Multimodal imaging of sclerochoroidal calcification associated with choroidal neovascular membrane

Choroidal neovascularization complicating sclerochoroidal calcifications

“…Nevertheless, CNV seems to complicate the course of SCC in advanced age, since all the described cases are above 70. 7 , 8 , 9 , 10 , 11 , 12 OCT angiography in one case demonstrated choroidal ischemia in the area of SCC and it is possible that the choroidal hypoperfusion or RPE compression by SCC can lead to CNV formation. 13 Of interest is the close similarity between CNV in choroidal osteoma and CNV in SCC, knowing that up to half of eyes with choroidal osteoma can develop CNV and are best treated with anti-VEGF injections.…”

“… 1 , 2 , 3 , 4 , 5 , 6 CNV may complicate the course of SCC, showing variable clinical outcomes. 3 , 5 , 7 , 8 , 9 , 10 , 11 When the CNV is asymptomatic and distant from the fovea, no treatment may be required, a frequent monitoring being sufficient to ascertain the stabilization of the CNV. 5 , 7 On the other hand, several treatment modalities are available when CNV showed exudative manifestations, including laser photocoagulation, photodynamic therapy and anti-VEGF injections.…”

“…3 , 5 , 7 , 8 , 9 , 10 , 11 When the CNV is asymptomatic and distant from the fovea, no treatment may be required, a frequent monitoring being sufficient to ascertain the stabilization of the CNV. 5 , 7 On the other hand, several treatment modalities are available when CNV showed exudative manifestations, including laser photocoagulation, photodynamic therapy and anti-VEGF injections. 7 , 8 , 9 , 10 , 11 , 12 Intravitreal anti-VEGF treatment was used to stabilize the SCC-related CNV activity in a few cases, with variable results.…”

“…5 , 7 On the other hand, several treatment modalities are available when CNV showed exudative manifestations, including laser photocoagulation, photodynamic therapy and anti-VEGF injections. 7 , 8 , 9 , 10 , 11 , 12 Intravitreal anti-VEGF treatment was used to stabilize the SCC-related CNV activity in a few cases, with variable results. 10 , 11 , 12 In particular, in a single case, a series of bevacizumab injections failed to control the CNV-related retinal exudation, 11 whereas in another case the macular edema and subretinal fluid was reduced after an unspecified number of intravitreal anti-VEGF injections in combination with a single posterior subtenon injection of triamcinolone acetonide.…”

Diagnosis and Management Strategies in Sclerochoroidal Calcification: A Systematic Review

“…In two studies, CNV associated with SCC was demonstrated using OCTA. 51,55 In the other case report, OCTA features of SCC were described in detail. In this case, the outer retinal and choroidal slabs demonstrated hyporeflectivity in the lesion area probably because of the shadowing effect of calcium.…”