Multimodal α-Glucosidase and α-Amylase Inhibition and Antioxidant Effect of the Aqueous and Methanol Extracts from the Trunk Bark of Ceiba pentandra

Nguelefack, Télesphore Benoît; Fofié, Christian Kuete; Nguelefack‐Mbuyo, Elvine Pami; Wuyt, Adeline Kaptué

doi:10.1155/2020/3063674

Cited by 22 publications

(24 citation statements)

References 48 publications

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“…The inhibitory activity of α -glucosidase by AEPAS was determined via a procedure provided by Nguelefack et al 61 . 1 mg of α-glucosidase was dissolved in a phosphate buffer (100 ml) at a pH of about 6.8 and containing 200 mg of bovine serum albumin (BSA).…”

Section: Methodsmentioning

confidence: 99%

Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Ojo

Amanze

Oni

et al. 2022

Sci Rep

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The treatment of diabetes involves the use of herbal plants, attracting interest in their cost-effectiveness and efficacy. An aqueous extract of Persea americana seeds (AEPAS) was explored in this study as a possible therapeutic agent in rats with diabetes mellitus. The induction of diabetes in the rats was achieved by injecting 65 mg/kg body weight (BWt) of alloxan along with 5% glucose. This study was conducted using thirty-six (36) male Wistar rats. The animals were divided into 6 equal groups, (n = 6) and treated for 14 days. In vitro assays for total flavonoid, phenols, FRAP, DPPH, NO, α-amylase, and α-glucosidase, were performed. Biochemical indices fasting blood sugar (FBS), BWt, serum insulin, liver hexokinase, G6P, FBP, liver glycogen, IL-6, TNF-α, and NF-ĸB in the serum, were investigated as well as the mRNA expressions of PCNA, Bcl2, PI3K/Akt in the liver and pancreas. The in vitro analyses showed the potency of AEPAS against free radicals and its enzyme inhibitory potential as compared with the positive controls. AEPAS showed a marked decrease in alloxan-induced increases in FBG, TG, LDL-c, G6P, F-1, 6-BP, MDA, IL-6, TNF-α, and NF-ĸB and increased alloxan-induced decreases in liver glycogen, hexokinase, and HDL-c. The diabetic control group exhibited pancreatic dysfunction as evidenced by a reduction in serum insulin, HOMA-β, expressions of PI3K/AKT, Bcl-2, and PCNA combined with an elevation in HOMA-IR. The HPLC revealed luteolin and myricetin to be the phytochemicals that were present in the highest concentration in AEPAS. The outcome of this research showed that the administration of AEPAS can promote the activation of the PI3K/AkT pathway and the inhibition of β-cell death, which may be the primary mechanism by which AEPAS promotes insulin sensitivity and regulates glycolipid metabolism.

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Section: Methodsmentioning

confidence: 99%

Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Ojo

Amanze

Oni

et al. 2022

Sci Rep

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“…pentandra scavenged the DPPH radicals with an IC 50 value of 0.0716 mg/mL [ 184 ]. The aqueous and methanol stem bark extracts of C. pentandra inhibited superoxide (O 2 • − ) (IC 50 values of 51.81 and 34.26 μg/mL), hydrogen peroxide (44.84 and 1.78 μg/mL), and protein oxidation induced by H 2 O 2 (120.60 and 140.40 μg/mL) [ 168 ].…”

Section: Pharmacological Potential Of Bombacoideaementioning

confidence: 99%

“…The ethanolic bark extract of C. pentandra at 200 mg/kg dose exhibited antihyperglycemic activity in STZ-induced diabetic rats by decreasing the levels of blood glucose, total cholesterol, and triglycerides, preventing degeneration of liver and pancreas, and increasing serum insulin and liver glycogen content [ 180 ]. The aqueous stem bark extracts of C. pentandra inhibited alpha-amylase and glucosidase with IC 50 values of 6.15 and 76.61 μg/mL, respectively, whereas the methanol extract inhibited alpha-amylase and glucosidase with IC 50 values of 54.52 and 86.49 μg/mL, respectively [ 168 ].…”

Section: Pharmacological Potential Of Bombacoideaementioning

confidence: 99%

Systematics, Phytochemistry, Biological Activities and Health Promoting Effects of the Plants from the Subfamily Bombacoideae (Family Malvaceae)

Das

Shin

Ningthoujam³

et al. 2021

Plants

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Plants belonging to the subfamily Bombacoideae (family Malvaceae) consist of about 304 species, many of them having high economical and medicinal properties. In the past, this plant group was put under Bombacaceae; however, modern molecular and phytochemical findings supported the group as a subfamily of Malvaceae. A detailed search on the number of publications related to the Bombacoideae subfamily was carried out in databases like PubMed and Science Direct using various keywords. Most of the plants in the group are perennial tall trees usually with swollen tree trunks, brightly colored flowers, and large branches. Various plant parts ranging from leaves to seeds to stems of several species are also used as food and fibers in many countries. Members of Bombacoides are used as ornamentals and economic utilities, various plants are used in traditional medication systems for their anti-inflammatory, astringent, stimulant, antipyretic, microbial, analgesic, and diuretic effects. Several phytochemicals, both polar and non-polar compounds, have been detected in this plant group supporting evidence of their medicinal and nutritional uses. The present review provides comprehensive taxonomic, ethno-pharmacological, economic, food and phytochemical properties of the subfamily Bombacoideae.

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“…The International Diabetes Federation estimated that 451 million people were living with diabetes in 2017, and this number could rise to 693 million by 2045, especially in low- and middle-income countries, where the greatest increase is expected to occur [ 1 ]. The postprandial hyperglycemia associated with T2DM causes oxidative stress, which impairs endothelial cell function and eventually causes microvascular and macrovascular complications [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effects of a Bean-Based and a White Rice-Based Breakfast Diet on Postprandial Glucose and Insulin Levels in Chinese Patients with Type 2 Diabetes

Xiong

Nie

et al. 2021

Med Sci Monit

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Background This study compared the effects of a bean-based and a white rice-based breakfast diet on postprandial glucose and insulin levels in Chinese patients with type 2 diabetes mellitus (T2DM). Material/Methods We recruited 63 patients with T2DM. The patients participated in the randomized 2×2 crossover trial. The bean-based diet group and white rice control group were matched for 50 g of available carbohydrate at breakfast. The patients followed the diets for 3 days. Vein blood samples were collected at 0, 30, 60, 120, and 180 min after eating. Data were analyzed using a repeated-measures analysis of variance. The results are expressed as the mean±standard error of mean (SEM) or as the median with interquartile range values. Results Compared with the white rice control, postprandial glucose was significantly lower with the bean-based diet treatments at 60 min ( P =0.004), 120 min ( P =0.000), and 180 min ( P =0.000). The insulin levels of the bean-based diet group were significantly higher at 60 min ( P =0.013). The C-peptide levels of the bean-based diet group were significantly higher at 30 min ( P =0.042) and 60 min ( P =0.005) postprandial. The glucose area under the curve (AUC) showed a similar trend ( P =0.000). There were no statistically significant differences in the AUC of insulin and C-peptide, except C-peptide AUC at 0 to 60 min ( P =0.027). Conclusions Compared with a white rice-based breakfast, a bean-based diet significantly reduced postprandial glucose levels and promoted insulin secretion. These results support a dietary approach to reduce postprandial hyperglycemia.

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Multimodal α-Glucosidase and α-Amylase Inhibition and Antioxidant Effect of the Aqueous and Methanol Extracts from the Trunk Bark of Ceiba pentandra

Cited by 22 publications

References 48 publications

Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Systematics, Phytochemistry, Biological Activities and Health Promoting Effects of the Plants from the Subfamily Bombacoideae (Family Malvaceae)

Comparison of the Effects of a Bean-Based and a White Rice-Based Breakfast Diet on Postprandial Glucose and Insulin Levels in Chinese Patients with Type 2 Diabetes

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