Multimodal retinal imaging of familial amyloid polyneuropathy

Latasiewicz, Marta; Sala‐Puigdollers, Anna; González-Ventosa, A.; Millá, Elena; Civera, Alfredo Adán

doi:10.1080/13816810.2019.1666413

Cited by 13 publications

(19 citation statements)

References 22 publications

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Section: Discussionsupporting

confidence: 85%

“…This may be explained by amyloid deposition directly within the stroma. Ischemia seemed not to play a role, at least in age groups and disease stages included, because LA is similar to the control group and this corroborates the theory of Latasiewicz et al 11 When hTTRA patients were compared according to pupil types, there was no statistical difference in the OCT-EDI parameters in the unadjusted analysis, although, the mixed linear model revealed a higher CVI for patients with scalloped pupil. This conse-quently reinforces the presence of an independent TTR production inside of the eye because more severe ocular disease (represented by a scalloped pupil) was C, in 1-mm-width central sector; G, in the full 5-mm-width image; N, in the 1-mm-width nasal sector; T, in the 1-mm-width temporal sector.…”

Section: Discussionsupporting

confidence: 82%

“…10 Finally, in 2019, Latasiewicz et al, showed that the choroidal thickness (CT) tended to be slightly thinned, although, the ischemia seemed to be more important than the systemic amyloid deposition for the CT because most patients had undergone liver transplantation, which naturally eliminates the source of the faulty TTR in the systemic circulation and the choroid. 11 However, this last analysis included only eight patients and the choroid was evaluated with OCT without enhanced depth imaging (EDI) protocol.…”

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confidence: 99%

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Choroidal Involvement in Hereditary Transthyretin Amyloidosis Patients

Marta

Marques

Ferreira

et al. 2022

Retina

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Purpose: To compare the choroidal characteristics between the eyes of patients with and without hereditary transthyretin amyloidosis.Methods: Case-control observational study with choroidal thickness and vasculature evaluation by optical coherence tomography with enhanced depth imaging protocol of the macula.Results: The study included 332 eyes: 166 eyes of hereditary transthyretin amyloidosis patients and 166 eyes of healthy patients. Mean age was similar between groups (P = 0.979). For hereditary transthyretin amyloidosis patients, on average, in all sectors analyzed (in the full 5 mm-width image [G] and also in 1-mm-width central [C], nasal [N], and temporal [T] sectors), there was a higher stromal area, a lower choroidal thickness, and a lower choroidal vascularity index, compared with the control group. The linear mixed models revealed no differences according to the systemic treatment groups.Conclusion: Hereditary transthyretin amyloidosis patients showed statistically significant differences in choroidal characteristics, compared with eyes without pathology. These age-related and statistically significant changes compared with the healthy eyes may help in the future to better monitor the systemic hereditary transthyretin amyloidosis disease and complement other systemic evaluations, including on clinical trials to analyze more objectively, the results of new therapies.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 82%

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confidence: 99%

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Choroidal Involvement in Hereditary Transthyretin Amyloidosis Patients

Marta

Marques

Ferreira

et al. 2022

Retina

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“…Clinical and preclinical data support that retinal Aβ deposition correlates with and may even precede cerebral Aβ deposition 7,13,16–19 . Modern technology was recently developed to image retinal amyloidosis in patients with AD, 13,20–22 as fluorescence signal and other retinal features may aid in predicting cerebral amyloid status 17,23 . One of the contemporary imaging modalities is curcumin‐enhanced retinal fluorescence imaging that was pioneered as a useful non‐invasive tool for retinal Aβ plaque detection in animals and humans 7,9,13 …”

Section: Introductionmentioning

confidence: 99%

Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline

Dumitrascu

Lyden

Torbati

et al. 2020

Alzheimer's & Dementia: Diagnosis, Assessment &

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Introduction Despite advances in imaging retinal amyloidosis, a quantitative and topographical investigation of retinal amyloid beta burden in patients with cognitive decline has never been reported. Methods We used the specific amyloid‐binding fluorophore curcumin and laser ophthalmoscopy to assess retinal amyloid imaging (RAI) in 34 patients with cognitive decline. We automatically quantified retinal amyloid count (RAC) and area in the superotemporal retinal sub‐regions and performed correlation analyses with cognitive and brain volumetric parameters. Results RAC significantly and inversely correlated with hippocampal volume (HV; r = ‐0.39, P = .04). The proximal mid‐periphery (PMP) RAC and RA areas were significantly greater in patients with Montreal Cognitive Assessment (MOCA) score < 26 ( P = .01; Cohen d = 0.83 and 0.81, respectively). PMP showed significantly more RAC and area in subjects with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared to cognitively normal ( P = .04; Cohen d = 0.83). Conclusion Quantitative RAI is a feasible technique and PMP RAC may predict HV. Future larger studies should determine RAI's potential as a biomarker of early AD.

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“…Although suprachoroidal hemorrhage tends to happen more frequently during intraocular surgeries following the previous vitrectomy due to the lack of vitreous support and easier fluctuation of intraocular pressure, we speculate that amyloid induced vasculopathy in the choroid could also be a triggering factor to induce the suprachoroidal hemorrhage with the same pathophysiology of brain vascular changes. Amyloid retinal and choroidal angiopathy tends to appear late in the course of the disease, and choroidal amyloid depositions were frequently observed in the choroidal arterial vasculature ( 11 , 12 ). Poignet et al reported three patients with vitreous amyloidosis who all had choroidal angiopathy in late indocyanine green angiography (ICG) ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Vitreous Amyloidosis Caused by a TTR Lys55Asn Mutation With Intraoperative Suprachoroidal Hemorrhage

Wang

Zhang

et al. 2022

Front. Med.

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We report a vitreous amyloidosis patient with white vitreous opacities (footplates) adhering to the posterior lens capsule. A positive Congo-red stain and transthyretin (TTR) Lys55Asn mutation confirmed the diagnosis of vitreous amyloidosis. Optical coherence tomography (OCT) revealed fern-like material adhering to the the posterior pole retinal surface in both eyes. Visual acuity significantly improved after the first vitrectomy, but vitreous opacities recurred 4 years later. The patient appeared to have aggravated sensorimotor neuropathy and severe autonomic dysfunction at the same time. He developed intraoperative suprachoroidal hemorrhage during the second vitrectomy.

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Multimodal retinal imaging of familial amyloid polyneuropathy

Cited by 13 publications

References 22 publications

Choroidal Involvement in Hereditary Transthyretin Amyloidosis Patients

Choroidal Involvement in Hereditary Transthyretin Amyloidosis Patients

Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline

Case Report: Vitreous Amyloidosis Caused by a TTR Lys55Asn Mutation With Intraoperative Suprachoroidal Hemorrhage

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