Multimodal optical monitoring of auto and allografts of skin on a burn wound

Ryabkov, M. G.; Бесчастнов, В. В.; Petrova, K. S.; Peretyagin, P. V.; Orlova, Anna; Kostyuk, Aleksey B.; Turchin, Ilya V.; Bugrova, Marina L.; Arefiev, Igor Yu

doi:10.1117/12.2609580

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…However, the problem of early non-invasive diagnosis of split skin allograft rejection has not been solved so far. The aim of this study is to investigate the state of auto-and allografts of the skin in a burn wound using different optical modalities, DRS, OCT/OCA, and LDF, which provide complementary information about the tissue state [20]. While DRS gives information on the physiological status of biological tissue from chromophore content (blood and water content and oxygenation), OCT provides information on tissue structure, and OCA and LDF provide data on blood perfusion.…”

Section: Introductionmentioning

confidence: 99%

Multimodal Optical Monitoring of Auto- and Allografts of Skin on a Burn Wound

et al. 2023

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The aim of the study was to investigate the dynamics of the state of allo- and autografts of skin on a wound using optical modalities: diffuse reflectance spectroscopy (DRS), optical coherence tomography (OCT), and laser Doppler flowmetry (LDF). A deep thermal burn was simulated in 24 rats covering 20% of the body surface. On day 3 after the injury, a fascial necrectomy of two 500 mm2 areas on the left and right sides of the midline of the animal body were excised. Allografts and autografts were placed in the centers of these areas. Optical measurements of grafts were performed on the 0, 3rd, 6th, 10th, and 13th days after transplantation. The allografts demonstrated a pronounced decrease in oxygenation, blood content, and perfusion compared to autografts on the 6th day; in the following days of observation, these values returned to the average values of autografts. Water content gradually decreased from the beginning to the end of observation. In conclusion, optical diagnostics revealed changes in the morphological microstructure, the rate of restoration of blood circulation, and oxygen exchange in the early stages, specific for the allo- and autograft.

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Section: Introductionmentioning

confidence: 99%

Multimodal Optical Monitoring of Auto- and Allografts of Skin on a Burn Wound

et al. 2023

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“…Assessment of the structural and qualitative condition of the skin vessels is the most important task of modern microbiology [1,2,3,4]. Identification of vessels, their types and caliber is necessary not only to determine the degree of tissue damage, but also to assess the degree of granulation tissue activity and skin graft vascularization after surgical treatment of a burn [5,6].…”

Section: Introductionmentioning

confidence: 99%

Experimental identification of arterial and venous vessels of the skin by 3D optical coherence tomography

Petrova¹,

Ryabkov²,

Петрова³

et al. 2022

Optics in Health Care and Biomedical Optics XII

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The degree and variants of structural changes in the vessels of the skin are important pathomorphological signs of the degree of tissue damage and potential possibilities and the course of its regeneration in various skin injuries, including burns. Objective: to identify arteries and veins with 3D optical coherence tomography during the experiment, describing their distinctive features. Materials and methods. To identify the vessels on OCT images of the skin, the rabbit ear was examined in vivo over the superficially located central artery and marginal vein and the vascular-free zone with a needle mark in the lumen of the vessel. Histo-tomographic comparisons were performed. Result. OCT signs of arterial and venous vessels are formulated.

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Multimodal optical monitoring of auto and allografts of skin on a burn wound

Cited by 2 publications

References 13 publications

Multimodal Optical Monitoring of Auto- and Allografts of Skin on a Burn Wound

Multimodal Optical Monitoring of Auto- and Allografts of Skin on a Burn Wound

Experimental identification of arterial and venous vessels of the skin by 3D optical coherence tomography

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