Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles

Abstract

In this work, a nanoscale reduced graphene oxide-iron oxide nanoparticle (RGO-IONP) complex is noncovalently functionalized with polyethylene glycol (PEG), obtaining a RGO-IONP-PEG nanocomposite with excellent physiological stability, strong NIR optical absorbance, and superparamagnetic properties. Using this theranostic nanoprobe, in-vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging are carried out, uncovering high passive tumor targeting, which is further used for effective photothermal ablation of tumors in mice.

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

“…Compared to other conventional therapeutic techniques, PTT boasts many merits such as the simplicity, minimal invasiveness, low incidence of complications, as well as the high spatial and temporal precision of NIR light 8, 9, 10, 11. Various types of nanoagents have been explored to attain better PTT performance12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 and in the treatment, intravenous injection of the nanoagents (to mice, for example) is followed by high‐power NIR laser irradiation for ablation 25, 26, 27, 28, 29.…”

Graphene-Based Nanomaterials in Bioimaging

“…For instance, GO/iron oxide composites can be synthesized by the following methods: Fe 3+ /Fe 2+ ions in the proper molar ratio (2:1) were mixed with GO, and then were precipitated by alkaline solutions, such as ammonia solution (NH 3 •H 2 O), and sodium hydroxide (NaOH) (33,34). Besides the coprecipitation strategy of Fe 3+ and Fe 2+ ions under alkaline condition, hydrothermal reaction was also employed to prepare GO/iron oxide composites by using iron chloride hexahydrate as the iron source (30,35). The as-prepared GO/iron oxide composites can be used as MR contrast agents for MRI.…”

Hybrid Nanocarbon Materials for Magnetic Resonance and Fluorescent Imaging: A Mini Review

“…Herein, we attach immense importance to multimodal imaging from the combination of MRI with FOI. The integration of magnetic and fluorescent components into the carbon-based hybrid NPs can provide not only the MRI contrast, but also the confocal, two-photon and NIR fluorescence imaging contrast [23][24][25][26].…”