Multimodality characteristics of multifocal choroid plexus carcinoma with bilateral calvarial defects in a dog

Abstract

An 8-year-old male intact miniature poodle presented for blindness, obtundation, tetraparesis and vestibular signs. Magnetic resonance imaging (MRI), radiography and ultrasound revealed a left piriform lobe lesion, right cerebellar and left brainstem lesions, hydrocephalus and bilateral calvarial defects. Histopathology confirmed a choroid plexus carcinoma with meningeal and intraventricular metastases. The calvarial defect did not show evidence of necrosis, osteoclastic resorption, inflammation or neoplastic infiltration, reflecting a quiescent calvarial atrophy or dysplasia. The imaging characteristics are indicative of calvarial atrophy secondary to chronic increased intracranial pressure and this is the first report of a calvarial defect of this size.

Persistent fontanelles in Chihuahuas. Part I. Distribution and clinical relevance

“… 2 , 24 , 25 Furthermore, skull bone defects, suggestive of bone atrophy can be a consequence of multiple choroid plexus carcinomas leading to noncommunicating hydrocephalus and increased intracranial pressure. 26 …”

“…2,24,25 Furthermore, skull bone defects, suggestive of bone atrophy can be a consequence of multiple choroid plexus carcinomas leading to noncommunicating hydrocephalus and increased intracranial pressure. 26 In children, several conditions cause delayed anterior fontanelle closure, the most common conditions being increased intracranial pressure, congenital hypothyroidism, Down syndrome, rickets, and achondroplasia causing dwarfism. 4 One-third of the PFs in Chihuahuas, however, occurred at locations distinct from the sites of fontanelles described in children, suggesting that in these dogs, skull defect etiology differed.…”

Cranial solitary osseous plasmacytoma and subjacent amyloid deposition in a dog

“…Based on the imaging diagnosis, ascertaining whether the osseous lesions were a consequence of the left parietal cortex mass or vice versa was difficult. Calvarial erosion, sclerosis, lysis, and hyperostosis associated with meningiomas, carcinomas, and glial cell tumors in companion animals and humans have been reported 10‐14 . Histological examination in this case suggested that the frontal parietal bone mass was the primary lesion and the underlying brain mass was amyloid deposit, presumably a complication of the plasmocytic neoplasia.…”

“…Calvarial erosion, sclerosis, lysis, and hyperostosis associated with meningiomas, carcinomas, and glial cell tumors in companion animals and humans have been reported. [10][11][12][13][14] Histological examination in this case suggested that the frontal parietal bone mass was the primary lesion and the underlying brain mass was amyloid deposit, presumably a complication of the plasmocytic neoplasia. Amyloidosis is histologically characterized by the extracellular deposition of insoluble fibrillar proteins.…”

Persistent fontanelles in Chihuahuas and inter- and intra-rater reliability of fontanelle area measurement in computed tomography images

“…Both forms of acquired bone defects, i.e., bone remodeling and bone atrophy, occur in dogs: In cavalier King Charles spaniels, similarly affected with CM as are Chihuahuas, foramen magnum height increases over time, suggesting active supraoccipital bone remodeling due to cerebellar pulsation [21][22][23]. Furthermore, suggestive of bone atrophy, skull bone defects can occur as a result of multiple choroid plexus carcinomas leading to non-communicating hydrocephalus and increased intracranial pressure [24].…”