Multimodal imaging characteristics of quiescent type 1 neovascularization in an eye with angioid streaks

Abstract

PurposeTo present the multimodal imaging characteristics including optical coherence tomography angiography (OCTA) as well as indocyanine green angiography (ICGA) of quiescent type 1 neovascularization (NV) in an asymptomatic eye with angioid streaks (AS).ObservationsA 67-year-old male patient was admitted to our clinic for routine eye examination. The presence of a quiescent type 1 NV was detected on both ICGA and OCTA in juxtafoveal localization under the retinal pigment epitheliumin the right eye. At the end of the one year of follow-up, the patient was asymptomatic and the type 1 NV was still quiescent.Conclusions and ImportanceIn comparison to ICGA, OCTA seems to be an easily repeatable non-invasive imaging tool which enables us early detection and monitoring of type 1 NV lesions even in asymptomatic patients with AS.

Optical Coherence Tomography Characteristics of Quiescent Type 1 Neovascularization in Eyes with Nonexudative Age-related Macular Degeneration

“…Various clinical studies using SD-OCT, ICGA, and optical coherence tomography angiography (OCTA) have shown that quiescent NV lesions not yet causing exudative findings may be present in eyes with nonexudative AMD, polipoidal choroidal vasculopathy, and angioid streaks. 2,3,4,5,6,7,8,9…”

“…In addition, they observed horizontal enlargement of the NV lesions during follow-up. Menteş et al 7 defined the multimodal imaging characteristics of quiescent type 1 NV lesions before the appearance of exudative findings in an eye with angioid streaks using SD-OCT, FA, ICGA, and OCTA.…”

“…3 Using multimodal imaging methods, it was shown that eyes with nonexudative AMD may have quiescent type 1 NV that does not yet show signs of activation (i.e., exudative symptoms). 2,3,4,5,6,7,8 Knowing the characteristic SD-OCT features of these quiescent, subclinical type 1 NV lesions will facilitate early diagnosis and close follow-up of the lesions, enabling early treatment before severe losses in visual acuity.…”

Multimodal Imaging Characteristics of Quiescent Type 1 Neovascularization in Best Vitelliform Macular Dystrophy

“…Several studies published in recent years have reported that quiescent NV lesions can be found in many retinal diseases, especially age-related macular degeneration, and that they may remain asymptomatic for years. 8 , 9 Histologically, NVs are divided into three types: type 1 NV, which is located under the retinal pigment epithelium (RPE) (angiographically occult); type 2, which originates from the choroid and passes through Bruch’s membrane and RPE to extend into the subretinal space (angiographically classic); and type 3, which develops within the neurosensory retina (retinal angiomatous proliferation). 10 In our case, the NV lesion was seen at the choriocapillaris level on OCTA and was therefore classified as type 1.…”

“…In addition, it has been reported in various studies that OCTA may be useful in various retinal diseases for the early detection of inactive and quiescent NV structures that do not yet show exudative symptoms. 8 …”