Multimodal Imaging-Based Phenotyping of a Singaporean Hospital-Based Cohort of High Myopia Patients

Tey, Kai Yuan; Hoang, Quan V.; Loh, Isabella; Dan, Yee Shan; Wong, Qiu Ying; Yu, Daryle Jason Go; Yandri, Vivi R; Ang, Marcus; Cheung, Gemmy; Lee, Shu Yen; Wong, Tien Yin; Chong, Rachel S.; Wong, Chee Wai

doi:10.3389/fmed.2021.670229

Cited by 3 publications

(2 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 43 , 44 In high myopes with AL exceeding 27.5 mm, the prevalence can even reach 98%. 45 The presence of β-PPA is associated with age, myopic refractive error, long AL, and visual acuity, 45 , 46 and the area of β-PPA is positively associated with AL. 47 Yan et al 32 reported that fundus tessellations were associated with β-PPA.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Characteristics of Myopia in Adult Rhesus Macaques in Southwest China

Lin

Zhao

2023

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Purpose To investigate the prevalence of myopia in a large cohort of adult rhesus macaques at Yunnan Province in southwest China and describe the characteristics of myopic rhesus macaque eyes. Methods A total of 219 rhesus macaques 14.07 ± 2.72 years old (range, 8–21) were randomly recruited for this study. We performed fundus photography and measurements of cycloplegic refractive error (RE) and axial length (AL) on macaques. Results A total of 429 eyes of 219 macaques were examined. The median RE was −1.25 diopters (D), and the median AL was 18.69 mm. The prevalence of myopia was 62.47%, and one-third of the myopic eyes were highly myopic. The presence of fundus tessellations was higher in myopic eyes than non-myopic eyes (42.54% vs. 6.21%). The cutoff value for the presence of tessellations was −3.52 D for RE and 19.38 mm for AL. In myopic eyes, there were significant differences between grade 1 and grade 3 fundus tessellations on RE (−5.57 ± 2.97 D vs. −8.13 ± 3.51 D) and AL (19.66 ± 0.55 mm vs. 20.60 ± 1.06 mm). Beta-peripapillary atrophy (β-PPA) was found in 48.10% of myopic eyes and 6.83% of non-myopic eyes. The presence of β-PPA is associated with the presence of fundus tessellations, AL, and RE. The presence of β-PPA was higher in grade 3 than grade 1 fundus tessellations (94.4% vs. 76%). Conclusions More than half of adult rhesus macaques in southwest China are myopic, and one-third of the myopic ones are highly myopic. Similar to humans, tessellated fundi and β-PPA are the characteristic signs of myopic rhesus macaques. Adult rhesus macaques are optimal animal models for research on the pathogenesis of myopia. Translational Relevance This study not only provides a reference for the refractive state and AL in myopic rhesus macaques but also indicates that adult rhesus macaques with spontaneous myopia are optimal animal models for research on the pathogenesis of myopia.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence and Characteristics of Myopia in Adult Rhesus Macaques in Southwest China

Lin

Zhao

2023

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

show abstract

“…However, Previous research showed that adults with high myopia continue to have an increase in AL and the increased risk factors seem unchangeable [20] . Increased age, increased diopters, and AL elongation are important risk factors in fundus disease progression in patients with high myopia [21][22] . With lengthening of the AL and expansion of the eyeball, the sclera is continuously extended and thinned, leading to a series of changes in the choroid and retina and resulting in high myopia [23] .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2023

Int J Ophthalmol

View full text Add to dashboard Cite

AIM: To explore changes in the optic disc and peripapillary atrophy (PPA) in school-age children with ametropia using color fundus photography combined with artificial intelligence (AI) technology.• METHODS: Based on the retrospective case-controlled study, 226 eyes of 113 children aged aged 6-12y were enrolled from October 2021 to May 2022. According to the results of spherical equivalent (SE), the children were divided into four groups: low myopia group (66 eyes), moderate myopia group (60 eyes), high myopia group (50 eyes) and emmetropia control group (50 eyes). All subjects underwent un-aided visual acuity, dilated pupil optometry, best-corrected visual acuity (BCVA), intraocular pressure, ocular axis measurement and color fundus photography.• RESULTS: The width of PPA, horizontal diameter ratio of PPA to the optic disc and area ratio of PPA to the optic disc were significantly different among the four groups (P<0.05). The width of the nasal and temporal neuroretinal rim, the roundness of the optic disc, the height of PPA, the vertical diameter ratio of PPA to the optic disc, and the average density of PPA in the high myopia group were significantly different compared with the other three groups (P<0.05). There were strong negative correlations between SE and area ratio of PPA to the optic disc (r=-0.812, P<0.001) and strong positive correlation between axial length (AL) and area ratio of PPA to the optic disc (r=0.736, P<0.001).• CONCLUSION: In school-age children with high myopia, the nasal and temporal neuroretinal rims are narrowed and even lost, which have high sensitivity. The area ratio of the PPA to the optic disc could be used as an early predictor of myopia progression, which is of great significance for the development prevention and management of myopia.

show abstract

Pathologic myopia in highly myopic patients with high axial anisomyopia

Dan²,

Chua³

et al. 2023

Br J Ophthalmol

View full text Add to dashboard Cite

PurposeTo determine prevalence of anisomyopia (axial length (AL) difference ≥2.5 mm) among high myopes ((HMs), defined by spherical equivalent of ≤6.0 diopters or AL ≥ 26.5 mm). To characterise the shorter anisomyopic eye (SAE) and evaluate if pathologic myopia (PM) in the longer anisomyopic eye (LAE) was associated with increased risk of PM in the SAE.Methods1168 HMs were recruited from Singapore National Eye Centre clinic for this cross-sectional study. Biometry, fundus photography and swept-source optical coherence tomography were performed. Patients with high axial anisomyopia were identified. Structural characteristics and presence of PM were described. Stepwise multivariate regression explored associations between PM in the LAE and pathology in the SAE, controlling for confounding variables.ResultsPrevalence of anisomyopia was 15.8% (184 of 1168 patients). Anisomyopic patients (age 65.8±13.5 years) had mean AL of 30.6±2.0 mm and 26.2±2.3 mm in the LAE and SAE, respectively. 52.7% of SAEs had AL < 26.5 mm. Prevalence of myopic macular degeneration, macula-involving posterior staphyloma (PS), myopic traction maculopathy (MTM) and myopic choroidal neovascularisation (mCNV) in the SAE was 52.2%, 36.5%, 13.0% and 8.2%, respectively. Macular hole in the LAE was associated with increased risk of MTM in the SAE (OR=4.88, p=0.01). mCNV in the LAE was associated with mCNV in the SAE (OR=3.57, p=0.02). PS in the LAE was associated with PS in the SAE (OR=4.03, p<0.001).ConclusionsEven when controlled for AL, PM complications in the LAE predict similar PM complications in the SAE. Patients with high axial anisometropia with PM in the LAE should be monitored carefully for complications in the SAE.

show abstract

Multimodal Imaging-Based Phenotyping of a Singaporean Hospital-Based Cohort of High Myopia Patients

Cited by 3 publications

References 62 publications

Prevalence and Characteristics of Myopia in Adult Rhesus Macaques in Southwest China

Prevalence and Characteristics of Myopia in Adult Rhesus Macaques in Southwest China

Untitled

Pathologic myopia in highly myopic patients with high axial anisomyopia

Contact Info

Product

Resources

About