Multimodal imaging of bone metastases: From preclinical to clinical applications

Ellmann, Stephan; Beck, Michael; Kuwert, Torsten; Uder, Michael; Bäuerle, Tobias

doi:10.1016/j.jot.2015.07.004

Cited by 13 publications

(6 citation statements)

References 107 publications

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“…In the present case, from a clinical point of view, based on the patient's advanced age and particularly, the history of preceding breast cancer, the development of a bone metastasis in the ill-defined osteolytic finger lesion may be considered, despite its rarity. Bone metastases can appear in any pattern on radiographic findings using X-rays (24). Osseous metastases typically display T1 low-signal intensity, T2 high-signal intensity, and gadolinium enhancement, as were found in our case (25).…”

Section: Discussionsupporting

confidence: 65%

Coexistence of giant cell tumor of tendon sheath and enchondroma in the middle phalanx of the little finger mimicking a malignant tumor: A case report

et al. 2018

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Giant cell tumor of the tendon sheath is a type of slow-growing benign soft tissue tumor that typically arises from the synovium of the tendon sheath. Enchondroma is a benign bone tumor comprising of mature hyaline cartilage that centrally develops within the tubular bone. While giant cell tumor of the tendon sheath or enchondroma are common benign soft tissue and bone tumors, respectively the simultaneous occurrence of these tumors in the same region of the hand is exceedingly rare, and it can mimic a malignant tumor, thereby making the diagnosis more challenging. Herein, we report an unusual imaging presentation of the coexistence of these tumors in the middle phalanx of the little finger, which to the best of our knowledge has not been previously reported, and this initially present as a single intrinsic osseous lesion mimicking malignancy. The coexistence of these tumor types must be considered in the differential diagnosis of an intramedullary lytic lesion with a poor margin associated with a soft tissue mass of the fingers, and a meticulous preoperative magnetic resonance imaging investigation was required.

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Section: Discussionsupporting

confidence: 65%

Coexistence of giant cell tumor of tendon sheath and enchondroma in the middle phalanx of the little finger mimicking a malignant tumor: A case report

et al. 2018

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“…The adaptability it confers, with the operator specifying the features (attraction points) to consider in the images, could be a significant advantage with acquisition protocols optimized to measure particular parameters and not trustable over the entire images [42]. While the method was primarily designed to bring novel possibilities for multiparameter descriptions of the knee joint in future works [4,5], it could certainly prove useful for a range of pathologies that would benefit from a more comprehensive characterization of the tissues using serial imaging, including oncological, inflammatory, and metabolic applications [43][44][45][46].…”

Section: Discussionmentioning

confidence: 99%

An Expert-Supervised Registration Method for Multiparameter Description of the Knee Joint Using Serial Imaging

Babel

Omoumi

Cosendey

et al. 2022

JCM

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As knee osteoarthritis is a disease of the entire joint, our pathophysiological understanding could be improved by the characterization of the relationships among the knee components. Diverse quantitative parameters can be characterized using magnetic resonance imaging (MRI) and computed tomography (CT). However, a lack of methods for the coordinated measurement of multiple parameters hinders global analyses. This study aimed to design an expert-supervised registration method to facilitate multiparameter description using complementary image sets obtained by serial imaging. The method is based on three-dimensional tissue models positioned in the image sets of interest using manually placed attraction points. Two datasets, with 10 knees CT-scanned twice and 10 knees imaged by CT and MRI were used to assess the method when registering the distal femur and proximal tibia. The median interoperator registration errors, quantified using the mean absolute distance and Dice index, were ≤0.45 mm and ≥0.96 unit, respectively. These values differed by less than 0.1 mm and 0.005 units compared to the errors obtained with gold standard methods. In conclusion, an expert-supervised registration method was introduced. Its capacity to register the distal femur and proximal tibia supports further developments for multiparameter description of healthy and osteoarthritic knee joints, among other applications.

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“…In a recent review, novel options for the measurability of bone metastases were summarized, including functional and metabolic parameters from magnetic resonance imaging (MRI) and positron emission tomography (PET) [15]. Quantitative approaches for the non-invasive characterization of bone metastases are needed to (i) understand the pathophysiology of osseous lesions during bone colonization, (ii) enable early diagnosis of skeletal lesions, and (iii) assess treatment response in metastasis to bone [16,17].…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Characterization of Experimental Bone Metastasis in Obesity Using Multiparametric MRI and PET/CT

Gregoric

Gaculenko

Nagel

et al. 2022

Cancers

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The growth of primary tumors and metastases is associated with excess body fat. In bone metastasis formation, the bone marrow microenvironment, and particularly adipocytes, play a pivotal role as growth mediators of disseminated tumor cells in the bone marrow. The aim of the present study is to non-invasively characterize the pathophysiologic processes in experimental bone metastasis resulting from accelerated tumor progression within adipocyte-rich bone marrow using multimodal imaging from magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT). To achieve this, we have employed small animal models after the administration of MDA-MB 231 breast cancer and B16F10 melanoma cells into the bone of nude rats or C57BL/6 mice, respectively. After tumor cell inoculation, ultra-high field MRI and µPET/CT were used to assess functional and metabolic parameters in the bone marrow of control animals (normal diet, ND), following a high-fat diet (HFD), and/or treated with the peroxisome proliferator-activated receptor-gamma (PPARγ) antagonist bisphenol-A-diglycidylether (BADGE), respectively. In the bone marrow of nude rats, dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI), as well as [18F]fluorodeoxyglucose-PET/CT([18F]FDG-PET/CT), was performed 10, 20, and 30 days after tumor cell inoculation, followed by immunohistochemistry. DCE-MRI parameters associated with blood volume, such as area under the curve (AUC), were significantly increased in bone metastases in the HFD group 30 days after tumor cell inoculation as compared to controls (p < 0.05), while the DWI parameter apparent diffusion coefficient (ADC) was not significantly different between the groups. [18F]FDG-PET/CT showed an enhanced glucose metabolism due to increased standardized uptake value (SUV) at day 30 after tumor cell inoculation in animals that received HFD (p < 0.05). BADGE treatment resulted in the inversion of quantitative DCE-MRI and [18F]FDG-PET/CT data, namely a significant decrease in AUC and SUV in HFD-fed animals as compared to ND-fed controls (p < 0.05). Finally, immunohistochemistry and qPCR confirmed the HFD-induced stimulation in vascularization and glucose activity in murine bone metastases. In conclusion, multimodal and multiparametric MRI and [18F]FDG-PET/CT were able to derive quantitative parameters in bone metastases, revealing an increase in vascularization and glucose metabolism following HFD. Thus, non-invasive imaging may serve as a biomarker for assessing the pathophysiology of bone metastasis in obesity, opening novel options for therapy and treatment monitoring by MRI and [18F]FDG-PET/CT.

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Multimodal imaging of bone metastases: From preclinical to clinical applications

Cited by 13 publications

References 107 publications

Coexistence of giant cell tumor of tendon sheath and enchondroma in the middle phalanx of the little finger mimicking a malignant tumor: A case report

Coexistence of giant cell tumor of tendon sheath and enchondroma in the middle phalanx of the little finger mimicking a malignant tumor: A case report

An Expert-Supervised Registration Method for Multiparameter Description of the Knee Joint Using Serial Imaging

Non-Invasive Characterization of Experimental Bone Metastasis in Obesity Using Multiparametric MRI and PET/CT

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