Multimodal therapy for adult Wilms’ tumour: an experience from one centre

Li, Jianjun; Haihui, Huang; Shen, Jian; Jiang, Jingjing; Pan, Feng; Yu, Songtao; Kang, Yu; Zhao, Xingxu; Yan, Xiaochu; Liang, Houjie

doi:10.1007/s12094-011-0713-y

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…Although adult WTs have been relatively well described in pathology studies (3,4), imaging data are scanty. However, patients with adult WT have a different prognosis from other renal cell carcinoma (RCC) subtypes.…”

Section: Introductionmentioning

confidence: 99%

CT and MRI imaging features and long-term follow-up of adult Wilms’ tumor

Zhu

et al. 2015

Acta Radiol

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Section: Introductionmentioning

confidence: 99%

CT and MRI imaging features and long-term follow-up of adult Wilms’ tumor

Zhu

et al. 2015

Acta Radiol

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“…[11] Based on this, it is concluded that adults can be cured by paediatric multimodality protocols. [12] National Wilms' Tumour Study (NWTS) and other studies have recommended multimodal approach for the disease with surgery, chemotherapy (Vincristine, actinomycin D and doxorubicin) for 18 to 27 weeks and tumour bed irradiation 10.8 Gy for stage 3 and 4 disease. Additionally, chest irradiation 12 Gy for stage 4.…”

Section: Discussionmentioning

confidence: 99%

Wilms’ Tumour in Young Adult

Arumugam¹,

Kanakasabapathy²,

Kannaiyan³

2016

jemds

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Wilms' tumour also called as nephroblastoma is a malignant renal neoplasm of childhood that arises from remnant of immature kidney. About 80% of Wilms' tumour cases occur before age 5 with a median age of 3.5 years. But adult Wilms' tumour can occur at any age from 16 to 70 years, the median age in young adult is around 24. CASE REPORTA 16-year-old girl came with history of mass right abdomen, which she noticed for 1 week duration; no urinary symptoms. Her recent blood pressure was 140/90 mmHg. Per abdomen a 10 x 9 cm mass palpable in the right lumbar region, surface smooth, firmto-hard in consistency, non-tender, well defined, no bruit. Urine routine examination was normal; urine culture was sterile; renal and liver function tests were within normal limits; Sr. calcium 9.5 mg/dL. CT abdomen plain and contrast showed a 10 x 9 cm heterodense lesion equivocal with renal cell carcinoma and angiomyolipoma. MR angiogram was done. It showed well-defined encapsulated heterointense mass of size 12 x 8 x 7cm, IVC and bilateral renal vein normal. Since findings were inconclusive, we did a CT-guided biopsy and report came as feature positive for small round cell tumour. Hence, proceeded with right radical nephrectomy. The final histopathology report came as Wilms' tumour spindle cell variant. Margins clear and ureter not involved. She was then started on adjuvant chemotherapy Inj. Vincristine 2 mg weekly for 27 weeks. She is on regular followup now. CONCLUSIONWilms' tumour should be considered in a patient who presents with a renal mass with or without loin pain, haematuria especially in young adults. Every attempt should be made to differentiate it from renal cell carcinoma. The outcome for adult Wilms' tumour is steadily improving with current multimodality treatment approach.

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“…Currently, there was no Wilms tumor epidemiological investigation in Indonesia. [2] Multimodal therapies are used to treat Wilms tumor patients in the majority of cases [3,4]. Surgery, chemotherapy, and radiation are administered in stages, which can boost 5-year survival rates by up to 90%.…”

Section: Introductionmentioning

confidence: 99%

Complication of Hollow Organ Perforation after Radical Nephrectomy in Wilms Tumor: A Case Report

Fahada¹,

Kusumawidagdo²

2022

International Journal of Scientific Advances

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The most frequent kidney cancer in children is Wilms tumor, often known as nephroblastoma. The prevalence is low and only representing for approximately 7% of all childhood cancers. The most standard treatment for this tumor is surgery. Complications from surgical care occurred in patients with Wilms tumor who had a radical nephrectomy. Intestinal blockage, hemorrhage, infection, and vascular injury are the most common surgical consequences. The purpose of this case report is to describe the incidence of perforation of hollow organs after radical nephrectomy in the case of Wilms tumor in a child aged 2 years and 6 months after neoadjuvant chemotherapy, who later developed generalized peritonitis due to ileal anastomoses leakage.

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Multimodal therapy for adult Wilms’ tumour: an experience from one centre

Abstract: The results of this report suggest that histological anaplasia might be an adverse prognostic factor for AWT. Proper application of the diagnostic and therapeutic regimens established for children may improve the prognosis of adult patients with WT.

Cited by 4 publications

References 18 publications

CT and MRI imaging features and long-term follow-up of adult Wilms’ tumor

CT and MRI imaging features and long-term follow-up of adult Wilms’ tumor

Wilms’ Tumour in Young Adult

Complication of Hollow Organ Perforation after Radical Nephrectomy in Wilms Tumor: A Case Report

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