Multimodal locoregional procedures for cancer pain management: a literature review

Iezzi, Roberto; Kovács, György; Dimov, V.; Contegiacomo, Andrea; Posa, Alessandro; Efthymiou, Evgenia; Lancellotta, Valentina; Rodolfino, Elena; Punzi, Ernesto; Trajkovski, Zoran B; Valentini, Vincenzo; Manfredi, Riccardo; Filippiadis, Dimitrios

doi:10.1259/bjr.20220236

Cited by 3 publications

(2 citation statements)

References 90 publications

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“…The major advantages of cryoablation are the visibility of the ice ball on ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MR), the lower sensitivity to heat-sink effect compared to RFA [ 29 ], and the analgesic property of cold energy, which is associated with reduced intra- and postprocedural pain [ 30 , 31 , 32 , 33 ].…”

Section: Loco-regional Therapiesmentioning

confidence: 99%

Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives

Punzi

Carrubba

Contegiacomo

et al. 2023

Life

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Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease; patients’ long-term survival is strictly linked to the surgical resection of the tumor but only a minority of patients (2–3%) have a resectable disease at diagnosis. In patients with surgically unresectable disease, interventional radiology is taking on an increasing role in treatment with the application of loco-regional percutaneous therapies. The primary purposes of this narrative review are to analyze the safety and efficacy of ablative techniques in the management of borderline resectable and locally advanced diseases and to underline the role of the interventional radiologist in the management of patients with distant metastases. The secondary purpose is to focus on the synergy between immunotherapy and ablative therapies.

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Section: Loco-regional Therapiesmentioning

confidence: 99%

Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives

Punzi

Carrubba

Contegiacomo

et al. 2023

Life

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“…The duration of the analgesic effect of radiation is on average 3-4 months, and in about half of the patients the pain at the irradiated site progresses after this time. In these cases, repeated radiotherapy can be effective in 50-60% of patients, and 16-28% of patients can experience complete pain relief 10 .…”

Section: Brief Communicationmentioning

confidence: 99%

Novel Techniques of Radiotherapy in the Management of Oncologic Pain

Assis Pellizzon

2023

Lat. Am. J. Palliat. Care

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Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Oncologic pain (OP), in general, increases with disease progression. Moderate or severe intensity OP occurs in around 30% of cancer patients receiving treatment and in 60% to 90% of patients with advanced cancer. Radiotherapy (RT) is an effective non-pharmacological method of treatment of OP. Two new techniques of RT are available for pain control: ablative RT for oligometastatic disease and lattice RT, for voluminous tumors. We will review their efficacy and results, concluding that OP is a complex biologic phenomenon and its successful treatment requires careful assessment of its nature, understanding the different types and patterns. Specific pain management with new radiation techniques can be effective and provide good pain control, allowing the reduction of analgesics use, improving the quality of life.

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Liquid nitrogen-based cryoablation: complication rates for lung, bone, and soft tissue tumors cryoablation

Orsi,

Hamiddin,

Sattin

et al. 2024

British Journal of Radiology

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Objective This study aimed to assess the complication rate during and 24 hours after cryoablation in lung, bone, and soft tissue tumors. Methods We reviewed complications in a total of 85 consecutive patients who underwent cryoablation using a liquid nitrogen-based system in various lesions between April 2017 and October 2022. There were no liver and renal lesions. Complications were categorized using the Society of Interventional Radiology classification. Results Eighty-five patients were treated for 96 lesions in the bone (36.4%; 35 of 96), lung (18.8%; 18 of 96), and soft tissue (44.8%; 43 of 96). The primary technical success rate was 97.7% (83 of 85). The total grade 2 and 1 complication rates were 5.2% (5/96) and 20.8% (20/96), respectively. Two patients had asymptomatic pulmonary embolisms incidentally noted at the 24-hour follow-up computed tomography (grade 2). The most frequent complications were simple and hemorrhagic pleural effusions (18.7%; 18 of 96). Lung procedures had the highest complication rate, where 13 patients (72.2%; 13 of 18) reported complications, including 2 cases of symptomatic hydropneumothorax requiring drainage (grade 2) and an additional 2 days of hospital stay. Eight patients (24.2%; 8 of 33) with bone lesions and 4 (9.3%; 4 of 43) with soft tissue lesions experienced complications. Conclusion Cryoablation using a liquid nitrogen-based system is safe, with only minor complications observed. Advances in knowledge This study provides data on the safety of liquid nitrogen-based percutaneous cryoablation in tumors located in lung, in bones and in soft tissues. Despite using larger diameter cryoprobes than those typically reported with argon-based system, our experience shows that complications are mostly low and comparable in frequency and severity.

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Multimodal locoregional procedures for cancer pain management: a literature review

Cited by 3 publications

References 90 publications

Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives

Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives

Novel Techniques of Radiotherapy in the Management of Oncologic Pain

Liquid nitrogen-based cryoablation: complication rates for lung, bone, and soft tissue tumors cryoablation

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