“…However, these traditional machine learning methods cannot take raw features from large, annotated datasets and use them to identify the patterns buried inside them. Deep learning algorithms is a powerful approach for learning complex patterns and has led to multiple performance breakthroughs in many research fields, including computer vision [ 32 , 33 , 34 , 35 , 36 , 37 ] and natural language processing [ 38 , 39 , 40 ]. However, very few prediction models have implemented the concept of deep learning into the sgRNA off-target propensity prediction problem.…”