Multimodal imaging of repetition priming: Using fMRI, MEG, and intracranial EEG to reveal spatiotemporal profiles of word processing

McDonald, Carrie R.; Thesen, Thomas; Carlson, Chad; Blumberg, Mark S.; Girard, Holly M.; Trongnetrpunya, Amy; Sherfey, Jason; Devinsky, Orrin; Kuzniecky, Rubin; Dolye, Werner K.; Cash, Sydney S.; Leonard, Matthew K.; Hagler, Donald J.; Dale, Anders M.

doi:10.1016/j.neuroimage.2010.06.069

Cited by 76 publications

(57 citation statements)

References 46 publications

(59 reference statements)

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“…Review of the literature shows that extensive and systematic ERP research has been conducted on English and other alphabetic scripts in the past three decades, however, no study has reported effects similar to the present N200 and in particular its repetition enhancement effect [37][38][39][40][41][42][43]. A convincing case is that Xu et al [33] followed exactly the same paradigm as a study on English and Spanish [44] except using Chinese words and Chinese participants.…”

Section: Discussionmentioning

confidence: 72%

Centro-parietal N200: An event-related potential component specific to Chinese visual word recognition

Zhang

Fang

et al. 2012

Chin. Sci. Bull.

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Almost all written languages currently used in the world are alphabetic or phonologically-based scripts (e.g., English) whose word recognition involves discrimination of one-dimensional linear combinations of several dozens of letters or phonological units, except written Chinese whose vocabulary consists of a large number of block characters, the analysis of which relies on the extraction of 2-dimensional form information at multiple levels including radical, character, and multiple-character word. Whether the dramatic contrast between the 2 types of orthography leads to distinctive mental processes is a fundamental question in psycholinguistic research unanswered in the past three decades. Using event-related potentials and visual lexical decision tasks, we asked native Chinese speakers to discriminate between real Chinese words and pseudo-or non-words and observed a widespread negative deflection with centro-parietal focus elicited 200 ms post-stimulus onset. This N200 response showed a clear and large amplitude enhancement upon word repetition and seems to be specific to Chinese as no similar effects had been reported in word recognition studies involving alphabetic scripts under similar experimental conditions. Further evidence showed that this N200 could not be attributed to non-linguistic sensori-perceptual processes, nor phonological or semantic processes, but likely reflects very early identification of the orthography of individual words involving extensive and higher-level visual analysis. Recently the first author proposed a meaning-spelling theory of written Chinese vocabulary proposing that the Chinese and alphabetic scripts are the only 2 possible logical types of mature human writing systems, and that the former is more thoroughly a visual language compared with the latter and thus shall emphasize more of visual processing. Reinforcing each other, the meaning-spelling theory and the discovery of the centro-parietal N200 reveal the uniqueness of Chinese both theoretically and empirically, and provide strong arguments for the intrinsic distinction between written Chinese and alphabetic scripts.

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Section: Discussionmentioning

confidence: 72%

Centro-parietal N200: An event-related potential component specific to Chinese visual word recognition

Zhang

Fang

et al. 2012

Chin. Sci. Bull.

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“…The present results are based on FreeSurfer estimates of morphometry, however the findings are likely to generalize to other structural estimation algorithms as well (e.g., ANTs, FSL, CIVET). As mentioned above, biased structural imaging may impair within‐ and between‐modality image registration, but also functional localization methods, and analyses that require accurate mapping to anatomical surfaces [McDonald et al, 2010; Wig et al, 2014], all of which often rely on accurate characterization of brain anatomy. Such problems with image registration may be exacerbated in cross‐cohort comparisons by warping T1w anatomical scans to a template image with varying degrees of success due to differences in motion‐related artifacts.…”

Section: Discussionmentioning

confidence: 99%

Motion‐related artifacts in structural brain images revealed with independent estimates of in‐scanner head motion

Savalia

Agres

Chan

et al. 2016

Human Brain Mapping

170

189

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Motion‐contaminated T1‐weighted (T1w) magnetic resonance imaging (MRI) results in misestimates of brain structure. Because conventional T1w scans are not collected with direct measures of head motion, a practical alternative is needed to identify potential motion‐induced bias in measures of brain anatomy. Head movements during functional MRI (fMRI) scanning of 266 healthy adults (20–89 years) were analyzed to reveal stable features of in‐scanner head motion. The magnitude of head motion increased with age and exhibited within‐participant stability across different fMRI scans. fMRI head motion was then related to measurements of both quality control (QC) and brain anatomy derived from a T1w structural image from the same scan session. A procedure was adopted to “flag” individuals exhibiting excessive head movement during fMRI or poor T1w quality rating. The flagging procedure reliably reduced the influence of head motion on estimates of gray matter thickness across the cortical surface. Moreover, T1w images from flagged participants exhibited reduced estimates of gray matter thickness and volume in comparison to age‐ and gender‐matched samples, resulting in inflated effect sizes in the relationships between regional anatomical measures and age. Gray matter thickness differences were noted in numerous regions previously reported to undergo prominent atrophy with age. Recommendations are provided for mitigating this potential confound, and highlight how the procedure may lead to more accurate measurement and comparison of anatomical features. Hum Brain Mapp 38:472–492, 2017. © 2016 Wiley Periodicals, Inc.

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“…The underlying task followed an event-related, semantic judgment task where participants pressed a button with their left index finger each time a target word (i.e., name of an animal; n = 24 target words per run), interspersed with new words, repeating words, and false font sequences, appeared on the screen. A similar, block-design implementation of this task is detailed in McDonald et al (2010). In the event-related design, a stimulus appeared on the screen each 1.5-3 sec (M inter-stimulus interval = 1.9 sec).…”

Section: Task-regressed Hippocampal Functional Connectivitymentioning

confidence: 99%

Functional Connectivity of the Hippocampus in Temporal Lobe Epilepsy: Feasibility of a Task-Regressed Seed-Based Approach

et al. 2013

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Objective: Resting-state functional connectivity (FC) has revealed marked network dysfunction in patients with temporal lobe epilepsy (TLE) compared to healthy controls. However, the nature and the location of these changes have not been fully elucidated nor confirmed by other methodologies. We assessed the presence of hippocampal FC changes in TLE based on the low frequency residuals of task-related functional magnetic resonance imaging data after the removal of task-related activation [i.e., task-regressed functional connectivity MRI (fcMRI)]. Method: We employed a novel, task-regressed approach to quantify hippocampal FC, and compare hippocampal FC in 17 patients with unilateral TLE (9 left) with 17 healthy controls. Results: Our results suggest widespread FC reductions in the mesial cortex associated with the default mode network (DMN), and some local FC increases in the lateral portions of the right hemisphere. We found more pronounced FC decreases in the left hemisphere than in the right, and these FC decreases were greatest in patients with left TLE. Moreover, the FC reductions observed between the hippocampus and posterior cingulate, inferior parietal, paracentral regions are in agreement with previous resting state studies. Conclusions: Consistent with the existing literature, FC reductions in TLE appear widespread with prominent reductions in the medial portion of the DMN. Our data expand the literature by demonstrating that reductions in FC may be greatest in the left hemisphere and in patients with left TLE. Overall, our findings suggest that task-regressed FC is a viable alternative to resting state and that future studies may extract similar information on network connectivity from already existing datasets.

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Multimodal imaging of repetition priming: Using fMRI, MEG, and intracranial EEG to reveal spatiotemporal profiles of word processing

Cited by 76 publications

References 46 publications

Centro-parietal N200: An event-related potential component specific to Chinese visual word recognition

Centro-parietal N200: An event-related potential component specific to Chinese visual word recognition

Motion‐related artifacts in structural brain images revealed with independent estimates of in‐scanner head motion

Functional Connectivity of the Hippocampus in Temporal Lobe Epilepsy: Feasibility of a Task-Regressed Seed-Based Approach

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