Abstract:Multiple neuropathological changes are involved in Alzheimer's disease (AD). AD hallmark biomarkers are amyloid-beta, tau pathology, and neuronal and synaptic loss. Other possible brain tissue-related biomarkers, such as iron and myelin content in the brain, are less frequently studied. Thanks to quantitative MRI (qMRI), tissue parameters such as magnetization transfer (MT), effective transverse relaxation (R2*), and proton density (PD) can be determined quantitatively, enabling the detection of microstructura… Show more
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