Multimodal Imaging Analysis Reveals Frontal-Associated Networks in Relation to Individual Resilience Strength

Abstract

Psychological resilience is regarded as a critical protective factor for preventing the development of mental illness from experienced adverse events. Personal strength is one key element of resilience that reflects an individual’s reactions to negative life events and is crucial for successful adaptation. Previous studies have linked unimodal imaging measures with resilience. However, applying multimodal imaging measures could provide comprehensive organization information at the system level to examine whether an individual’s resilience strength is reflected in the brain’s structural and functional network. In this study, MRI was used to acquire multimodal imaging properties and subscales of personal strength in terms of resilience from 109 participants (48 females and 61 males). We employed a method of fusion independent component analysis to link the association between multimodal imaging components and personal strength of psychological resilience. The results reveal that a fusion component involving multimodal frontal networks in connecting with the parietal, occipital, and temporal regions is associated with the resilience score for personal strength. A multiple regression model further explains the predictive role of frontal-associated regions that cover a visual-related network regulating cognition and emotion to discern the perceived adverse experience. Overall, this study suggests that frontal-associated regions are related to individual resilience strength.

Factors associated with changes in psychological resilience of older adults with mild cognitive impairment during the COVID-19 pandemic

“…In other words, psychological resilience might have improved in the present study because respondents who experienced good sleep quality were able to maintain high functioning in their emotion control spheres. In neuroimaging, psychological resilience is related to the frontal-associated regions, including the mPFC, amygdala, and anterior cingulate cortex ( Hsieh et al, 2021 ). Among these frontal-associated regions, the functional connectivity between the mPFC and the amygdala is involved in sleep and emotion.…”

“…This acts as a protective factor preventing the worsening of depressive symptoms ( Chang et al, 2023a ). Some studies have reported that several brain regions are involved in psychological resilience, including the medial prefrontal cortex (mPFC), which functions as a mechanism for psychological resilience ( Bremner, 2007 ; Menon and Uddin, 2010 ; Hsieh et al, 2021 ; Chang et al, 2023b ). However, the state of psychological resilience in older adults with MCI has not been described; understanding this state can help develop supportive mental health measures.…”

The interventions for resilience of breast cancer patients: a systematic review and meta-analysis

“…Although the existing interventions seem to be effective for promoting resilience of breast cancer patients, the current evidences are still in the preliminary research stage and the quality of them were not high. Recently, more and more studies have shown that in addition to social and psychological factors, biological mechanisms such as the amygdala, hippocampus, ventral striatum and frontal-associated regions of the brain are related to resilience strength [11,59]. An improved understanding of the biological mechanisms-based intervention could reveal novel therapeutic targets and help clarifying which psychosocial interventions can improve the psychological elasticity of breast cancer patients [60].…”

The effect of age and resilience on the dose–response function between the number of adversity factors and subjective well-being

“…For the preprocessing of the functional images, we employed the CONN toolbox 18a 3 and SPM 12 4 within Matlab (The MathWorks, Inc., Natick, MA, United States). Our preprocessing protocol was adapted from Geerligs and Tsvetanov's ( 2017) study (see also Hsieh et al, 2021).…”