Multimodal validation of patient-specific intraventricular flow simulations from 4D echocardiography

Larsson, Daniel H.; Spühler, Jeannette Hiromi; Petersson, Sven; Nordenfur, Tim; Hoffman, Johan; Colarieti-Tosti, Massimiliano; Winter, Reidar; Larsson, Matilda

doi:10.1109/ultsym.2016.7728802

Cited by 3 publications

(1 citation statement)

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“…In combination with the pathway being based on TTE, the following work represents a novel and potentially important contribution to the field. Please note that the following paper represents a significant extension of previous published work by the same group, where preliminary studies of model robustness [25] and initial correspondence to in-vivo measurements [26] were performed.…”

Section: Introductionmentioning

confidence: 96%

Patient-Specific Left Ventricular Flow Simulations From Transthoracic Echocardiography: Robustness Evaluation and Validation Against Ultrasound Doppler and Magnetic Resonance Imaging

Larsson

Spühler

Petersson

et al. 2017

IEEE Trans. Med. Imaging

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The combination of medical imaging with computational fluid dynamics (CFD) has enabled the study of 3-D blood flow on a patient-specific level. However, with models based on gated high-resolution data, the study of transient flows, and any model implementation into routine cardiac care, is challenging. This paper presents a novel pathway for patient-specific CFD modelling of the left ventricle (LV), using 4-D transthoracic echocardiography (TTE) as input modality. To evaluate the clinical usability, two sub-studies were performed. First, a robustness evaluation was performed, where repeated models with alternating input variables were generated for six subjects and changes in simulated output quantified. Second, a validation study was carried out, where the pathway accuracy was evaluated against pulsed-wave Doppler (100 subjects), and 2-D through-plane phase-contrast magnetic resonance imaging measurements over seven intraventricular planes (6 subjects). The robustness evaluation indicated a model deviation of <12%, with highest regional and temporal deviations at apical segments and at peak systole, respectively. The validation study showed an error of <11% (velocities <10 cm/s) for all subjects, with no significant regional or temporal differences observed. With the patient-specific pathway shown to provide robust output with high accuracy, and with the pathway dependent only on 4-D TTE, the method has a high potential to be used within future clinical studies on 3-D intraventricular flow patterns. To this, future model developments in the form of e.g., anatomically accurate LV valves may further enhance the clinical value of the simulations.

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Section: Introductionmentioning

confidence: 96%