountered in our practice, so as to develop a better understanding of the clinicopathological profile of these conditions.Methods: This was a retrospective study conducted in the Department of Surgery, KIMS Hospital, Bangalore, from September 2017 to September 2018. Male patients treated for disorders of the breast were included in the study. The clinical profile of the patients and the disease conditions were studied.Results: 21 patients were included in the study. The most common presentation was due to swelling, pain or lump in the breast. The most commonly encountered condition was gynaecomastia (66.66%). Primary malignancy of the breast was encountered in 2 cases.Conclusions: The male breast is subjected to various disease conditions. Most presentations are due to aesthetic defects. Rarely, primary malignancy can develop in the male breast. The breast is an often-neglected part of the male anatomy, and hence patients often present late with complications.

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Clinicopathological catalogue of male breast diseases

Ramji

2019

Int Surg J

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“…In addition, skin thickening ( 17 ) is considered a malignant feature in male breast diseases, and further operations should be performed; this is consistent with our study. Moreover, previous studies ( 7 , 19 – 21 ) suggest that calcification, including coarse and punctate calcifications, should be associated with malignancy in men and could be considered benign in females. Similarly, we found calcification to be a significant factor in male breast cancer.…”

Section: Discussionmentioning

confidence: 98%

An Approach Based on Mammographic Imaging and Radiomics for Distinguishing Male Benign and Malignant Lesions: A Preliminary Study

et al. 2021

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PurposeTo develop and validate an imaging-radiomics model for the diagnosis of male benign and malignant breast lesions.MethodsNinety male patients who underwent preoperative mammography from January 2011 to December 2018 were enrolled in this study (63 in the training cohort and 27 in the validation cohort). The region of interest was segmented into a mediolateral oblique view, and 104 radiomics features were extracted. The minimum redundancy and maximum relevance (mRMR) and the least absolute shrinkage and selection operator (LASSO) methods were used to exclude radiomics features to establish the radiomics score (rad-score). Mammographic features were evaluated by two radiologists. Univariate logistic regression was used to select for imaging features, and multivariate logistic regression was used to construct an imaging model. An imaging-radiomics model was eventually established, and a nomogram was developed based on the imaging-radiomics model. Area under the curve (AUC) and decision curve analysis (DCA) were applied to assess the clinical value.ResultsThe AUC based on the imaging model in the validation cohort was 0.760, the sensitivity was 0.750, and the specificity was 0.727. The AUC, sensitivity and specificity based on the radiomics in the validation cohort were 0.820, 0.750, and 0.867, respectively. The imaging-radiomics model was better than the imaging and radiomics models; the AUC, sensitivity, and specificity of the imaging-radiomics model in the validation cohort were 0.870, 0.824, and 0.900, respectively.ConclusionThe imaging-radiomics model created by the imaging characteristics and radiomics features exhibited a favorable discriminatory ability for male breast cancer.

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“…Gynecomastia is usually idiopathic (physiologic) but can be secondary to the effects of certain medications and systemic diseases (Braunstein, 2007;Cuhaci et al, 2014;Deepinder & Braunstein, 2012;He et al, 2019;Johnson & Murad, 2009;Mieritz et al, 2017;Nuttall, 2010;Nuttall et al, 2015;Polat et al, 2019;Sansone et al, 2017). Patients with suspected gynecomastia are usually diagnosed by physical examination (Braunstein, 2007;Cuhaci et al, 2014;Johnson & Murad, 2009;Nuttall, 2010) or, if necessary, may be referred for confirmatory imaging with MG or US (Appelbaum et al, 1999;Chen & Slanetz, 2014;Iuanow et al, 2011;Madhukar & Chetlen, 2013;Tangerud et al, 2016). CT is not usually used as a diagnostic for gynecomastia.…”

Section: Discussionmentioning

confidence: 99%

Incidental Gynecomastia on Thoracic Computed Tomography in Clinical Practice: Characteristics, Radiologic Features, and Correlation With Possible Causes in South Korean Men

Kim

Lee

et al. 2020

Am J Mens Health

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Gynecomastia is a common incidental finding on thoracic computed tomography (CT). This study aimed to retrospectively determine the prevalence, imaging characteristics, and possible causes of incidental gynecomastia on thoracic CT. Records of male patients who underwent thoracic CT in 2015 were reviewed. The size and morphologic types (nodular, dendritic, and diffuse) were recorded for patients with breast glandular tissue larger than 1 cm, and the cutoff value of gynecomastia was defined as 2 cm. Additionally, the possible causes of gynecomastia obtained by reviewing patients’ charts were recorded. CT-depicted gynecomastia was identified in 12.7% (650 of 5,501) of patients. The median size of the breast glandular tissue was 2.5 cm (interquartile range 2.2–3.1), and 36.8% of patients (239 of 650) had unilateral gynecomastia. The age distribution provided a bimodal pattern with two peaks in the age groups from 20 to 29 years old and greater than 70 years old. Chronic liver disease (CLD; p < .001), all stages of chronic kidney disease (CKD; p < .001), and medications ( p = .002) were significantly associated with gynecomastia. Gynecomastia did not correlate with body mass index ( p = .962). The size of breast glandular tissue was identified to be correlated with the morphologic type of breast tissue and the severity of CLD or CKD. The prevalence of incidental gynecomastia seen on thoracic CT was 12.7%. CT-depicted gynecomastia is not associated with obesity but with CLD, CKD, and medications. When gynecomastia is detected on CT, further evaluations and management might be required for patients with a treatable cause.

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Multimodality imaging of benign and malignant male breast disease

Cited by 17 publications

References 59 publications

Clinicopathological catalogue of male breast diseases

Clinicopathological catalogue of male breast diseases

An Approach Based on Mammographic Imaging and Radiomics for Distinguishing Male Benign and Malignant Lesions: A Preliminary Study

Incidental Gynecomastia on Thoracic Computed Tomography in Clinical Practice: Characteristics, Radiologic Features, and Correlation With Possible Causes in South Korean Men

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