Multimodal Single‐Cell Sequencing of B Cells in Primary Sjögren's Syndrome
Gustav Arvidsson,
Paulo Czarnewski,
Alina Johansson
et al.
Abstract:ObjectiveB cells are important in the pathogenesis of primary Sjögren's syndrome (pSS). Patients positive for SSA/SSB autoantibodies are more prone to systemic disease manifestations and adverse outcomes. We aimed to determine the role of B cell composition, gene expression and B cell receptor (BCR) usage in pSS subgroups stratified for SSA/SSB antibodies.MethodsOver 230 000 B cells were isolated from peripheral blood of pSS patients (n = 6 SSA‐, n = 8 SSA+ single positive and n = 10 SSA/SSB+ double positive) … Show more
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